Proteoglycan Endocan: A multifaceted therapeutic target in Cancer

Ke Fan Pan; Yi Chieh Yang; Wei Jiunn Lee; Kuo Tai Hua; Ming Hsien Chien

doi:10.1016/j.bbcan.2021.188672

Proteoglycan Endocan: A multifaceted therapeutic target in Cancer

Ke Fan Pan, Yi Chieh Yang, Wei Jiunn Lee, Kuo Tai Hua, Ming Hsien Chien

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

Endocan is known to be a circulating dermatan sulfate proteoglycan that regulates endothelial cell function. Dysregulation of endocan expression is observed not only in the tumor vasculature but also in cancer cells. Accumulating evidence has revealed that disordered endocan facilitates cancer progression via enhancing cancer cell proliferation, cell mobility, and cancer stemness properties. Recently, various interacting proteins and diverse subcellular localizations of endocan were identified in cancer cells. Herein, we summarize the application of endocan in cancer diagnoses and prognoses using serum and tumor specimens. We further discuss that the aberrant molecular characteristics of endocan may be due to the mislocalization of endocan in cancer cells. Defining the specific cellular roles of endocan will provide a promising diagnostic factor and therapeutic target for cancer patients.

Original language	English
Article number	188672
Journal	Biochimica et Biophysica Acta - Reviews on Cancer
Volume	1877
Issue number	1
DOIs	https://doi.org/10.1016/j.bbcan.2021.188672
Publication status	Published - Jan 2022

Keywords

Cancer diagnosis
Cancer prognosis
Endocan
Mislocalization
Targeted therapy

ASJC Scopus subject areas

Oncology
Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbcan.2021.188672

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title = "Proteoglycan Endocan: A multifaceted therapeutic target in Cancer",

abstract = "Endocan is known to be a circulating dermatan sulfate proteoglycan that regulates endothelial cell function. Dysregulation of endocan expression is observed not only in the tumor vasculature but also in cancer cells. Accumulating evidence has revealed that disordered endocan facilitates cancer progression via enhancing cancer cell proliferation, cell mobility, and cancer stemness properties. Recently, various interacting proteins and diverse subcellular localizations of endocan were identified in cancer cells. Herein, we summarize the application of endocan in cancer diagnoses and prognoses using serum and tumor specimens. We further discuss that the aberrant molecular characteristics of endocan may be due to the mislocalization of endocan in cancer cells. Defining the specific cellular roles of endocan will provide a promising diagnostic factor and therapeutic target for cancer patients.",

keywords = "Cancer diagnosis, Cancer prognosis, Endocan, Mislocalization, Targeted therapy",

author = "Pan, {Ke Fan} and Yang, {Yi Chieh} and Lee, {Wei Jiunn} and Hua, {Kuo Tai} and Chien, {Ming Hsien}",

note = "Funding Information: This work was supported by grants from the Ministry of Sciences and Technology, Taiwan ( 110-2628-B-002-062 , 109-2320-B-038-052-MY3 , and 107-2320-B-038-022-MY3 ). This work was also supported by the TMU Research Center of Cancer Translational Medicine from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan. Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2022",

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doi = "10.1016/j.bbcan.2021.188672",

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AU - Pan, Ke Fan

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AU - Lee, Wei Jiunn

AU - Hua, Kuo Tai

AU - Chien, Ming Hsien

N1 - Funding Information: This work was supported by grants from the Ministry of Sciences and Technology, Taiwan ( 110-2628-B-002-062 , 109-2320-B-038-052-MY3 , and 107-2320-B-038-022-MY3 ). This work was also supported by the TMU Research Center of Cancer Translational Medicine from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan. Publisher Copyright: © 2021 Elsevier B.V.

PY - 2022/1

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N2 - Endocan is known to be a circulating dermatan sulfate proteoglycan that regulates endothelial cell function. Dysregulation of endocan expression is observed not only in the tumor vasculature but also in cancer cells. Accumulating evidence has revealed that disordered endocan facilitates cancer progression via enhancing cancer cell proliferation, cell mobility, and cancer stemness properties. Recently, various interacting proteins and diverse subcellular localizations of endocan were identified in cancer cells. Herein, we summarize the application of endocan in cancer diagnoses and prognoses using serum and tumor specimens. We further discuss that the aberrant molecular characteristics of endocan may be due to the mislocalization of endocan in cancer cells. Defining the specific cellular roles of endocan will provide a promising diagnostic factor and therapeutic target for cancer patients.

AB - Endocan is known to be a circulating dermatan sulfate proteoglycan that regulates endothelial cell function. Dysregulation of endocan expression is observed not only in the tumor vasculature but also in cancer cells. Accumulating evidence has revealed that disordered endocan facilitates cancer progression via enhancing cancer cell proliferation, cell mobility, and cancer stemness properties. Recently, various interacting proteins and diverse subcellular localizations of endocan were identified in cancer cells. Herein, we summarize the application of endocan in cancer diagnoses and prognoses using serum and tumor specimens. We further discuss that the aberrant molecular characteristics of endocan may be due to the mislocalization of endocan in cancer cells. Defining the specific cellular roles of endocan will provide a promising diagnostic factor and therapeutic target for cancer patients.

KW - Cancer diagnosis

KW - Cancer prognosis

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KW - Mislocalization

KW - Targeted therapy

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Proteoglycan Endocan: A multifaceted therapeutic target in Cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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