Pulmonary metastasectomy for hepatocellular carcinoma

Yo Ju Chen, Han Shui Hsu, Chih Cheng Hsieh, Yu Chung Wu, Liang Shun Wang, Wen Hu Hsu, Min Hsiung Huang, Biing Shiun Huang

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background. Hepatocellular carcinoma (HCC) is seldom resectable due to advanced status. Even though hepatectomy is feasible, a large proportional of patients may still develops extrahepatic recurrence. Pulmonary metastasis is the most common site of extrahepatic spread. Few articles have discussed the benefit of resection for lung metastasis after curative hepatectomy. We evaluated the general information and the result of lung resection for patients having lung metastasis after curative resection of HCC. Methods. Six patients who underwent pulmonary metastasectomy for HCC at Taipei Veterans General Hospital between August 1995 and May 2004 were enrolled in the study. All of them had received the hepatectomy for primary HCC. The demographic information of patients, the site and number of extrahepatic recurrence, the method of surgical intervention and the outcome after surgery were retrospectively reviewed. Results. There were 4 men and 2 women with the mean age of 47.3 years. All of them were HBV carriers. Five patients had multiple pulmonary metastases removed by wedge resection. Two patients had bilateral lung metastases upon diagnosis of extrahepatic recurrence. The mean duration of follow-up after hepatic resection was 75.0 ± 25.1 months (32 to 104 months). The mean survival after pulmonary resection was 47.2 ± 34.3months (1 to 94 months). Four patients are still alive and free of the disease. One patient is alive but with the disease. One patient who refused further aggressive treatment after resection of lung metastasis died of the disease 40 months after lung resection, 77 months after hepatic resection. Conclusions. Lung resection for the pulmonary metastasis of HCC can result in a favorable long-term survival when there is no other intrahepatic or extraphepatic recurrence of HCC. For patients with multiple lung metastases in different lobes or different lungs, aggressive surgical resection is recommended if complete resection can be achieved.

Original languageEnglish
Pages (from-to)621-624
Number of pages4
JournalJournal of the Chinese Medical Association
Volume67
Issue number12
Publication statusPublished - Dec 2004
Externally publishedYes

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Metastasectomy
Hepatocellular Carcinoma
Lung
Neoplasm Metastasis
Hepatectomy
Recurrence
Veterans Hospitals
Survival
Liver

Keywords

  • Hepatocellular carcinoma
  • Lung metastasis
  • Resection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Chen, Y. J., Hsu, H. S., Hsieh, C. C., Wu, Y. C., Wang, L. S., Hsu, W. H., ... Huang, B. S. (2004). Pulmonary metastasectomy for hepatocellular carcinoma. Journal of the Chinese Medical Association, 67(12), 621-624.

Pulmonary metastasectomy for hepatocellular carcinoma. / Chen, Yo Ju; Hsu, Han Shui; Hsieh, Chih Cheng; Wu, Yu Chung; Wang, Liang Shun; Hsu, Wen Hu; Huang, Min Hsiung; Huang, Biing Shiun.

In: Journal of the Chinese Medical Association, Vol. 67, No. 12, 12.2004, p. 621-624.

Research output: Contribution to journalArticle

Chen, YJ, Hsu, HS, Hsieh, CC, Wu, YC, Wang, LS, Hsu, WH, Huang, MH & Huang, BS 2004, 'Pulmonary metastasectomy for hepatocellular carcinoma', Journal of the Chinese Medical Association, vol. 67, no. 12, pp. 621-624.
Chen YJ, Hsu HS, Hsieh CC, Wu YC, Wang LS, Hsu WH et al. Pulmonary metastasectomy for hepatocellular carcinoma. Journal of the Chinese Medical Association. 2004 Dec;67(12):621-624.
Chen, Yo Ju ; Hsu, Han Shui ; Hsieh, Chih Cheng ; Wu, Yu Chung ; Wang, Liang Shun ; Hsu, Wen Hu ; Huang, Min Hsiung ; Huang, Biing Shiun. / Pulmonary metastasectomy for hepatocellular carcinoma. In: Journal of the Chinese Medical Association. 2004 ; Vol. 67, No. 12. pp. 621-624.
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AU - Hsieh, Chih Cheng

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AU - Huang, Min Hsiung

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N2 - Background. Hepatocellular carcinoma (HCC) is seldom resectable due to advanced status. Even though hepatectomy is feasible, a large proportional of patients may still develops extrahepatic recurrence. Pulmonary metastasis is the most common site of extrahepatic spread. Few articles have discussed the benefit of resection for lung metastasis after curative hepatectomy. We evaluated the general information and the result of lung resection for patients having lung metastasis after curative resection of HCC. Methods. Six patients who underwent pulmonary metastasectomy for HCC at Taipei Veterans General Hospital between August 1995 and May 2004 were enrolled in the study. All of them had received the hepatectomy for primary HCC. The demographic information of patients, the site and number of extrahepatic recurrence, the method of surgical intervention and the outcome after surgery were retrospectively reviewed. Results. There were 4 men and 2 women with the mean age of 47.3 years. All of them were HBV carriers. Five patients had multiple pulmonary metastases removed by wedge resection. Two patients had bilateral lung metastases upon diagnosis of extrahepatic recurrence. The mean duration of follow-up after hepatic resection was 75.0 ± 25.1 months (32 to 104 months). The mean survival after pulmonary resection was 47.2 ± 34.3months (1 to 94 months). Four patients are still alive and free of the disease. One patient is alive but with the disease. One patient who refused further aggressive treatment after resection of lung metastasis died of the disease 40 months after lung resection, 77 months after hepatic resection. Conclusions. Lung resection for the pulmonary metastasis of HCC can result in a favorable long-term survival when there is no other intrahepatic or extraphepatic recurrence of HCC. For patients with multiple lung metastases in different lobes or different lungs, aggressive surgical resection is recommended if complete resection can be achieved.

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