Pulmonary Tuberculosis and delay in anti-tuberculous treatment are important risk factors for chronic obstructive pulmonary disease

Chih Hsin Lee, Ming Chia Lee, Hsien Ho Lin, Chin Chung Shu, Jann Yuan Wang, Li Na Lee, Kun Mao Chao

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Objective: Tuberculosis (TB) remains the leading cause of death among infectious diseases worldwide. It has been suggested as an important risk factor of chronic obstructive pulmonary disease (COPD), which is also a major cause of morbidity and mortality. This study investigated the impact of pulmonary TB and anti-TB treatment on the risk of developing COPD. Design, Setting, and Participants: This cohort study used the National Health Insurance Database of Taiwan, particularly the Longitudinal Health Insurance Database 2005 to obtain 3,176 pulmonary TB cases and 15,880 control subjects matched in age, sex, and timing of entering the database. Main Outcome Measures: Hazard ratios of potential risk factors of COPD, especially pulmonary TB and anti-TB treatment. Results: The mean age of pulmonary TB cases was 51.9±19.2. The interval between the initial study date and commencement of anti-TB treatment (delay in anti-TB treatment) was 75.8±65.4 days. Independent risk factors for developing COPD were age, male, low income, and history of pulmonary TB (hazard ratio 2.054 [1.768-2.387]), while diabetes mellitus was protective. The impact of TB persisted for six years after TB diagnosis and was significant in women and subjects aged >70 years. Among TB patients, delay in anti-TB treatment had a dose-response relationship with the risk of developing COPD. Conclusions: Some cases of COPD may be preventable by controlling the TB epidemic, early TB diagnosis, and prompt initiation of appropriate anti-TB treatment. Follow-up care and early intervention for COPD may be necessary for treated TB patients.

Original languageEnglish
Article numbere37978
JournalPLoS One
Volume7
Issue number5
DOIs
Publication statusPublished - May 25 2012
Externally publishedYes

Fingerprint

Pulmonary diseases
Pulmonary Tuberculosis
tuberculosis
respiratory tract diseases
Chronic Obstructive Pulmonary Disease
Tuberculosis
risk factors
lungs
Health insurance
Therapeutics
Hazards
Databases
Medical problems
health insurance
Aftercare
National Health Programs
Health Insurance
Taiwan
Communicable Diseases
Early Diagnosis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Pulmonary Tuberculosis and delay in anti-tuberculous treatment are important risk factors for chronic obstructive pulmonary disease. / Lee, Chih Hsin; Lee, Ming Chia; Lin, Hsien Ho; Shu, Chin Chung; Wang, Jann Yuan; Lee, Li Na; Chao, Kun Mao.

In: PLoS One, Vol. 7, No. 5, e37978, 25.05.2012.

Research output: Contribution to journalArticle

Lee, Chih Hsin ; Lee, Ming Chia ; Lin, Hsien Ho ; Shu, Chin Chung ; Wang, Jann Yuan ; Lee, Li Na ; Chao, Kun Mao. / Pulmonary Tuberculosis and delay in anti-tuberculous treatment are important risk factors for chronic obstructive pulmonary disease. In: PLoS One. 2012 ; Vol. 7, No. 5.
@article{1296cafe91364692a5c5e88c10626a9f,
title = "Pulmonary Tuberculosis and delay in anti-tuberculous treatment are important risk factors for chronic obstructive pulmonary disease",
abstract = "Objective: Tuberculosis (TB) remains the leading cause of death among infectious diseases worldwide. It has been suggested as an important risk factor of chronic obstructive pulmonary disease (COPD), which is also a major cause of morbidity and mortality. This study investigated the impact of pulmonary TB and anti-TB treatment on the risk of developing COPD. Design, Setting, and Participants: This cohort study used the National Health Insurance Database of Taiwan, particularly the Longitudinal Health Insurance Database 2005 to obtain 3,176 pulmonary TB cases and 15,880 control subjects matched in age, sex, and timing of entering the database. Main Outcome Measures: Hazard ratios of potential risk factors of COPD, especially pulmonary TB and anti-TB treatment. Results: The mean age of pulmonary TB cases was 51.9±19.2. The interval between the initial study date and commencement of anti-TB treatment (delay in anti-TB treatment) was 75.8±65.4 days. Independent risk factors for developing COPD were age, male, low income, and history of pulmonary TB (hazard ratio 2.054 [1.768-2.387]), while diabetes mellitus was protective. The impact of TB persisted for six years after TB diagnosis and was significant in women and subjects aged >70 years. Among TB patients, delay in anti-TB treatment had a dose-response relationship with the risk of developing COPD. Conclusions: Some cases of COPD may be preventable by controlling the TB epidemic, early TB diagnosis, and prompt initiation of appropriate anti-TB treatment. Follow-up care and early intervention for COPD may be necessary for treated TB patients.",
author = "Lee, {Chih Hsin} and Lee, {Ming Chia} and Lin, {Hsien Ho} and Shu, {Chin Chung} and Wang, {Jann Yuan} and Lee, {Li Na} and Chao, {Kun Mao}",
year = "2012",
month = "5",
day = "25",
doi = "10.1371/journal.pone.0037978",
language = "English",
volume = "7",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",

