Proton magnetic resonance spectroscopy-guided biopsy for cerebral glial tumors

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Background and Purpose: Although application of proton magnetic resonance (MR) spectroscopy in the diagnosis of brain tumors has been reported, the role of this technique as guidance for targeting biopsy of brain tumors is not well established. The usefulness and limitations of predicting tumor proliferative activity and pathological grading of brain gliomas based on samples obtained front proton MR spectroscopy-guided stereotactic biopsy also remains unclear. The purpose of this study was to evaluate the usefulness of single-voxel MR spectroscopy-guided stereotactic biopsy for cerebral gliomas and to correlate the findings of MR spectroscopy with proliferative activity (measured by Ki-67 labeling index) of tumors and pathological diagnosis. Methods: Localized proton spectra were obtained before stereotactic/surgical biopsy in 7 patients with glioma (8 lesions). Metabolic values in the spectra were measured semiquantitatively and correlated with the Ki-67 labeling index and pathological grade of each surgical specimen. Results: MR spectroscopy-guided biopsy was effective in obtaining a representative specimen for accurate pathological diagnosis in all patients, including 1 patient with multifocal glioma and 2 with diffusely infiltrated gliomas (gliomatosis cerebri). Those lesions with higher choline complex/creatine ratio (Cho/Cr) and lower N-acetyl-L-aspartate/creatine values in MR spectroscopy were higher grade tumors. Higher Ki-67 labeling index (indicating higher proliferative activity of tumor) with higher Cho/Cr ratios in MR spectroscopy were significantly correlated with tumor grade. Conclusions: MR spectroscopy-guided biopsy was effective in obtaining a representative specimen for accurate pathological diagnosis, and the Clio/Cr ratio of MR spectra and Ki-67 labeling index were reliable predictors of glioma grade.

Original languageEnglish
Pages (from-to)448-458
Number of pages11
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Issue number6
Publication statusPublished - Jun 2004



  • Brain neoplasms
  • Ki-67 antigen
  • Magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Medicine(all)

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