Quantitative Examination of the Active Targeting Effect: The Key Factor for Maximal Tumor Accumulation and Retention of Short-Circulated Biopolymeric Nanocarriers

Jianquan Wang, Gee Young Lee, Qian Lu, Xianghong Peng, Jiangxiao Wu, Siyuan Wu, Brad A. Kairdolf, Shuming Nie, Yiqing Wang, Lucas A. Lane

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Targeted and nontargeted biopolymeric nanoparticles with identical hydrodynamic sizes and surface charges were quantitatively examined in terms of the pharmacokinetic and biodistribution differences in detail. In adding cancer cell targeting folate molecules to the surface of the heparin nanocarriers, the amount of drug delivered to the tumor is doubled, and tumor growth inhibition is significantly enhanced. The folate-targeted heparin particles offered similar therapeutic potentials compared to their synthetic long-circulating analogues, thus presenting a viable alternative for drug-delivery vehicle construction using biological polymers, which are easier for the body to eliminate.

Original languageEnglish
Pages (from-to)1351-1355
Number of pages5
JournalBioconjugate Chemistry
Volume28
Issue number5
DOIs
Publication statusPublished - May 17 2017
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

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