Pulsatile ocular blood flow change after treatment with systemic steroid in patients with Graves' ophthalmopathy

C. C. Tsai, H. C. Kau, H. H. Tsai, S. C. Kao, Wen-Ming Hsu

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose: Our previous study has demonstrated an impairment of pulsatile ocular blood flow (POBF) in patients with Graves'ophthalmopathy (GO). Here we further evaluate the haemodynamic change in GO patients after systemic steroid. Methods: In a prospective, interventional, consecutive clinical case series, all patients with active and moderately severe GO who underwent systemic steroid treatment were evaluated. The change of POBF and the clinical activity and severity of the disease were assessed. Results: In total, 11 patients underwent intravenous methylprednisolone pulse therapy followed by 2-month oral prednisolone therapy. POBF improved from a mean value of 476.5 to 614.7μl/min (P<0.001) after treatment. Likewise, the mean clinical activity score reduced from 4.8 to 1.6. However, systemic steroid had less effect on the severity of GO. It also revealed that there is a greater improvement of POBF in those with more clinical activity score (>4) at the onset. Conclusions: Following treatment with systemic steroid we have demonstrated a significant improvement in POBF in patients with GO.

Original languageEnglish
Pages (from-to)1025-1029
Number of pages5
JournalEye
Volume20
Issue number9
DOIs
Publication statusPublished - Jan 1 2006
Externally publishedYes

Fingerprint

Graves Ophthalmopathy
Steroids
Therapeutics
Methylprednisolone
Prednisolone
Hemodynamics
Blood

ASJC Scopus subject areas

  • Ophthalmology
  • Arts and Humanities(all)

Cite this

Pulsatile ocular blood flow change after treatment with systemic steroid in patients with Graves' ophthalmopathy. / Tsai, C. C.; Kau, H. C.; Tsai, H. H.; Kao, S. C.; Hsu, Wen-Ming.

In: Eye, Vol. 20, No. 9, 01.01.2006, p. 1025-1029.

Research output: Contribution to journalArticle

Tsai, C. C. ; Kau, H. C. ; Tsai, H. H. ; Kao, S. C. ; Hsu, Wen-Ming. / Pulsatile ocular blood flow change after treatment with systemic steroid in patients with Graves' ophthalmopathy. In: Eye. 2006 ; Vol. 20, No. 9. pp. 1025-1029.
@article{93cf49c2fbfb48749a25e498cfff71e6,
title = "Pulsatile ocular blood flow change after treatment with systemic steroid in patients with Graves' ophthalmopathy",
abstract = "Purpose: Our previous study has demonstrated an impairment of pulsatile ocular blood flow (POBF) in patients with Graves'ophthalmopathy (GO). Here we further evaluate the haemodynamic change in GO patients after systemic steroid. Methods: In a prospective, interventional, consecutive clinical case series, all patients with active and moderately severe GO who underwent systemic steroid treatment were evaluated. The change of POBF and the clinical activity and severity of the disease were assessed. Results: In total, 11 patients underwent intravenous methylprednisolone pulse therapy followed by 2-month oral prednisolone therapy. POBF improved from a mean value of 476.5 to 614.7μl/min (P<0.001) after treatment. Likewise, the mean clinical activity score reduced from 4.8 to 1.6. However, systemic steroid had less effect on the severity of GO. It also revealed that there is a greater improvement of POBF in those with more clinical activity score (>4) at the onset. Conclusions: Following treatment with systemic steroid we have demonstrated a significant improvement in POBF in patients with GO.",
author = "Tsai, {C. C.} and Kau, {H. C.} and Tsai, {H. H.} and Kao, {S. C.} and Wen-Ming Hsu",
year = "2006",
month = "1",
day = "1",
doi = "10.1038/sj.eye.6702070",
language = "English",
volume = "20",
pages = "1025--1029",
journal = "Eye",
issn = "0950-222X",
publisher = "Nature Publishing Group",
number = "9",

}

TY - JOUR

T1 - Pulsatile ocular blood flow change after treatment with systemic steroid in patients with Graves' ophthalmopathy

AU - Tsai, C. C.

AU - Kau, H. C.

AU - Tsai, H. H.

AU - Kao, S. C.

AU - Hsu, Wen-Ming

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Purpose: Our previous study has demonstrated an impairment of pulsatile ocular blood flow (POBF) in patients with Graves'ophthalmopathy (GO). Here we further evaluate the haemodynamic change in GO patients after systemic steroid. Methods: In a prospective, interventional, consecutive clinical case series, all patients with active and moderately severe GO who underwent systemic steroid treatment were evaluated. The change of POBF and the clinical activity and severity of the disease were assessed. Results: In total, 11 patients underwent intravenous methylprednisolone pulse therapy followed by 2-month oral prednisolone therapy. POBF improved from a mean value of 476.5 to 614.7μl/min (P<0.001) after treatment. Likewise, the mean clinical activity score reduced from 4.8 to 1.6. However, systemic steroid had less effect on the severity of GO. It also revealed that there is a greater improvement of POBF in those with more clinical activity score (>4) at the onset. Conclusions: Following treatment with systemic steroid we have demonstrated a significant improvement in POBF in patients with GO.

AB - Purpose: Our previous study has demonstrated an impairment of pulsatile ocular blood flow (POBF) in patients with Graves'ophthalmopathy (GO). Here we further evaluate the haemodynamic change in GO patients after systemic steroid. Methods: In a prospective, interventional, consecutive clinical case series, all patients with active and moderately severe GO who underwent systemic steroid treatment were evaluated. The change of POBF and the clinical activity and severity of the disease were assessed. Results: In total, 11 patients underwent intravenous methylprednisolone pulse therapy followed by 2-month oral prednisolone therapy. POBF improved from a mean value of 476.5 to 614.7μl/min (P<0.001) after treatment. Likewise, the mean clinical activity score reduced from 4.8 to 1.6. However, systemic steroid had less effect on the severity of GO. It also revealed that there is a greater improvement of POBF in those with more clinical activity score (>4) at the onset. Conclusions: Following treatment with systemic steroid we have demonstrated a significant improvement in POBF in patients with GO.

UR - http://www.scopus.com/inward/record.url?scp=33748424687&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748424687&partnerID=8YFLogxK

U2 - 10.1038/sj.eye.6702070

DO - 10.1038/sj.eye.6702070

M3 - Article

VL - 20

SP - 1025

EP - 1029

JO - Eye

JF - Eye

SN - 0950-222X

IS - 9

ER -