Prothymosin α overexpression contributes to the development of pulmonary emphysema

Bing Hua Su, Yau Lin Tseng, Gia Shing Shieh, Yi Cheng Chen, Ya Chieh Shiang, Pensee Wu, Kuo Jung Li, Te Hsin Yen, Ai Li Shiau, Chao Liang Wu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Emphysema is one of the disease conditions that comprise chronic obstructive pulmonary disease. Prothymosin α transgenic mice exhibit an emphysema phenotype, but the pathophysiological role of prothymosin α in emphysema remains unclear. Here we show that prothymosin α contributes to the pathogenesis of emphysema by increasing acetylation of histones and nuclear factor-kappaB, particularly upon cigarette smoke exposure. We find a positive correlation between prothymosin α levels and the severity of emphysema in prothymosin α transgenic mice and emphysema patients. Prothymosin α overexpression increases susceptibility to cigarette smoke-induced emphysema, and cigarette smoke exposure further enhances prothymosin α expression. We show that prothymosin α inhibits the association of histone deacetylases with histones and nuclear factor-kappaB, and that prothymosin α overexpression increases expression of nuclear factor-kappaB-dependent matrix metalloproteinase 2 and matrix metalloproteinase 9, which are found in the lungs of patients with chronic obstructive pulmonary disease. These results demonstrate the clinical relevance of prothymosin α in regulating acetylation events during the pathogenesis of emphysema.

Original languageEnglish
Article number1906
JournalNature Communications
Volume4
DOIs
Publication statusPublished - Jun 12 2013

Fingerprint

emphysema
Pulmonary Emphysema
Emphysema
Smoke
Tobacco Products
Acetylation
Pulmonary diseases
Histones
smoke
Histone Deacetylases
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
acetylation
pathogenesis
Association reactions
Chronic Obstructive Pulmonary Disease
Transgenic Mice
mice
phenotype
matrices

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Prothymosin α overexpression contributes to the development of pulmonary emphysema. / Su, Bing Hua; Tseng, Yau Lin; Shieh, Gia Shing; Chen, Yi Cheng; Shiang, Ya Chieh; Wu, Pensee; Li, Kuo Jung; Yen, Te Hsin; Shiau, Ai Li; Wu, Chao Liang.

In: Nature Communications, Vol. 4, 1906, 12.06.2013.

Research output: Contribution to journalArticle

Su, BH, Tseng, YL, Shieh, GS, Chen, YC, Shiang, YC, Wu, P, Li, KJ, Yen, TH, Shiau, AL & Wu, CL 2013, 'Prothymosin α overexpression contributes to the development of pulmonary emphysema', Nature Communications, vol. 4, 1906. https://doi.org/10.1038/ncomms2906
Su, Bing Hua ; Tseng, Yau Lin ; Shieh, Gia Shing ; Chen, Yi Cheng ; Shiang, Ya Chieh ; Wu, Pensee ; Li, Kuo Jung ; Yen, Te Hsin ; Shiau, Ai Li ; Wu, Chao Liang. / Prothymosin α overexpression contributes to the development of pulmonary emphysema. In: Nature Communications. 2013 ; Vol. 4.
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