Protective effects of sesamol and ferulic acid on the formation of endogenous trans-arachidonic acid in hAPP J20 mice

B.-Y. Hsu, W.-L. Hung, C.-T. Ho, I.H. Cheng, L.S. Hwang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is characterized by progressive formation of β-amyloid peptide (Aβ) in the brain. Aβ induced oxidative stress may cause cis-. trans isomerization of fatty acids. However, the research on AD rarely discusses the correlation between the formation of endogenous trans fatty acids (TFA) and the progression of AD. Thus, the goal of this research was to study the difference of trans-arachidonic acid (TAA) composition of brain and hippocampus between J20 mice (AD mouse model) and B6 mice (wild type control). Our results showed that the endogenous TAA (8-. trans-C20:4) of brain and hippocampus in 9 months old J20 mice was significantly higher than B6 mice which indicated that there was a positive relationship between the formation of endogenous TAA and AD. In addition, this study also revealed that sesamol and ferulic acid could reduce the formation of 8. -trans-C20:4. Thus, they might be employed as potential functional food ingredients for the prevention of AD. © 2015 Elsevier Ltd.
Original languageEnglish
Pages (from-to)378-385
Number of pages8
JournalJournal of Functional Foods
Volume16
DOIs
Publication statusPublished - 2015
Externally publishedYes

Fingerprint

ferulic acid
Alzheimer disease
arachidonic acid
Arachidonic Acid
protective effect
Alzheimer Disease
mice
Trans Fatty Acids
hippocampus
brain
Hippocampus
Brain
Functional Food
disease models
trans fatty acids
isomerization
amyloid
Research
Amyloid
functional foods

Keywords

  • Alzheimer's disease
  • Cis-trans isomerization
  • Endogenous trans-arachidonic acid
  • Ferulic acid
  • Sesamol
  • Mus

Cite this

Protective effects of sesamol and ferulic acid on the formation of endogenous trans-arachidonic acid in hAPP J20 mice. / Hsu, B.-Y.; Hung, W.-L.; Ho, C.-T.; Cheng, I.H.; Hwang, L.S.

In: Journal of Functional Foods, Vol. 16, 2015, p. 378-385.

