TY - JOUR
T1 - Pulsatile ocular blood flow change after treatment with systemic steroid in patients with Graves' ophthalmopathy
AU - Tsai, C. C.
AU - Kau, H. C.
AU - Tsai, H. H.
AU - Kao, S. C.
AU - Hsu, Wen-Ming
PY - 2006/1/1
Y1 - 2006/1/1
N2 - Purpose: Our previous study has demonstrated an impairment of pulsatile ocular blood flow (POBF) in patients with Graves'ophthalmopathy (GO). Here we further evaluate the haemodynamic change in GO patients after systemic steroid. Methods: In a prospective, interventional, consecutive clinical case series, all patients with active and moderately severe GO who underwent systemic steroid treatment were evaluated. The change of POBF and the clinical activity and severity of the disease were assessed. Results: In total, 11 patients underwent intravenous methylprednisolone pulse therapy followed by 2-month oral prednisolone therapy. POBF improved from a mean value of 476.5 to 614.7μl/min (P<0.001) after treatment. Likewise, the mean clinical activity score reduced from 4.8 to 1.6. However, systemic steroid had less effect on the severity of GO. It also revealed that there is a greater improvement of POBF in those with more clinical activity score (>4) at the onset. Conclusions: Following treatment with systemic steroid we have demonstrated a significant improvement in POBF in patients with GO.
AB - Purpose: Our previous study has demonstrated an impairment of pulsatile ocular blood flow (POBF) in patients with Graves'ophthalmopathy (GO). Here we further evaluate the haemodynamic change in GO patients after systemic steroid. Methods: In a prospective, interventional, consecutive clinical case series, all patients with active and moderately severe GO who underwent systemic steroid treatment were evaluated. The change of POBF and the clinical activity and severity of the disease were assessed. Results: In total, 11 patients underwent intravenous methylprednisolone pulse therapy followed by 2-month oral prednisolone therapy. POBF improved from a mean value of 476.5 to 614.7μl/min (P<0.001) after treatment. Likewise, the mean clinical activity score reduced from 4.8 to 1.6. However, systemic steroid had less effect on the severity of GO. It also revealed that there is a greater improvement of POBF in those with more clinical activity score (>4) at the onset. Conclusions: Following treatment with systemic steroid we have demonstrated a significant improvement in POBF in patients with GO.
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U2 - 10.1038/sj.eye.6702070
DO - 10.1038/sj.eye.6702070
M3 - Article
C2 - 16123781
AN - SCOPUS:33748424687
SN - 0950-222X
VL - 20
SP - 1025
EP - 1029
JO - Transactions of the Ophthalmological Societies of the United Kingdom
JF - Transactions of the Ophthalmological Societies of the United Kingdom
IS - 9
ER -