Psoriasis and the risk of pneumonia

A population-based study

Li Ting Kao, Cha Ze Lee, Shih Ping Liu, Ming Chieh Tsai, Herng Ching Lin

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Psoriasis is a prevalent autoimmune disorder. Various studies have reported on the relationship between psoriasis and chronic diseases but very few have explored the association between psoriasis and subsequent acute infection. This retrospective cohort study aimed to compare the risk of pneumonia between subjects with and those without psoriasis. Methods: The medical records of 14,022 patients with psoriasis and 14,022 without psoriasis were obtained from the Taiwan Longitudinal Health Insurance Database 2000. Each patient was followed-up for a three-year period. Cox proportional hazard regressions were performed to compare difference of subsequent pneumonia incidence between subjects with and those without psoriasis. Results: There were 206 (1.47%) subjects with psoriasis and 138 (0.98%) without psoriasis hospitalized for pneumonia. By Cox proportional hazard regressions analysis, the HR (hazard ratio) of pneumonia requiring hospitalization for patients with psoriasis was 1.50 (95% confidence interval [CI]: 1.21-1.86) compared to patients without psoriasis. The adjusted HR was 1.40 (95% CI: 1.12-1.73). The adjusted HR of pneumonia hospitalization for subjects with mild and severe psoriasis was 1.36 (95% CI: 1.09-1.70) and 1.68 (95% CI: 1.12-2.52), respectively, compared to those without psoriasis. Conclusions: Patients with psoriasis have significantly higher incidence of pneumonia compared to those without psoriasis.

Original languageEnglish
Article numbere116077
JournalPLoS One
Volume9
Issue number12
DOIs
Publication statusPublished - Dec 26 2014

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psoriasis
Psoriasis
pneumonia
Pneumonia
Hazards
Population
Health insurance
confidence interval
Regression analysis
Confidence Intervals
Hospitalization
health insurance
incidence
Incidence
Health Insurance

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Psoriasis and the risk of pneumonia : A population-based study. / Kao, Li Ting; Lee, Cha Ze; Liu, Shih Ping; Tsai, Ming Chieh; Lin, Herng Ching.

In: PLoS One, Vol. 9, No. 12, e116077, 26.12.2014.

Research output: Contribution to journalArticle

Kao, Li Ting ; Lee, Cha Ze ; Liu, Shih Ping ; Tsai, Ming Chieh ; Lin, Herng Ching. / Psoriasis and the risk of pneumonia : A population-based study. In: PLoS One. 2014 ; Vol. 9, No. 12.
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