Quantitative determination of hydrazines derived from isoniazid in patients. I

Atsuko Noda, Tsuyoshi Goromaru, Kuang yang Hsu, Sadao Iguchi

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Hydrazine formation took place in man after the oral administration of isoniazid. The successive excretion of free hydrazine, one of the well-known mutagens, was observed in the urine of the patients on INH-treatment. The intact INH and the other metabolites, acetyl-INH, acetyl-hydrazine and diacetylhydrazine, were also analyzed by gas chromatography-mass spectrometry.

Original languageEnglish
Pages (from-to)132-141
Number of pages10
JournalJournal of Pharmacobio-Dynamics
Volume1
Issue number2
DOIs
Publication statusPublished - 1978
Externally publishedYes

Keywords

  • GC and GC-MS
  • patient on INH-treatment
  • quantitative analysis
  • successive excretion of free hydrazine
  • the metabolites in urine

ASJC Scopus subject areas

  • Pharmacology

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