Quantification of prenatal exposure and maternal-fetal transfer of nonylphenol

Mei Lien Chen, Chi Chang Chang, Yi Ju Shen, Jeng Hsiu Hung, Bey Rong Guo, Hsin Yi Chuang, I. Fang Mao

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Nonylphenol (NP) is an environmental hormone commonly found in daily foodstuffs. This study examined maternal and umbilical-cord blood samples to explore prenatal exposure levels to nonylphenol and placental protection against NP exposure. One hundred and seventy-four mixed cord blood samples were collected. Among them, 42 pairs of expectant mothers and their prenatal fetus were matched to compare nonylphenol levels between mothers and fetuses. An additional 30 mother-infant dyads were chosen to give maternal, umbilical arterial and venous blood samples. Plasma samples were enzymatically deconjugated and then cleaned up with solid-phase extraction. After extraction, samples were analyzed with reversed-phase high-performance liquid chromatography coupled with fluorescence detection. Analytical results identified prenatal exposure to NPs and relatively high prenatal exposure levels in metropolitan areas. The concentrations ranged from undetectable (below 1.82 ng/g plasma) to 211 ng/g plasma. Concentrations of NP in mother-infant dyads showed the NP concentrations in maternal plasma were not definitely higher than that in fetal plasma. Still, 63.6% of NP detectable mother-infant dyads showed a higher concentration in umbilical venous plasma than those in umbilical arterial plasma. Through the repeated exposure from expectant mothers' dietary intake, fetuses could encounter high NP exposure level due to transplacental absorption, partitioning between the maternal and fetal compartments, as well as poor detoxification mechanisms of the developing organism. Some mechanisms may contribute to the reduction of NP levels in fetal blood circulation but those remain unclear.

Original languageEnglish
JournalChemosphere
Volume73
Issue number1 SUPPL.
DOIs
Publication statusPublished - Aug 2008

Fingerprint

Maternal Exposure
Mothers
Plasmas
plasma
blood
Umbilicus
Blood
Fetal Blood
Fetus
Detoxification
Hormones
Hemodynamics
High performance liquid chromatography
detoxification
nonylphenol
exposure
metropolitan area
hormone
liquid chromatography
Blood Circulation

Keywords

  • Environmental hormone
  • Nonylphenol
  • Placental transfer
  • Umbilical-cord plasma

ASJC Scopus subject areas

  • Environmental Chemistry
  • Environmental Science(all)

Cite this

Chen, M. L., Chang, C. C., Shen, Y. J., Hung, J. H., Guo, B. R., Chuang, H. Y., & Mao, I. F. (2008). Quantification of prenatal exposure and maternal-fetal transfer of nonylphenol. Chemosphere, 73(1 SUPPL.). https://doi.org/10.1016/j.chemosphere.2007.04.091

Quantification of prenatal exposure and maternal-fetal transfer of nonylphenol. / Chen, Mei Lien; Chang, Chi Chang; Shen, Yi Ju; Hung, Jeng Hsiu; Guo, Bey Rong; Chuang, Hsin Yi; Mao, I. Fang.

In: Chemosphere, Vol. 73, No. 1 SUPPL., 08.2008.

Research output: Contribution to journalArticle

Chen, ML, Chang, CC, Shen, YJ, Hung, JH, Guo, BR, Chuang, HY & Mao, IF 2008, 'Quantification of prenatal exposure and maternal-fetal transfer of nonylphenol', Chemosphere, vol. 73, no. 1 SUPPL.. https://doi.org/10.1016/j.chemosphere.2007.04.091
Chen, Mei Lien ; Chang, Chi Chang ; Shen, Yi Ju ; Hung, Jeng Hsiu ; Guo, Bey Rong ; Chuang, Hsin Yi ; Mao, I. Fang. / Quantification of prenatal exposure and maternal-fetal transfer of nonylphenol. In: Chemosphere. 2008 ; Vol. 73, No. 1 SUPPL.
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