Research output: Contribution to journalArticle

@article{a0b6f505740d47dcaa42394e4510370f,
title = "Protective effects of sesamol and ferulic acid on the formation of endogenous trans-arachidonic acid in hAPP J20 mice",
abstract = "Alzheimer's disease (AD) is characterized by progressive formation of β-amyloid peptide (Aβ) in the brain. Aβ induced oxidative stress may cause cis-. trans isomerization of fatty acids. However, the research on AD rarely discusses the correlation between the formation of endogenous trans fatty acids (TFA) and the progression of AD. Thus, the goal of this research was to study the difference of trans-arachidonic acid (TAA) composition of brain and hippocampus between J20 mice (AD mouse model) and B6 mice (wild type control). Our results showed that the endogenous TAA (8-. trans-C20:4) of brain and hippocampus in 9 months old J20 mice was significantly higher than B6 mice which indicated that there was a positive relationship between the formation of endogenous TAA and AD. In addition, this study also revealed that sesamol and ferulic acid could reduce the formation of 8. -trans-C20:4. Thus, they might be employed as potential functional food ingredients for the prevention of AD. {\circledC} 2015 Elsevier Ltd.",
keywords = "Alzheimer's disease, Cis-trans isomerization, Endogenous trans-arachidonic acid, Ferulic acid, Sesamol, Mus",
author = "B.-Y. Hsu and W.-L. Hung and C.-T. Ho and I.H. Cheng and L.S. Hwang",
note = "引用次數:3 Export Date: 19 September 2018 通訊地址: Hwang, L.S.; Graduate Institute of Food Science and Technology, National Taiwan University, No.1, Sec. 4, Roosevelt Road, Taiwan; 電子郵件: lshwang@ntu.edu.tw 出資詳情: MOST, Ministry of Science and Technology, Taiwan 出資詳情: 99-2628-B-002-015-MY3 出資正文: This study was supported by a research grant, NSC 99-2628-B-002-015-MY3 , from the Ministry of Science and Technology , Taiwan. 參考文獻: Areosa, S.A., Sherriff, F., Memantine for dementia (2006) Cochrane Database Systematic Reviews, (3); Balazy, M., Trans-arachidonic acids: New mediators of inflammation (2000) Journal of Physiology and Pharmacology, 51, pp. 597-607; Balazy, M., Chemtob, S., Trans-arachidonic acids: New mediators of nitro-oxidative stress (2008) Pharmacology Therapeutics, 119, pp. 275-290; Balazy, M., Poff, C.D., Biological nitration of arachidonic acid (2004) Current Vascular Pharmacology, 2, pp. 81-93; Benchekroun, M., Ismaili, L., Pudlo, M., Luzet, V., Gharbi, T., Refouvelet, B., Marco-Contelles, J., Donepezil-ferulic acid hybrids as anti-Alzheimer drugs (2015) Future Medicinal Chemistry, 7 (1), pp. 15-21; Butterfield, D.A., Castegna, A., Pocernich, C.B., Drake, J., Scapagnini, G., Calabrese, V., Nutritional approaches to combat oxidative stress in Alzheimer's disease (2002) Journal of Nutritional Biochemistry, 13, pp. 444-461; Chen, Y., Sun, J., Fang, L., Liu, M., Peng, S., Liao, H., Lehmann, J., Zhang, Y., Tacrine-ferulic acid-nitric oxide (NO) donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors (2012) Journal of Medicinal Chemistry, 55, pp. 4309-4321; Fang, L., Kraus, B., Lehmann, J., Heilmann, J., Zhang, Y., Decker, M., Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates (2008) Bioorganic & Medicinal Chemistry Letters, 18, pp. 2905-2909; Ferreri, C., Panagiotaki, M., Chatgilialoglu, C., Trans fatty acids in membranes: the free radical path (2007) Molecular Biotechnology, 37, pp. 19-25; Folch, J., Lees, M., Stanley, G.H.S., A simple method for the isolation and purification of total lipids from animal tissues (1957) The Journal of Biological Chemistry, 226, pp. 497-509; Fuentes, E., Palomo, I., Antiplatelet effect of natural bioactive compounds by multiple targets: Food and drug interaction (2014) Journal of Functional Foods, 6, pp. 73-84; Glass, C.K., Saijo, K., Winner, B., Marchetto, M.C., Gage, F.H., Mechanisms underlying inflammation in neurodegeneration (2010) Cell, 140, pp. 918-934; Hauff, S., Vetter, W., Quantitation of cis- and trans-monounsaturated fatty acids in dairy products and cod liver oil by mass spectrometry in the selected ion monitoring mode (2009) Journal of Agricultural and Food Chemistry, 57, pp. 3423-3430; Hou, R.C.W., Chen, Y.S., Chen, C.H., Chen, Y.H., Jeng, K.C.G., Protective effect of 1,2,4-benzenetriol on LPS-induced NO production by BV2 microglial cells (2006) Journal of Biomedical Science, 13, pp. 89-99; Hung, W.L., Ho, C.T., Hwang, S.L., Inhibitory activity of natural occurring antioxidants on thiyl radical-induced trans-arachidonic acid formation (2011) Journal of Agricultural and Food Chemistry, 59, pp. 1968-1973; Jiang, H., Kruger, N., Lahiri, D.R., Wang, D., Vat{\`e}le, J.M., Balazy, M., Nitrogen dioxide induces cis-trans-isomerization of arachidonic acid within cellular phospholipids. Detection of trans-arachidonic acids in vivo (1999) The Journal of Biological Chemistry, 274, pp. 16235-16241; Klein, E., Weber, N., In vitro test for the effectiveness of antioxidants as inhibitors of thiyl radical-induced reactions with unsaturated fatty acids (2001) Journal of Agricultural and Food Chemistry, 49, pp. 1224-1227; Lan, W.A., (2010) Analysis of endogenous trans-fatty acids in