Pulmonary vein electrogram characteristics in patients with focal sources of paroxysmal atrial fibrillation

Ming-Hsiung Hsieh, Ching T. Tai, Chin Feng Tsai, Wen Chung Yu, Shih Huang Lee, Yung-Kuo Lin, Yu An Ding, Mau Song Chang, Shih A. Chen

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Introduction: The major source of ectopic beats initiating paroxysmal atrial fibrillation (AF) is from pulmonary veins (PVs). However, the electrogram characteristics of PVs are not well defined. Methods and Results: Group I consisted of 129 patients with paroxysmal AF. Group II consisted of 10 patients with a concealed left-sided free-wall accessory pathway. All group I patients had spontaneous AF initiated by ectopic beats, including 169 ectopic foci originating from the PVs. We analyzed PV electrograms from the 169 ectopic foci during sinus beats and ectopic beats. During AF initiation, most (70%) ectopic beats showed PV spike potential followed by atrial potential; 16% of ectopic beats showed PV fragmented potential followed by atrial potential; and 14% showed fusion potentials. The coupling interval between the sinus beat and the ectopic beat was significantly shorter in the inferior PVs than in the superior PVs (171 ± 48 msec vs 222 ± 63 msec, P = 0.001) and was significantly shorter in the distal foci than in the ostial foci of PVs (206 ± 52 msec vs 230 ± 56 msec, P = 0.01). The incidence of conduction block in the PVs during AF initiation was significantly higher in the inferior PVs than in the superior PVs (12/24 vs 37/145, P = 0.03) and was significantly higher in the distal foci than in the ostial foci of PVs (43/121 vs 6/48, P = 0.04). The maximal amplitude of PV potential was significantly larger in the left PVs than in the right PVs, and the maximal duration of PV potential was significantly longer in the superior PVs than in the inferior PVs during sinus beats in both group I and II patients. Conclusion: PV electrogram characteristics were different among the four PVs. Detailed mapping and careful interpretation are the most important steps in ablation of paroxysmal AF originating from PVs.

Original languageEnglish
Pages (from-to)953-959
Number of pages7
JournalJournal of Cardiovascular Electrophysiology
Volume11
Issue number9
Publication statusPublished - 2000

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Pulmonary Veins
Atrial Fibrillation

Keywords

  • Atrial fibrillation
  • Catheter ablation
  • Pulmonary vein

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Pulmonary vein electrogram characteristics in patients with focal sources of paroxysmal atrial fibrillation. / Hsieh, Ming-Hsiung; Tai, Ching T.; Tsai, Chin Feng; Yu, Wen Chung; Lee, Shih Huang; Lin, Yung-Kuo; Ding, Yu An; Chang, Mau Song; Chen, Shih A.

In: Journal of Cardiovascular Electrophysiology, Vol. 11, No. 9, 2000, p. 953-959.

Research output: Contribution to journalArticle

Hsieh, Ming-Hsiung ; Tai, Ching T. ; Tsai, Chin Feng ; Yu, Wen Chung ; Lee, Shih Huang ; Lin, Yung-Kuo ; Ding, Yu An ; Chang, Mau Song ; Chen, Shih A. / Pulmonary vein electrogram characteristics in patients with focal sources of paroxysmal atrial fibrillation. In: Journal of Cardiovascular Electrophysiology. 2000 ; Vol. 11, No. 9. pp. 953-959.
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abstract = "Introduction: The major source of ectopic beats initiating paroxysmal atrial fibrillation (AF) is from pulmonary veins (PVs). However, the electrogram characteristics of PVs are not well defined. Methods and Results: Group I consisted of 129 patients with paroxysmal AF. Group II consisted of 10 patients with a concealed left-sided free-wall accessory pathway. All group I patients had spontaneous AF initiated by ectopic beats, including 169 ectopic foci originating from the PVs. We analyzed PV electrograms from the 169 ectopic foci during sinus beats and ectopic beats. During AF initiation, most (70{\%}) ectopic beats showed PV spike potential followed by atrial potential; 16{\%} of ectopic beats showed PV fragmented potential followed by atrial potential; and 14{\%} showed fusion potentials. The coupling interval between the sinus beat and the ectopic beat was significantly shorter in the inferior PVs than in the superior PVs (171 ± 48 msec vs 222 ± 63 msec, P = 0.001) and was significantly shorter in the distal foci than in the ostial foci of PVs (206 ± 52 msec vs 230 ± 56 msec, P = 0.01). The incidence of conduction block in the PVs during AF initiation was significantly higher in the inferior PVs than in the superior PVs (12/24 vs 37/145, P = 0.03) and was significantly higher in the distal foci than in the ostial foci of PVs (43/121 vs 6/48, P = 0.04). The maximal amplitude of PV potential was significantly larger in the left PVs than in the right PVs, and the maximal duration of PV potential was significantly longer in the superior PVs than in the inferior PVs during sinus beats in both group I and II patients. Conclusion: PV electrogram characteristics were different among the four PVs. Detailed mapping and careful interpretation are the most important steps in ablation of paroxysmal AF originating from PVs.",
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T1 - Pulmonary vein electrogram characteristics in patients with focal sources of paroxysmal atrial fibrillation

