Protective effects of resveratrol supplementation on contusion induced muscle injury

Yi Ju Hsu, Chun Shen Ho, Mon Chien Lee, Chin Shan Ho, Chi Chang Huang, Nai Wen Kan

Research output: Contribution to journalArticle

Abstract

Muscle injuries frequently occur in contact sports events. The current treatment options for soft tissue injuries remain suboptimal and often result in delayed or incomplete recovery of damaged muscles. Resveratrol (RES) is a phenolic phytochemical, well-known for its antioxidant and anti-inflammatory properties. The purpose of this study is to evaluate the potential beneficial effects of RES supplementation on inflammation and regeneration in skeletal muscle after a contusion injury, in comparison to a conventional treatment of nonsteroidal anti-inflammatory drugs (NSAID). After one week of acclimation, forty eight-week-old male ICR mice were randomly divided into the five groups (n=8 per group): 1) normal control (NC), 2) mass-drop injury without any treatment (mass-drop injury, MDI), 3) post-injury NSAID treatment (MDI+ 10mg/kg NSAID), 4) post-injury RES supplementation (MDI+ 25mg/kg/day RES) and 5) post-injury treatment with RES and NSAID (MDI + resveratrol+ NSAID). After muscle contusion injury of the left gastrocnemius muscle, RES or NSAID were orally administered post-injury once a day for 7 days. Results showed that the MDI group had significantly higher serum uric acid (UA), CREA (creatinine), LDH (lactic dehydrogenase) and creatine kinase (CK) than the normal control group. Treatment with resveratrol reduced muscle damage as evidenced by the significantly decreased serum levels of UA, CREA, LDH and CK after contusion-induced muscle injuries in mice. In addition, RES and RES + NSAID groups promoted muscle satellite cell regeneration with increase in desmin protein after injury. Our results suggest that resveratrol combined with NSAID potentially improve muscle recovery and may be a potential candidate for further development as an effective clinical treatment for muscle repair.

Original languageEnglish
Pages (from-to)53-62
Number of pages10
JournalInternational Journal of Medical Sciences
Volume17
Issue number1
DOIs
Publication statusPublished - Jan 1 2020

Fingerprint

Contusions
Muscles
Wounds and Injuries
Anti-Inflammatory Agents
Pharmaceutical Preparations
resveratrol
Creatine Kinase
Uric Acid
Regeneration
Creatinine
Oxidoreductases
Milk
Skeletal Muscle
Soft Tissue Injuries
Inbred ICR Mouse
Desmin
Acclimatization
Phytochemicals
Serum
Muscle Cells

Keywords

  • CK
  • LDH
  • Mass-drop injury
  • NSAID
  • Regeneration

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Protective effects of resveratrol supplementation on contusion induced muscle injury. / Hsu, Yi Ju; Ho, Chun Shen; Lee, Mon Chien; Ho, Chin Shan; Huang, Chi Chang; Kan, Nai Wen.

In: International Journal of Medical Sciences, Vol. 17, No. 1, 01.01.2020, p. 53-62.

Research output: Contribution to journalArticle

Hsu, Yi Ju ; Ho, Chun Shen ; Lee, Mon Chien ; Ho, Chin Shan ; Huang, Chi Chang ; Kan, Nai Wen. / Protective effects of resveratrol supplementation on contusion induced muscle injury. In: International Journal of Medical Sciences. 2020 ; Vol. 17, No. 1. pp. 53-62.
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