}

TY - JOUR

T1 - Pulmonary Tuberculosis and delay in anti-tuberculous treatment are important risk factors for chronic obstructive pulmonary disease

AU - Lee, Chih Hsin

AU - Lee, Ming Chia

AU - Lin, Hsien Ho

AU - Shu, Chin Chung

AU - Wang, Jann Yuan

AU - Lee, Li Na

AU - Chao, Kun Mao

PY - 2012/5/25

Y1 - 2012/5/25

N2 - Objective: Tuberculosis (TB) remains the leading cause of death among infectious diseases worldwide. It has been suggested as an important risk factor of chronic obstructive pulmonary disease (COPD), which is also a major cause of morbidity and mortality. This study investigated the impact of pulmonary TB and anti-TB treatment on the risk of developing COPD. Design, Setting, and Participants: This cohort study used the National Health Insurance Database of Taiwan, particularly the Longitudinal Health Insurance Database 2005 to obtain 3,176 pulmonary TB cases and 15,880 control subjects matched in age, sex, and timing of entering the database. Main Outcome Measures: Hazard ratios of potential risk factors of COPD, especially pulmonary TB and anti-TB treatment. Results: The mean age of pulmonary TB cases was 51.9±19.2. The interval between the initial study date and commencement of anti-TB treatment (delay in anti-TB treatment) was 75.8±65.4 days. Independent risk factors for developing COPD were age, male, low income, and history of pulmonary TB (hazard ratio 2.054 [1.768-2.387]), while diabetes mellitus was protective. The impact of TB persisted for six years after TB diagnosis and was significant in women and subjects aged >70 years. Among TB patients, delay in anti-TB treatment had a dose-response relationship with the risk of developing COPD. Conclusions: Some cases of COPD may be preventable by controlling the TB epidemic, early TB diagnosis, and prompt initiation of appropriate anti-TB treatment. Follow-up care and early intervention for COPD may be necessary for treated TB patients.

AB - Objective: Tuberculosis (TB) remains the leading cause of death among infectious diseases worldwide. It has been suggested as an important risk factor of chronic obstructive pulmonary disease (COPD), which is also a major cause of morbidity and mortality. This study investigated the impact of pulmonary TB and anti-TB treatment on the risk of developing COPD. Design, Setting, and Participants: This cohort study used the National Health Insurance Database of Taiwan, particularly the Longitudinal Health Insurance Database 2005 to obtain 3,176 pulmonary TB cases and 15,880 control subjects matched in age, sex, and timing of entering the database. Main Outcome Measures: Hazard ratios of potential risk factors of COPD, especially pulmonary TB and anti-TB treatment. Results: The mean age of pulmonary TB cases was 51.9±19.2. The interval between the initial study date and commencement of anti-TB treatment (delay in anti-TB treatment) was 75.8±65.4 days. Independent risk factors for developing COPD were age, male, low income, and history of pulmonary TB (hazard ratio 2.054 [1.768-2.387]), while diabetes mellitus was protective. The impact of TB persisted for six years after TB diagnosis and was significant in women and subjects aged >70 years. Among TB patients, delay in anti-TB treatment had a dose-response relationship with the risk of developing COPD. Conclusions: Some cases of COPD may be preventable by controlling the TB epidemic, early TB diagnosis, and prompt initiation of appropriate anti-TB treatment. Follow-up care and early intervention for COPD may be necessary for treated TB patients.

UR - http://www.scopus.com/inward/record.url?scp=84861475738&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861475738&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0037978

DO - 10.1371/journal.pone.0037978

M3 - Article

VL - 7

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 5

M1 - e37978

ER -