AU - Hsieh, Ming-Hsiung

AU - Tai, Ching T.

AU - Tsai, Chin Feng

AU - Yu, Wen Chung

AU - Lee, Shih Huang

AU - Lin, Yung-Kuo

AU - Ding, Yu An

AU - Chang, Mau Song

AU - Chen, Shih A.

PY - 2000

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N2 - Introduction: The major source of ectopic beats initiating paroxysmal atrial fibrillation (AF) is from pulmonary veins (PVs). However, the electrogram characteristics of PVs are not well defined. Methods and Results: Group I consisted of 129 patients with paroxysmal AF. Group II consisted of 10 patients with a concealed left-sided free-wall accessory pathway. All group I patients had spontaneous AF initiated by ectopic beats, including 169 ectopic foci originating from the PVs. We analyzed PV electrograms from the 169 ectopic foci during sinus beats and ectopic beats. During AF initiation, most (70%) ectopic beats showed PV spike potential followed by atrial potential; 16% of ectopic beats showed PV fragmented potential followed by atrial potential; and 14% showed fusion potentials. The coupling interval between the sinus beat and the ectopic beat was significantly shorter in the inferior PVs than in the superior PVs (171 ± 48 msec vs 222 ± 63 msec, P = 0.001) and was significantly shorter in the distal foci than in the ostial foci of PVs (206 ± 52 msec vs 230 ± 56 msec, P = 0.01). The incidence of conduction block in the PVs during AF initiation was significantly higher in the inferior PVs than in the superior PVs (12/24 vs 37/145, P = 0.03) and was significantly higher in the distal foci than in the ostial foci of PVs (43/121 vs 6/48, P = 0.04). The maximal amplitude of PV potential was significantly larger in the left PVs than in the right PVs, and the maximal duration of PV potential was significantly longer in the superior PVs than in the inferior PVs during sinus beats in both group I and II patients. Conclusion: PV electrogram characteristics were different among the four PVs. Detailed mapping and careful interpretation are the most important steps in ablation of paroxysmal AF originating from PVs.

AB - Introduction: The major source of ectopic beats initiating paroxysmal atrial fibrillation (AF) is from pulmonary veins (PVs). However, the electrogram characteristics of PVs are not well defined. Methods and Results: Group I consisted of 129 patients with paroxysmal AF. Group II consisted of 10 patients with a concealed left-sided free-wall accessory pathway. All group I patients had spontaneous AF initiated by ectopic beats, including 169 ectopic foci originating from the PVs. We analyzed PV electrograms from the 169 ectopic foci during sinus beats and ectopic beats. During AF initiation, most (70%) ectopic beats showed PV spike potential followed by atrial potential; 16% of ectopic beats showed PV fragmented potential followed by atrial potential; and 14% showed fusion potentials. The coupling interval between the sinus beat and the ectopic beat was significantly shorter in the inferior PVs than in the superior PVs (171 ± 48 msec vs 222 ± 63 msec, P = 0.001) and was significantly shorter in the distal foci than in the ostial foci of PVs (206 ± 52 msec vs 230 ± 56 msec, P = 0.01). The incidence of conduction block in the PVs during AF initiation was significantly higher in the inferior PVs than in the superior PVs (12/24 vs 37/145, P = 0.03) and was significantly higher in the distal foci than in the ostial foci of PVs (43/121 vs 6/48, P = 0.04). The maximal amplitude of PV potential was significantly larger in the left PVs than in the right PVs, and the maximal duration of PV potential was significantly longer in the superior PVs than in the inferior PVs during sinus beats in both group I and II patients. Conclusion: PV electrogram characteristics were different among the four PVs. Detailed mapping and careful interpretation are the most important steps in ablation of paroxysmal AF originating from PVs.

KW - Atrial fibrillation

KW - Catheter ablation

KW - Pulmonary vein

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