TY - GEN
T1 - Proteotranscriptomics Analysis Reveals Signature Pathways Associated with Colorectal Cancer Progression
T2 - 22nd IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2022
AU - Lim, Hendrick Gao Min
AU - Fann, Yang C.
AU - Lee, Yuan Chii Gladys
N1 - Publisher Copyright:
© 2022 IEEE.
PY - 2022
Y1 - 2022
N2 - Colorectal cancer is one of the most common cancers in hnmans. Studying proteotranscriptomics data conld be essential to discovering signature pathways in colorectal cancer progression. Herein, we conducted a proteotranscriptomics analysis to identify pathway differences of cancer progression at the transcript and protein levels, each of which was represented by an independent colorectal cancer study containing tumor and adjacent normal samples. As a result, additional information on pathways at the protein level showed signature pathways associated with colorectal cancer progression which might not have been revealed at the transcript level. Information on the focal adhesion pathway related to actin cytoskeletal regulation and cancer pathways was preserved only at the protein level. Meanwhile, an oxidative phosphorylation pathway, that was highly correlated with the neurodegenerative Alzheimer, Huntington, and Parkinson diseases, was preserved at both the transcript and protein levels. This pilot study also suggests that both focal adhesion and oxidative phosphorylation could be potential colorectal cancer therapeutic targets.
AB - Colorectal cancer is one of the most common cancers in hnmans. Studying proteotranscriptomics data conld be essential to discovering signature pathways in colorectal cancer progression. Herein, we conducted a proteotranscriptomics analysis to identify pathway differences of cancer progression at the transcript and protein levels, each of which was represented by an independent colorectal cancer study containing tumor and adjacent normal samples. As a result, additional information on pathways at the protein level showed signature pathways associated with colorectal cancer progression which might not have been revealed at the transcript level. Information on the focal adhesion pathway related to actin cytoskeletal regulation and cancer pathways was preserved only at the protein level. Meanwhile, an oxidative phosphorylation pathway, that was highly correlated with the neurodegenerative Alzheimer, Huntington, and Parkinson diseases, was preserved at both the transcript and protein levels. This pilot study also suggests that both focal adhesion and oxidative phosphorylation could be potential colorectal cancer therapeutic targets.
KW - biological pathways
KW - colorectal cancer
KW - focal adhesion
KW - glycolysis
KW - oxidative phosphorylation
KW - proteotranscriptomics
KW - Warburg effect
UR - http://www.scopus.com/inward/record.url?scp=85145560244&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85145560244&partnerID=8YFLogxK
U2 - 10.1109/BIBE55377.2022.00055
DO - 10.1109/BIBE55377.2022.00055
M3 - Conference contribution
AN - SCOPUS:85145560244
T3 - Proceedings - IEEE 22nd International Conference on Bioinformatics and Bioengineering, BIBE 2022
SP - 225
EP - 230
BT - Proceedings - IEEE 22nd International Conference on Bioinformatics and Bioengineering, BIBE 2022
PB - Institute of Electrical and Electronics Engineers Inc.
Y2 - 7 November 2022 through 9 November 2022
ER -
