Proteinuria and reduced estimated glomerular filtration rate independently predict risk for acute myocardial infarction: Findings from a population-based study in Keelung, Taiwan

Shu Hsuan Chang, Chia Ti Tsai, Amy Ming Fang Yen, Meng Huan Lei, Hsiu Hsi Chen, Chuen Den Tseng

Research output: Contribution to journalArticle

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Abstract

Background: The aim of this study was to evaluate the independent roles of proteinuria and reduced estimated glomerular filtration rate (GFR) in the development of acute myocardial infarction in a northern Taiwanese population. Methods: We conducted a community-based prospective cohort study in Keelung, the northernmost county of Taiwan. A total of 63,129 subjects (63% women) 蠇 20 years of age who had no history of coronary heart disease were recruited and followed-up. Univariate and multivariate proportional hazards regression analysis was performed to assess the association between proteinuria and estimated GFR and the risk of acute myocardial infarction. Results: There were 305 new cases of acute myocardial infarction (114 women and 191 men) documented during a four-year follow-up period. After adjustment of potential confounding covariates, heavier proteinuria (dipstick urinalysis reading 3+) and estimated GFR of less than 60 ml/min/1.73 m2 independently predicted increased risk of developing acute myocardial infarction. The adjusted hazard ratio (aHR) of heavier proteinuria for occurrence of acute myocardial infarction was 1.85 [95% confidence intervals (CI), 1.17-2.91, p <0.01] (vs. the reference group: negative dipstick proteinuria). The aHR of estimated GFR of 30-59 ml/min/1.73 m2 for occurrence of acute myocardial infarction was 2.4 (95% CI, 1.31-4.38, p <0.01) (vs. the reference group: estimated GFR 蠇 90 ml/min/1.73 m2), and that of estimated GFR of 15-29 ml/min/1.73 m2 was 5.26 (95% CI, 2.26-12.26, p <0.01). Conclusions: We demonstrated that both heavier proteinuria and lower estimated GFR are significant independent predictors of developing future acute myocardial infarction in a northern Taiwanese population.

Original languageEnglish
Pages (from-to)106-112
Number of pages7
JournalActa Cardiologica Sinica
Volume31
Issue number2
DOIs
Publication statusPublished - Mar 1 2015

Fingerprint

Glomerular Filtration Rate
Taiwan
Proteinuria
Myocardial Infarction
Population
Confidence Intervals
Urinalysis
Coronary Disease
Reading
Cohort Studies
Regression Analysis
Prospective Studies

Keywords

  • Acute myocardial infarction
  • Estimated glomerular filtration rate
  • Proteinuria

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Proteinuria and reduced estimated glomerular filtration rate independently predict risk for acute myocardial infarction : Findings from a population-based study in Keelung, Taiwan. / Chang, Shu Hsuan; Tsai, Chia Ti; Yen, Amy Ming Fang; Lei, Meng Huan; Chen, Hsiu Hsi; Tseng, Chuen Den.

In: Acta Cardiologica Sinica, Vol. 31, No. 2, 01.03.2015, p. 106-112.

Research output: Contribution to journalArticle

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abstract = "Background: The aim of this study was to evaluate the independent roles of proteinuria and reduced estimated glomerular filtration rate (GFR) in the development of acute myocardial infarction in a northern Taiwanese population. Methods: We conducted a community-based prospective cohort study in Keelung, the northernmost county of Taiwan. A total of 63,129 subjects (63{\%} women) 蠇 20 years of age who had no history of coronary heart disease were recruited and followed-up. Univariate and multivariate proportional hazards regression analysis was performed to assess the association between proteinuria and estimated GFR and the risk of acute myocardial infarction. Results: There were 305 new cases of acute myocardial infarction (114 women and 191 men) documented during a four-year follow-up period. After adjustment of potential confounding covariates, heavier proteinuria (dipstick urinalysis reading 3+) and estimated GFR of less than 60 ml/min/1.73 m2 independently predicted increased risk of developing acute myocardial infarction. The adjusted hazard ratio (aHR) of heavier proteinuria for occurrence of acute myocardial infarction was 1.85 [95{\%} confidence intervals (CI), 1.17-2.91, p <0.01] (vs. the reference group: negative dipstick proteinuria). The aHR of estimated GFR of 30-59 ml/min/1.73 m2 for occurrence of acute myocardial infarction was 2.4 (95{\%} CI, 1.31-4.38, p <0.01) (vs. the reference group: estimated GFR 蠇 90 ml/min/1.73 m2), and that of estimated GFR of 15-29 ml/min/1.73 m2 was 5.26 (95{\%} CI, 2.26-12.26, p <0.01). Conclusions: We demonstrated that both heavier proteinuria and lower estimated GFR are significant independent predictors of developing future acute myocardial infarction in a northern Taiwanese population.",
keywords = "Acute myocardial infarction, Estimated glomerular filtration rate, Proteinuria",
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T1 - Proteinuria and reduced estimated glomerular filtration rate independently predict risk for acute myocardial infarction

