Quantitative determination of hydrazines derived from isoniazid in patients. I

Atsuko Noda, Tsuyoshi Goromaru, Kuang yang Hsu, Sadao Iguchi

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Hydrazine formation took place in man after the oral administration of isoniazid. The successive excretion of free hydrazine, one of the well-known mutagens, was observed in the urine of the patients on INH-treatment. The intact INH and the other metabolites, acetyl-INH, acetyl-hydrazine and diacetylhydrazine, were also analyzed by gas chromatography-mass spectrometry.

Original languageEnglish
Pages (from-to)132-141
Number of pages10
JournalJournal of Pharmacobio-Dynamics
Volume1
Issue number2
DOIs
Publication statusPublished - 1978
Externally publishedYes

Fingerprint

hydrazine
Hydrazines
Isoniazid
Mutagens
Gas Chromatography-Mass Spectrometry
Oral Administration
Urine

Keywords

  • GC and GC-MS
  • patient on INH-treatment
  • quantitative analysis
  • successive excretion of free hydrazine
  • the metabolites in urine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Quantitative determination of hydrazines derived from isoniazid in patients. I. / Noda, Atsuko; Goromaru, Tsuyoshi; Hsu, Kuang yang; Iguchi, Sadao.

In: Journal of Pharmacobio-Dynamics, Vol. 1, No. 2, 1978, p. 132-141.

Research output: Contribution to journalArticle

Noda, Atsuko ; Goromaru, Tsuyoshi ; Hsu, Kuang yang ; Iguchi, Sadao. / Quantitative determination of hydrazines derived from isoniazid in patients. I. In: Journal of Pharmacobio-Dynamics. 1978 ; Vol. 1, No. 2. pp. 132-141.
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