Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression

Yi Ju Chen, Theodoros I. Roumeliotis, Ya Hsuan Chang, Ching Tai Chen, Chia Li Han, Miao Hsia Lin, Huei Wen Chen, Gee Chen Chang, Yih Leong Chang, Chen Tu Wu, Mong Wei Lin, Min Shu Hsieh, Yu Tai Wang, Yet Ran Chen, Inge Jonassen, Fatemeh Zamanzad Ghavidel, Ze Shiang Lin, Kuen Tyng Lin, Ching Wen Chen, Pei Yuan SheuChen Ting Hung, Ke Chieh Huang, Hao Chin Yang, Pei Yi Lin, Ta Chi Yen, Yi Wei Lin, Jen Hung Wang, Lovely Raghav, Chien Yu Lin, Yan Si Chen, Pei Shan Wu, Chi Ting Lai, Shao Hsing Weng, Kang Yi Su, Wei Hung Chang, Pang Yan Tsai, Ana I. Robles, Henry Rodriguez, Yi Jing Hsiao, Wen Hsin Chang, Ting Yi Sung, Jin Shing Chen, Sung Liang Yu, Jyoti S. Choudhary, Hsuan Yu Chen, Pan Chyr Yang, Yu Ju Chen

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Deep proteogenomic landscape of early stage lung adenocarcinoma in a cohort of mostly non-smokers reveals unique drivers and biomarkers, as well as gender-associated mutagenesis.

Original languageEnglish
Pages (from-to)226-244.e17
JournalCell
Volume182
Issue number1
DOIs
Publication statusPublished - Jul 9 2020

Keywords

  • APOBEC signature
  • carcinogen signature
  • genomics
  • lung cancer
  • MMP
  • non-smoker
  • phosphoproteomics
  • proteogenomics
  • proteomics
  • subtyping

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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