Pulmonary NAD+-linked 15-hydroxyprostaglandin dehydrogenase activity is decreased by cigarette smoking

Wen Chang Chang, Shoshi Fukuda, Hsin Hsiung Tai

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7 Citations (Scopus)

Abstract

Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 13 weeks. Inhalation of smoke was verified by elevated level of carboxyhemoglobin. NAD+-dependent 15-hydroxyprostaglandin dehydrogenase activity, the key enzyme responsible for biological inactivation of prostaglandins, was found to decrease in lung but not in kidney or stomach following cigarette smoke exposure. The consequence of impaired pulmonary metobolism of prostaglandins and thromboxane may result in alteration of vascular homeostasis and subsequently lead to cardiovascular disorders commonly found in smokers.

Original languageEnglish
Pages (from-to)1261-1268
Number of pages8
JournalLife Sciences
Volume34
Issue number13
DOIs
Publication statusPublished - Mar 26 1984
Externally publishedYes

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ASJC Scopus subject areas

  • Pharmacology

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