different tissues of beta amyloid peptide induced Alzheimer's disease Sprague-Dawley rats, , Master Thesis, Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan; Mancuso, C., Siciliano, R., Barone, E., Preziosi, P., Natural substances and Alzheimer's disease: From preclinical studies to evidence based medicine (2012) Biochimica et Biophysica Acta, 1822, pp. 616-624; Martin, C.A., Milinsk, M.C., Visentainer, J.V., Matsushita, M., de-Souza, N.E., Trans fatty acid-forming processes in foods: A review (2007) Anais Da Academia Brasileira de Ciencias, 79, pp. 343-350; Mayeux, R., Early Alzheimer's disease (2010) The New England Journal of Medicine, 362, pp. 2194-2201; Misra, S., Tiwari, V., Kuhad, A., Chopra, K., Modulation of nitrergic pathway by sesamol prevents cognitive deficits and associated biochemical alterations in intracerebroventricular streptozotocin administered rats (2011) European Journal of Pharmacology, 659, pp. 177-186; Morrow, J.D., Roberts, L.J., The isoprostanes: Unique bioactive products of lipid peroxidation (1997) Progress in Lipid Research, 36, pp. 1-21; Mozaffarian, D., Katan, M.B., Ascherio, A., Stampfer, M.J., Willett, W.C., Trans fatty acids and cardiovascular disease (2006) The New England Journal of Medicine, 354, pp. 1601-1613; Mucke, L., Masliah, E., Yu, G.Q., Mallory, M., Rockenstein, E.M., Tatsuno, G., Hu, K., McConlogue, L., High-level neuronal expression of a beta 1-42 in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation (2000) The Journal of Neuroscience, 20, pp. 4050-4058; Narasimhan, R., Vaithiyanathan, M., Janardanam, V., Neuroprotective effect of sesamol in glioma induced in rats (2011) Biomedicine International, 2, pp. 22-27; Ou, S., Kwok, K.C., Ferulic acid: Pharmaceutical functions, preparation and applications in foods (2004) Journal of the Science of Food and Agriculture, 84, pp. 1261-1269; Ou, S., Li, Y., Gao, K., A study on scavenging activity of wheat bran dietary fiber for free radical (1999) Acta Nutrimenta Sinica, 21, pp. 191-194; Pi, R., Mao, X., Chao, X., Cheng, Z., Liu, M., Duan, X., Ye, M., Han, Y., Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo (2012) PLoS ONE, 7 (2), pp. 1-8; Prasad, N.R., Mahesh, T., Menon, V.P., Jeevanram, R.K., Pugalendi, K.V., Photoprotective effect of sesamol on UVB-radiation induced oxidative stress in human blood lymphocytes in vitro (2005) Environmental Toxicology and Pharmacology, 20, pp. 1-5; Roach, C., Feller, S.E., Ward, J.A., Shaikh, S.R., Zerouga, M., Stillwell, W., Comparison of cis and trans fatty acid containing phosphatidylcholines on membrane properties (2004) Biochemistry, 43, pp. 6344-6351; Shahidi, F., Zhong, Y., Measurement of antioxidant activity (2015) Journal of Functional Foods; Shahwar, D., Rehman, S.U., Raza, M.A., Acetyl cholinesterase inhibition potential and antioxidant activities of ferulic acid isolated from Impatiens bicolor Linn (2010) Journal of Medicinal Plants Research, 4 (3), pp. 260-266; Sharma, S., Kaur, I.P., Development and evaluation of sesamol as an antiaging agent (2006) International Journal of Dermatology, 45, pp. 200-208; Slattery, M.L., Benson, J., Ma, K.N., Schaffer, D., Potter, J.D., Trans fatty acids and colon cancer (2001) Nutrition and Cancer, 39, pp. 170-175; Szwajgier, D., Borowiec, K., Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors (2012) Journal of the Institute of Brewing, 118, pp. 40-48; Wu, T.Y., Chen, C.P., Jinn, T.R., Traditional Chinese medicines and Alzheimer's disease (2011) Taiwanese Journal of Obstetrics & Gynecology, 50, pp. 131-135; Yan, J.J., Cho, J.Y., Kim, H.S., Kim, K.L., Jung, J.S., Huh, S.O., Suh, H.W., Song, D.K., Protection against β-amyloid peptide toxicity in vivo with long-term administration of ferulic acid (2001) British Journal of Pharmacology, 133, pp. 89-96; Yan, J.J., Jung, J.S., Kim, T.K., Hasan, M.A., Hong, C.W., Nam, J.S., Song, D.K., Protective effects of ferulic acid in amyloid precursor protein plus presenilin-1 transgenic mouse model of Alzheimer disease (2013) Biological and Pharmaceutical Bulletin, 36 (1), pp. 140-143; Zambonin, L., Ferreri, C., Cabrini, L., Prata, C., Chatgilialoglu, C., Landi, L., Occurrence of trans fatty acids in rats fed a trans-free diet: A free radical-mediated formation? (2006) Free Radical Biology and Medicine, 40, pp. 1549-1556; Zambonin, L., Prata, C., Cabrini, L., Maraldi, T., Fiorentini, D., Vieceli, D., Sega, F., Landi, L., Effect of radical stress and ageing on the occurrence of trans fatty acids in rats fed a trans-free diet (2008) Free Radical Biology and Medicine, 44, pp. 594-601; Zhang, Z.E., Yao, S.D., Lin, W.Z., Wang, W.F., Jin, Y.Z., Lin, N.Y., Mechanism of reaction of nitrogen dioxide radical with hydroxycinnamic acid derivatives: A pulse radiolysis study (1998) Free Radical Research, 29, pp. 13-16",
year = "2015",
doi = "10.1016/j.jff.2015.04.035",
language = "English",
volume = "16",
pages = "378--385",
journal = "Journal of Functional Foods",
issn = "1756-4646",
publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Protective effects of sesamol and ferulic acid on the formation of endogenous trans-arachidonic acid in hAPP J20 mice

