Psychophysiological effects of lactobacillus plantarum ps128 in patients with major depressive disorder: A preliminary 8-week open trial

Hui Mei Chen, Po Hsiu Kuo, Chia Yueh Hsu, Yi Hung Chiu, Yen Wenn Liu, Mong Liang Lu, Chun Hsin Chen

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Recent studies have suggested that gut–brain axis may be one of the mechanisms of major depression disorder (MDD). The current study aimed to investigate the effects of Lactobacillus planta-rum PS128 (PS128) on psychophysiology in patients with MDD. We recruited 11 patients with MDD and gave them PS128 for 8 weeks. We compared depression symptoms, serum markers of inflammation and gut permeability, and gut microbiota before and after 8-week intervention and also explored the correlations among symptoms, biomarkers, and gut microbiota. After 8-week PS128 intervention, scores of Hamilton Depression Rating Scale-17 and Depression and Somatic symptoms Scale significantly decreased. Serum levels of high sensitivity c-reactive protein, interluekin-6, and tumor necrosis factor-α, zonulin and intestinal fatty acid binding protein, and the composition of gut microbiota did not significantly change after 8-week PS128 intervention. However, we found changes of some genera were correlated with changes of symptoms and biomarkers. In con-clusion, this is an open trial with small sample size and has several limitations. The results need to be verified by randomized, double-blind, placebo-controlled trial with larger sample size.

Original languageEnglish
Article number3731
JournalNutrients
Volume13
Issue number11
DOIs
Publication statusPublished - Nov 2021

Keywords

  • Gut permeability
  • Inflammation
  • Major depressive disorder
  • Microbiota
  • Probiotics

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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