Pulsed high-dose dexamethasone therapy in children with chronic idiopathic thrombocytopenic purpura

Jiann Shiuh Chen, Jing Ming Wu, Yung Jung Chen, Tsu Fuh Yeh

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Purpose: The effectiveness of pulsed high-dose oral dexamethasone therapy in children with refractory chronic idiopathic thrombocytopenic purpura (ITP) is evaluated. Patients and Methods: Seven children (5 to 16 years old) who were refractory to 2 to 5 conventional standard therapies were included in the study. Dexamethasone was administered orally at a dosage of 40 mg/m2 per day (maximum 40 mg/day) for 4 consecutive days as a cycle. The cycle was repeated once a month for 6 months. Results: One month after the first cycle, partial responses of platelet counts (≤50 x 109/L and <150 x 109/L) were observed in three patients (43%). At the end of the sixth cycle, two patients (29%) had complete responses (>150 x 109/L) and one had a partial response. However, only one patient (14%) remained partially responsive I year after completion of therapy. Conclusions: In contrast to what was observed in adults, this preliminary study suggests that pulsed high-dose oral dexamethasone therapy was not uniformly effective in children with chronic ITP.

Original languageEnglish
Pages (from-to)526-529
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Volume19
Issue number6
DOIs
Publication statusPublished - Nov 1 1997
Externally publishedYes

Fingerprint

Idiopathic Thrombocytopenic Purpura
Dexamethasone
Therapeutics
Platelet Count

Keywords

  • Chronic idiopathic thrombocytopenia purpura
  • Dexamethasone
  • Pulsed therapy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

Cite this

Pulsed high-dose dexamethasone therapy in children with chronic idiopathic thrombocytopenic purpura. / Chen, Jiann Shiuh; Wu, Jing Ming; Chen, Yung Jung; Yeh, Tsu Fuh.

In: Journal of Pediatric Hematology/Oncology, Vol. 19, No. 6, 01.11.1997, p. 526-529.

Research output: Contribution to journalArticle

@article{4cbb137571c548f1b8d8e16d55dfcd0c,
title = "Pulsed high-dose dexamethasone therapy in children with chronic idiopathic thrombocytopenic purpura",
abstract = "Purpose: The effectiveness of pulsed high-dose oral dexamethasone therapy in children with refractory chronic idiopathic thrombocytopenic purpura (ITP) is evaluated. Patients and Methods: Seven children (5 to 16 years old) who were refractory to 2 to 5 conventional standard therapies were included in the study. Dexamethasone was administered orally at a dosage of 40 mg/m2 per day (maximum 40 mg/day) for 4 consecutive days as a cycle. The cycle was repeated once a month for 6 months. Results: One month after the first cycle, partial responses of platelet counts (≤50 x 109/L and <150 x 109/L) were observed in three patients (43{\%}). At the end of the sixth cycle, two patients (29{\%}) had complete responses (>150 x 109/L) and one had a partial response. However, only one patient (14{\%}) remained partially responsive I year after completion of therapy. Conclusions: In contrast to what was observed in adults, this preliminary study suggests that pulsed high-dose oral dexamethasone therapy was not uniformly effective in children with chronic ITP.",
keywords = "Chronic idiopathic thrombocytopenia purpura, Dexamethasone, Pulsed therapy",
author = "Chen, {Jiann Shiuh} and Wu, {Jing Ming} and Chen, {Yung Jung} and Yeh, {Tsu Fuh}",
year = "1997",
month = "11",
day = "1",
doi = "10.1097/00043426-199711000-00007",
language = "English",
volume = "19",
pages = "526--529",
journal = "Journal of Pediatric Hematology/Oncology",
issn = "1077-4114",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Pulsed high-dose dexamethasone therapy in children with chronic idiopathic thrombocytopenic purpura

AU - Chen, Jiann Shiuh

AU - Wu, Jing Ming

AU - Chen, Yung Jung

AU - Yeh, Tsu Fuh

PY - 1997/11/1

Y1 - 1997/11/1

N2 - Purpose: The effectiveness of pulsed high-dose oral dexamethasone therapy in children with refractory chronic idiopathic thrombocytopenic purpura (ITP) is evaluated. Patients and Methods: Seven children (5 to 16 years old) who were refractory to 2 to 5 conventional standard therapies were included in the study. Dexamethasone was administered orally at a dosage of 40 mg/m2 per day (maximum 40 mg/day) for 4 consecutive days as a cycle. The cycle was repeated once a month for 6 months. Results: One month after the first cycle, partial responses of platelet counts (≤50 x 109/L and <150 x 109/L) were observed in three patients (43%). At the end of the sixth cycle, two patients (29%) had complete responses (>150 x 109/L) and one had a partial response. However, only one patient (14%) remained partially responsive I year after completion of therapy. Conclusions: In contrast to what was observed in adults, this preliminary study suggests that pulsed high-dose oral dexamethasone therapy was not uniformly effective in children with chronic ITP.

AB - Purpose: The effectiveness of pulsed high-dose oral dexamethasone therapy in children with refractory chronic idiopathic thrombocytopenic purpura (ITP) is evaluated. Patients and Methods: Seven children (5 to 16 years old) who were refractory to 2 to 5 conventional standard therapies were included in the study. Dexamethasone was administered orally at a dosage of 40 mg/m2 per day (maximum 40 mg/day) for 4 consecutive days as a cycle. The cycle was repeated once a month for 6 months. Results: One month after the first cycle, partial responses of platelet counts (≤50 x 109/L and <150 x 109/L) were observed in three patients (43%). At the end of the sixth cycle, two patients (29%) had complete responses (>150 x 109/L) and one had a partial response. However, only one patient (14%) remained partially responsive I year after completion of therapy. Conclusions: In contrast to what was observed in adults, this preliminary study suggests that pulsed high-dose oral dexamethasone therapy was not uniformly effective in children with chronic ITP.

KW - Chronic idiopathic thrombocytopenia purpura

KW - Dexamethasone

KW - Pulsed therapy

UR - http://www.scopus.com/inward/record.url?scp=0031425150&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031425150&partnerID=8YFLogxK

U2 - 10.1097/00043426-199711000-00007

DO - 10.1097/00043426-199711000-00007

M3 - Article

VL - 19

SP - 526

EP - 529

JO - Journal of Pediatric Hematology/Oncology

JF - Journal of Pediatric Hematology/Oncology

SN - 1077-4114

IS - 6

ER -