AU - Hsu, B.-Y.

AU - Hung, W.-L.

AU - Ho, C.-T.

AU - Cheng, I.H.

AU - Hwang, L.S.

N1 - 引用次數:3 Export Date: 19 September 2018 通訊地址: Hwang, L.S.; Graduate Institute of Food Science and Technology, National Taiwan University, No.1, Sec. 4, Roosevelt Road, Taiwan; 電子郵件: lshwang@ntu.edu.tw 出資詳情: MOST, Ministry of Science and Technology, Taiwan 出資詳情: 99-2628-B-002-015-MY3 出資正文: This study was supported by a research grant, NSC 99-2628-B-002-015-MY3 , from the Ministry of Science and Technology , Taiwan. 參考文獻: Areosa, S.A., Sherriff, F., Memantine for dementia (2006) Cochrane Database Systematic Reviews, (3); Balazy, M., Trans-arachidonic acids: New mediators of inflammation (2000) Journal of Physiology and Pharmacology, 51, pp. 597-607; Balazy, M., Chemtob, S., Trans-arachidonic acids: New mediators of nitro-oxidative stress (2008) Pharmacology Therapeutics, 119, pp. 275-290; Balazy, M., Poff, C.D., Biological nitration of arachidonic acid (2004) Current Vascular Pharmacology, 2, pp. 81-93; Benchekroun, M., Ismaili, L., Pudlo, M., Luzet, V., Gharbi, T., Refouvelet, B., Marco-Contelles, J., Donepezil-ferulic acid hybrids as anti-Alzheimer drugs (2015) Future Medicinal Chemistry, 7 (1), pp. 15-21; Butterfield, D.A., Castegna, A., Pocernich, C.B., Drake, J., Scapagnini, G., Calabrese, V., Nutritional approaches to combat oxidative stress in Alzheimer's disease (2002) Journal of Nutritional Biochemistry, 13, pp. 444-461; Chen, Y., Sun, J., Fang, L., Liu, M., Peng, S., Liao, H., Lehmann, J., Zhang, Y., Tacrine-ferulic acid-nitric oxide (NO) donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors (2012) Journal of Medicinal Chemistry, 55, pp. 4309-4321; Fang, L., Kraus, B., Lehmann, J., Heilmann, J., Zhang, Y., Decker, M., Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates (2008) Bioorganic & Medicinal Chemistry Letters, 18, pp. 2905-2909; Ferreri, C., Panagiotaki, M., Chatgilialoglu, C., Trans fatty acids in membranes: the free radical path (2007) Molecular Biotechnology, 37, pp. 19-25; Folch, J., Lees, M., Stanley, G.H.S., A simple method for the isolation and purification of total lipids from animal tissues (1957) The Journal of Biological Chemistry, 226, pp. 497-509; Fuentes, E., Palomo, I., Antiplatelet effect of natural bioactive compounds by multiple targets: Food and drug interaction (2014) Journal of Functional Foods, 6, pp. 73-84; Glass, C.K., Saijo, K., Winner, B., Marchetto, M.C., Gage, F.H., Mechanisms underlying inflammation in neurodegeneration (2010) Cell, 140, pp. 918-934; Hauff, S., Vetter, W., Quantitation of cis- and trans-monounsaturated fatty acids in dairy products and cod liver oil by mass spectrometry in the selected ion monitoring mode (2009) Journal of Agricultural and Food Chemistry, 57, pp. 3423-3430; Hou, R.C.W., Chen, Y.S., Chen, C.H., Chen, Y.H., Jeng, K.C.G., Protective effect of 1,2,4-benzenetriol on LPS-induced NO production by BV2 microglial cells (2006) Journal of Biomedical Science, 13, pp. 89-99; Hung, W.L., Ho, C.T., Hwang, S.L., Inhibitory activity of natural occurring antioxidants on thiyl radical-induced trans-arachidonic acid formation (2011) Journal of Agricultural and Food Chemistry, 59, pp. 1968-1973; Jiang, H., Kruger, N., Lahiri, D.R., Wang, D., Vatèle, J.M., Balazy, M., Nitrogen dioxide induces cis-trans-isomerization of arachidonic acid within cellular phospholipids. Detection of trans-arachidonic acids in vivo (1999) The Journal of Biological Chemistry, 274, pp. 16235-16241; Klein, E., Weber, N., In vitro test for the effectiveness of antioxidants as inhibitors of thiyl radical-induced reactions with unsaturated fatty acids (2001) Journal of Agricultural and Food Chemistry, 49, pp. 1224-1227; Lan, W.A., (2010) Analysis of endogenous trans-fatty acids in different tissues of beta amyloid peptide induced Alzheimer's disease Sprague-Dawley rats, , Master Thesis, Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan; Mancuso, C., Siciliano, R., Barone, E., Preziosi, P., Natural substances and Alzheimer's disease: From preclinical studies to evidence based medicine (2012) Biochimica et Biophysica Acta, 1822, pp. 616-624; Martin, C.A., Milinsk, M.C., Visentainer, J.V., Matsushita, M., de-Souza, N.E., Trans fatty acid-forming processes in foods: A review (2007) Anais Da