Pulmonary CYP2A13 levels are associated with early occurrence of lung cancer-Its implication in mutagenesis of non-small cell lung carcinoma

Huai chih Chiang, Huei Lee, How Ran Chao, Yu Hu Chiou, Tsui Chun Tsou

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

CYP2A13, a human pulmonary specific cytochrome P450 enzyme, plays an important role in susceptibility to tobacco-specific nitrosamines (TSNAs)-induced lung cancer in humans. The pattern of CYP2A13 distribution in respiratory tract affects the susceptibility of the lung to carcinogens. CYP2A13 is expressed in the epithelium of trachea and bronchi; however its pattern of expression in human lung cancer remains largely unknown. This study aimed to determine the CYP2A13 expression in specimens from human non-small cell lung carcinomas (NSCLCs), i.e., adenocarcinoma and squamous carcinoma, by immunohistochemical (IHC) analysis and to identify the potential linkage between tumor CYP2A13 levels and some clinicopathological characteristics of NSCLC patients in Taiwan. The tumor CYP2A13 IHC staining signal was strong in 76% of the 112 study subjects. Study subjects (especially non-smoking or lung adenocarcinoma patients) with higher tumor CYP2A13 levels were younger. Multiple logistic regression analysis revealed that in younger subjects (age ≤ 66) and heavy smokers (pack-years ≥ 40), the odds ratio (OR) for positive tumor CYP2A13 staining was significantly higher than that for negative tumor CYP2A13 staining. Moreover, the association of EGFR gene mutations and positive tumor CYP2A13 staining was also revealed. In conclusion, these findings suggest the potential involvement of pulmonary CYP2A13 in the early occurrence of NSCLC as well as in the development of EGFR gene mutations.

Original languageEnglish
Pages (from-to)653-659
Number of pages7
JournalCancer Epidemiology
Volume37
Issue number5
DOIs
Publication statusPublished - Oct 2013

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Non-Small Cell Lung Carcinoma
Mutagenesis
Lung Neoplasms
Lung
Staining and Labeling
erbB-1 Genes
Neoplasms
Cytochrome P-450 Enzyme System
Nitrosamines
Mutation
Bronchi
Trachea
Taiwan
Respiratory System
Carcinogens
Tobacco
Squamous Cell Carcinoma
Adenocarcinoma
Epithelium
Logistic Models

Keywords

  • CYP2A13
  • Early occurrence
  • EGFR mutations
  • IHC
  • Lung cancer
  • NSCLC

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology

Cite this

Pulmonary CYP2A13 levels are associated with early occurrence of lung cancer-Its implication in mutagenesis of non-small cell lung carcinoma. / Chiang, Huai chih; Lee, Huei; Chao, How Ran; Chiou, Yu Hu; Tsou, Tsui Chun.

In: Cancer Epidemiology, Vol. 37, No. 5, 10.2013, p. 653-659.

Research output: Contribution to journalArticle

Chiang, Huai chih ; Lee, Huei ; Chao, How Ran ; Chiou, Yu Hu ; Tsou, Tsui Chun. / Pulmonary CYP2A13 levels are associated with early occurrence of lung cancer-Its implication in mutagenesis of non-small cell lung carcinoma. In: Cancer Epidemiology. 2013 ; Vol. 37, No. 5. pp. 653-659.
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