Quantitative analysis of CDKN2, p53 and retinoblastoma mRNA in human gastric carcinoma

Yi Jen Chen, Li Sun Shih, Yi Ming A. Chen

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The mRNA level of CDKN2 (p16), retinoblastoma (Rb) and p53 in cancerous and non-cancerous tissue samples were compared using a semi-quantitative reverse-transcription-polymerase chain reaction method. The mean CDKN2 mRNA level of 10 gastric cancer specimens was significantly higher than that of their non-cancerous tissue samples (p=0.039). In contrast, the mRNA levels of Rb and p53 in gastric cancer tissues were both significantly lower than those in their noncancerous tissue samples. Furthermore, both mRNA ratios of Rb/CDKN2 and p53/CDKN2 were significantly decreased in gastric cancer tissues. Therefore, suppression of both Rb and p53 and overexpression of CDKN2 may be associated with the tumorigenesis of gastric cancer.

Original languageEnglish
Pages (from-to)249-254
Number of pages6
JournalInternational Journal of Oncology
Volume13
Issue number2
Publication statusPublished - Aug 1 1998
Externally publishedYes

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Keywords

  • Gastric carcinomas
  • p16
  • p53
  • Retinoblastoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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