Academia Brasileira de Ciencias, 79, pp. 343-350; Mayeux, R., Early Alzheimer's disease (2010) The New England Journal of Medicine, 362, pp. 2194-2201; Misra, S., Tiwari, V., Kuhad, A., Chopra, K., Modulation of nitrergic pathway by sesamol prevents cognitive deficits and associated biochemical alterations in intracerebroventricular streptozotocin administered rats (2011) European Journal of Pharmacology, 659, pp. 177-186; Morrow, J.D., Roberts, L.J., The isoprostanes: Unique bioactive products of lipid peroxidation (1997) Progress in Lipid Research, 36, pp. 1-21; Mozaffarian, D., Katan, M.B., Ascherio, A., Stampfer, M.J., Willett, W.C., Trans fatty acids and cardiovascular disease (2006) The New England Journal of Medicine, 354, pp. 1601-1613; Mucke, L., Masliah, E., Yu, G.Q., Mallory, M., Rockenstein, E.M., Tatsuno, G., Hu, K., McConlogue, L., High-level neuronal expression of a beta 1-42 in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation (2000) The Journal of Neuroscience, 20, pp. 4050-4058; Narasimhan, R., Vaithiyanathan, M., Janardanam, V., Neuroprotective effect of sesamol in glioma induced in rats (2011) Biomedicine International, 2, pp. 22-27; Ou, S., Kwok, K.C., Ferulic acid: Pharmaceutical functions, preparation and applications in foods (2004) Journal of the Science of Food and Agriculture, 84, pp. 1261-1269; Ou, S., Li, Y., Gao, K., A study on scavenging activity of wheat bran dietary fiber for free radical (1999) Acta Nutrimenta Sinica, 21, pp. 191-194; Pi, R., Mao, X., Chao, X., Cheng, Z., Liu, M., Duan, X., Ye, M., Han, Y., Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo (2012) PLoS ONE, 7 (2), pp. 1-8; Prasad, N.R., Mahesh, T., Menon, V.P., Jeevanram, R.K., Pugalendi, K.V., Photoprotective effect of sesamol on UVB-radiation induced oxidative stress in human blood lymphocytes in vitro (2005) Environmental Toxicology and Pharmacology, 20, pp. 1-5; Roach, C., Feller, S.E., Ward, J.A., Shaikh, S.R., Zerouga, M., Stillwell, W., Comparison of cis and trans fatty acid containing phosphatidylcholines on membrane properties (2004) Biochemistry, 43, pp. 6344-6351; Shahidi, F., Zhong, Y., Measurement of antioxidant activity (2015) Journal of Functional Foods; Shahwar, D., Rehman, S.U., Raza, M.A., Acetyl cholinesterase inhibition potential and antioxidant activities of ferulic acid isolated from Impatiens bicolor Linn (2010) Journal of Medicinal Plants Research, 4 (3), pp. 260-266; Sharma, S., Kaur, I.P., Development and evaluation of sesamol as an antiaging agent (2006) International Journal of Dermatology, 45, pp. 200-208; Slattery, M.L., Benson, J., Ma, K.N., Schaffer, D., Potter, J.D., Trans fatty acids and colon cancer (2001) Nutrition and Cancer, 39, pp. 170-175; Szwajgier, D., Borowiec, K., Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors (2012) Journal of the Institute of Brewing, 118, pp. 40-48; Wu, T.Y., Chen, C.P., Jinn, T.R., Traditional Chinese medicines and Alzheimer's disease (2011) Taiwanese Journal of Obstetrics & Gynecology, 50, pp. 131-135; Yan, J.J., Cho, J.Y., Kim, H.S., Kim, K.L., Jung, J.S., Huh, S.O., Suh, H.W., Song, D.K., Protection against β-amyloid peptide toxicity in vivo with long-term administration of ferulic acid (2001) British Journal of Pharmacology, 133, pp. 89-96; Yan, J.J., Jung, J.S., Kim, T.K., Hasan, M.A., Hong, C.W., Nam, J.S., Song, D.K., Protective effects of ferulic acid in amyloid precursor protein plus presenilin-1 transgenic mouse model of Alzheimer disease (2013) Biological and Pharmaceutical Bulletin, 36 (1), pp. 140-143; Zambonin, L., Ferreri, C., Cabrini, L., Prata, C., Chatgilialoglu, C., Landi, L., Occurrence of trans fatty acids in rats fed a trans-free diet: A free radical-mediated formation? (2006) Free Radical Biology and Medicine, 40, pp. 1549-1556; Zambonin, L., Prata, C., Cabrini, L., Maraldi, T., Fiorentini, D., Vieceli, D., Sega, F., Landi, L., Effect of radical stress and ageing on the occurrence of trans fatty acids in rats fed a trans-free diet (2008) Free Radical Biology and Medicine, 44, pp. 594-601; Zhang, Z.E., Yao, S.D., Lin, W.Z., Wang, W.F., Jin, Y.Z., Lin, N.Y., Mechanism of reaction of nitrogen dioxide radical with hydroxycinnamic acid derivatives: A pulse radiolysis study (1998) Free Radical Research, 29, pp. 13-16

