QSAR analysis of the lipid peroxidation inhibitory activity with structure and energetics of 36 flavonoids derivatives

Hsien Ren Liao, Yeong Sheng Chang, Yu Chun Lin, Ling Ling Yang, Yu Ma Chou, Bo Cheng Wang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The biological activity relationship of 36 flavonoid compounds was investigated using theoretical methods including quantitative structure activity relationships (QSAR) and quantum chemistry calculation. The results suggested that the 5 and/or 8 positions of the substituents of the hydroxyl group in the A ring and the 3′ and 4′ positions of substituents of the hydroxyl group in the B ring play an important role in flavonoid biological activity. This is probably due to the formation of an intra-molecular hydrogen bond. In addition, the electronic energy, electrostatic energy and bond energy may have an effect on the biological activity of flavonoids. Also, our analysis has shown that the presence of the 1,4 and 1,2-hydroquinone in the A ring and/or the B ring of flavonoids and the contribution of electronic energy, electrostatic energy and bond energy required consideration in the generation of the QSAR model and that the potential compounds will be predicted out of 36 flavonoids.

Original languageEnglish
Pages (from-to)1251-1261
Number of pages11
JournalJournal of the Chinese Chemical Society
Volume53
Issue number6
Publication statusPublished - 2006

Fingerprint

Flavonoids
Derivatives
Lipids
Bioactivity
Hydroxyl Radical
Electrostatics
Quantum chemistry
Hydrogen bonds

Keywords

  • Antioxidant activity
  • Flavonoids
  • Lipid peroxidation
  • PM3
  • QSAR

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Liao, H. R., Chang, Y. S., Lin, Y. C., Yang, L. L., Chou, Y. M., & Wang, B. C. (2006). QSAR analysis of the lipid peroxidation inhibitory activity with structure and energetics of 36 flavonoids derivatives. Journal of the Chinese Chemical Society, 53(6), 1251-1261.

QSAR analysis of the lipid peroxidation inhibitory activity with structure and energetics of 36 flavonoids derivatives. / Liao, Hsien Ren; Chang, Yeong Sheng; Lin, Yu Chun; Yang, Ling Ling; Chou, Yu Ma; Wang, Bo Cheng.

In: Journal of the Chinese Chemical Society, Vol. 53, No. 6, 2006, p. 1251-1261.

Research output: Contribution to journalArticle

Liao, Hsien Ren ; Chang, Yeong Sheng ; Lin, Yu Chun ; Yang, Ling Ling ; Chou, Yu Ma ; Wang, Bo Cheng. / QSAR analysis of the lipid peroxidation inhibitory activity with structure and energetics of 36 flavonoids derivatives. In: Journal of the Chinese Chemical Society. 2006 ; Vol. 53, No. 6. pp. 1251-1261.
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