T2 - Findings from a population-based study in Keelung, Taiwan

AU - Chang, Shu Hsuan

AU - Tsai, Chia Ti

AU - Yen, Amy Ming Fang

AU - Lei, Meng Huan

AU - Chen, Hsiu Hsi

AU - Tseng, Chuen Den

PY - 2015/3/1

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N2 - Background: The aim of this study was to evaluate the independent roles of proteinuria and reduced estimated glomerular filtration rate (GFR) in the development of acute myocardial infarction in a northern Taiwanese population. Methods: We conducted a community-based prospective cohort study in Keelung, the northernmost county of Taiwan. A total of 63,129 subjects (63% women) 蠇 20 years of age who had no history of coronary heart disease were recruited and followed-up. Univariate and multivariate proportional hazards regression analysis was performed to assess the association between proteinuria and estimated GFR and the risk of acute myocardial infarction. Results: There were 305 new cases of acute myocardial infarction (114 women and 191 men) documented during a four-year follow-up period. After adjustment of potential confounding covariates, heavier proteinuria (dipstick urinalysis reading 3+) and estimated GFR of less than 60 ml/min/1.73 m2 independently predicted increased risk of developing acute myocardial infarction. The adjusted hazard ratio (aHR) of heavier proteinuria for occurrence of acute myocardial infarction was 1.85 [95% confidence intervals (CI), 1.17-2.91, p <0.01] (vs. the reference group: negative dipstick proteinuria). The aHR of estimated GFR of 30-59 ml/min/1.73 m2 for occurrence of acute myocardial infarction was 2.4 (95% CI, 1.31-4.38, p <0.01) (vs. the reference group: estimated GFR 蠇 90 ml/min/1.73 m2), and that of estimated GFR of 15-29 ml/min/1.73 m2 was 5.26 (95% CI, 2.26-12.26, p <0.01). Conclusions: We demonstrated that both heavier proteinuria and lower estimated GFR are significant independent predictors of developing future acute myocardial infarction in a northern Taiwanese population.

AB - Background: The aim of this study was to evaluate the independent roles of proteinuria and reduced estimated glomerular filtration rate (GFR) in the development of acute myocardial infarction in a northern Taiwanese population. Methods: We conducted a community-based prospective cohort study in Keelung, the northernmost county of Taiwan. A total of 63,129 subjects (63% women) 蠇 20 years of age who had no history of coronary heart disease were recruited and followed-up. Univariate and multivariate proportional hazards regression analysis was performed to assess the association between proteinuria and estimated GFR and the risk of acute myocardial infarction. Results: There were 305 new cases of acute myocardial infarction (114 women and 191 men) documented during a four-year follow-up period. After adjustment of potential confounding covariates, heavier proteinuria (dipstick urinalysis reading 3+) and estimated GFR of less than 60 ml/min/1.73 m2 independently predicted increased risk of developing acute myocardial infarction. The adjusted hazard ratio (aHR) of heavier proteinuria for occurrence of acute myocardial infarction was 1.85 [95% confidence intervals (CI), 1.17-2.91, p <0.01] (vs. the reference group: negative dipstick proteinuria). The aHR of estimated GFR of 30-59 ml/min/1.73 m2 for occurrence of acute myocardial infarction was 2.4 (95% CI, 1.31-4.38, p <0.01) (vs. the reference group: estimated GFR 蠇 90 ml/min/1.73 m2), and that of estimated GFR of 15-29 ml/min/1.73 m2 was 5.26 (95% CI, 2.26-12.26, p <0.01). Conclusions: We demonstrated that both heavier proteinuria and lower estimated GFR are significant independent predictors of developing future acute myocardial infarction in a northern Taiwanese population.

KW - Acute myocardial infarction

KW - Estimated glomerular filtration rate

KW - Proteinuria

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