PY - 2015

Y1 - 2015

N2 - Alzheimer's disease (AD) is characterized by progressive formation of β-amyloid peptide (Aβ) in the brain. Aβ induced oxidative stress may cause cis-. trans isomerization of fatty acids. However, the research on AD rarely discusses the correlation between the formation of endogenous trans fatty acids (TFA) and the progression of AD. Thus, the goal of this research was to study the difference of trans-arachidonic acid (TAA) composition of brain and hippocampus between J20 mice (AD mouse model) and B6 mice (wild type control). Our results showed that the endogenous TAA (8-. trans-C20:4) of brain and hippocampus in 9 months old J20 mice was significantly higher than B6 mice which indicated that there was a positive relationship between the formation of endogenous TAA and AD. In addition, this study also revealed that sesamol and ferulic acid could reduce the formation of 8. -trans-C20:4. Thus, they might be employed as potential functional food ingredients for the prevention of AD. © 2015 Elsevier Ltd.

AB - Alzheimer's disease (AD) is characterized by progressive formation of β-amyloid peptide (Aβ) in the brain. Aβ induced oxidative stress may cause cis-. trans isomerization of fatty acids. However, the research on AD rarely discusses the correlation between the formation of endogenous trans fatty acids (TFA) and the progression of AD. Thus, the goal of this research was to study the difference of trans-arachidonic acid (TAA) composition of brain and hippocampus between J20 mice (AD mouse model) and B6 mice (wild type control). Our results showed that the endogenous TAA (8-. trans-C20:4) of brain and hippocampus in 9 months old J20 mice was significantly higher than B6 mice which indicated that there was a positive relationship between the formation of endogenous TAA and AD. In addition, this study also revealed that sesamol and ferulic acid could reduce the formation of 8. -trans-C20:4. Thus, they might be employed as potential functional food ingredients for the prevention of AD. © 2015 Elsevier Ltd.

KW - Alzheimer's disease

KW - Cis-trans isomerization

KW - Endogenous trans-arachidonic acid

KW - Ferulic acid

KW - Sesamol

KW - Mus

U2 - 10.1016/j.jff.2015.04.035

DO - 10.1016/j.jff.2015.04.035

M3 - Article

VL - 16

SP - 378

EP - 385

JO - Journal of Functional Foods

JF - Journal of Functional Foods

SN - 1756-4646

ER -