Protective effects of plasma alpha-tocopherols on the risk of inorganic arsenic-related urothelial carcinoma

Chi Jung Chung, Yeong Shiau Pu, Ying Ting Chen, Chien Tien Su, Chia Chang Wu, Horng Sheng Shiue, Chao Yuan Huang, Yu Mei Hsueh

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Arsenic plays an important role in producing oxidative stress in cultured cells. To investigate the interaction between high oxidative stress and low arsenic methylation capacity on arsenic carcinogenesis, a case-control study was conducted to evaluate the relationship among the indices of oxidative stress, such as urinary 8-hydroxydeoxyquanine (8-OHdG), as well as plasma micronutrients and urinary arsenic profiles on urothelial carcinoma (UC) risk. Urinary 8-OHdG was measured using high-sensitivity enzyme-linked immunosorbent assay kits. The urinary arsenic species were analyzed using high-performance liquid chromatography and hydride generator-atomic absorption spectrometry. Plasma micronutrient levels were analyzed using reversed-phase high-performance liquid chromatography. The present study showed a significant protective effect of plasma alpha-tocopherol on UC risk. Plasma alpha-tocopherol levels were significantly inversely related to urinary total arsenic concentrations and inorganic arsenic percentage (InAs%), and significantly positively related to dimethylarsinic acid percentage (DMA%). There were no correlations between plasma micronutrients and urinary 8-OHdG. Study participants with lower alpha-tocopherol and higher urinary total arsenic, higher InAs%, higher MMA%, and lower DMA% had a higher UC risk than those with higher alpha-tocopherol and lower urinary total arsenic, lower InAs%, lower MMA%, and higher DMA%. These results suggest that plasma alpha-tocopherol might modify the risk of inorganic arsenic-related UC.

Original languageEnglish
Pages (from-to)1039-1045
Number of pages7
JournalScience of the Total Environment
Volume409
Issue number6
DOIs
Publication statusPublished - Feb 15 2011

Fingerprint

alpha-Tocopherol
Arsenic
arsenic
Plasmas
plasma
Cacodylic Acid
Oxidative stress
Micronutrients
High performance liquid chromatography
trace element
Acids
liquid chromatography
acid
effect
Immunosorbents
Atomic absorption spectrometry
Methylation
methylation
Hydrides
spectrometry

Keywords

  • 8-OHdG
  • Plasma micronutrients
  • Urinary arsenic profiles
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Environmental Chemistry
  • Pollution
  • Waste Management and Disposal
  • Environmental Engineering

Cite this

Protective effects of plasma alpha-tocopherols on the risk of inorganic arsenic-related urothelial carcinoma. / Chung, Chi Jung; Pu, Yeong Shiau; Chen, Ying Ting; Su, Chien Tien; Wu, Chia Chang; Shiue, Horng Sheng; Huang, Chao Yuan; Hsueh, Yu Mei.

In: Science of the Total Environment, Vol. 409, No. 6, 15.02.2011, p. 1039-1045.

Research output: Contribution to journalArticle

Chung, Chi Jung ; Pu, Yeong Shiau ; Chen, Ying Ting ; Su, Chien Tien ; Wu, Chia Chang ; Shiue, Horng Sheng ; Huang, Chao Yuan ; Hsueh, Yu Mei. / Protective effects of plasma alpha-tocopherols on the risk of inorganic arsenic-related urothelial carcinoma. In: Science of the Total Environment. 2011 ; Vol. 409, No. 6. pp. 1039-1045.
@article{a83251ec7c7543aea48e17237af9baa1,
title = "Protective effects of plasma alpha-tocopherols on the risk of inorganic arsenic-related urothelial carcinoma",
abstract = "Arsenic plays an important role in producing oxidative stress in cultured cells. To investigate the interaction between high oxidative stress and low arsenic methylation capacity on arsenic carcinogenesis, a case-control study was conducted to evaluate the relationship among the indices of oxidative stress, such as urinary 8-hydroxydeoxyquanine (8-OHdG), as well as plasma micronutrients and urinary arsenic profiles on urothelial carcinoma (UC) risk. Urinary 8-OHdG was measured using high-sensitivity enzyme-linked immunosorbent assay kits. The urinary arsenic species were analyzed using high-performance liquid chromatography and hydride generator-atomic absorption spectrometry. Plasma micronutrient levels were analyzed using reversed-phase high-performance liquid chromatography. The present study showed a significant protective effect of plasma alpha-tocopherol on UC risk. Plasma alpha-tocopherol levels were significantly inversely related to urinary total arsenic concentrations and inorganic arsenic percentage (InAs{\%}), and significantly positively related to dimethylarsinic acid percentage (DMA{\%}). There were no correlations between plasma micronutrients and urinary 8-OHdG. Study participants with lower alpha-tocopherol and higher urinary total arsenic, higher InAs{\%}, higher MMA{\%}, and lower DMA{\%} had a higher UC risk than those with higher alpha-tocopherol and lower urinary total arsenic, lower InAs{\%}, lower MMA{\%}, and higher DMA{\%}. These results suggest that plasma alpha-tocopherol might modify the risk of inorganic arsenic-related UC.",
keywords = "8-OHdG, Plasma micronutrients, Urinary arsenic profiles, Urothelial carcinoma",
author = "Chung, {Chi Jung} and Pu, {Yeong Shiau} and Chen, {Ying Ting} and Su, {Chien Tien} and Wu, {Chia Chang} and Shiue, {Horng Sheng} and Huang, {Chao Yuan} and Hsueh, {Yu Mei}",
year = "2011",
month = "2",
day = "15",
doi = "10.1016/j.scitotenv.2010.11.037",
language = "English",
volume = "409",
pages = "1039--1045",
journal = "Science of the Total Environment",
issn = "0048-9697",
publisher = "Elsevier",
number = "6",

}

TY - JOUR

T1 - Protective effects of plasma alpha-tocopherols on the risk of inorganic arsenic-related urothelial carcinoma

AU - Chung, Chi Jung

AU - Pu, Yeong Shiau

AU - Chen, Ying Ting

AU - Su, Chien Tien

AU - Wu, Chia Chang

AU - Shiue, Horng Sheng

AU - Huang, Chao Yuan

AU - Hsueh, Yu Mei

PY - 2011/2/15

Y1 - 2011/2/15

N2 - Arsenic plays an important role in producing oxidative stress in cultured cells. To investigate the interaction between high oxidative stress and low arsenic methylation capacity on arsenic carcinogenesis, a case-control study was conducted to evaluate the relationship among the indices of oxidative stress, such as urinary 8-hydroxydeoxyquanine (8-OHdG), as well as plasma micronutrients and urinary arsenic profiles on urothelial carcinoma (UC) risk. Urinary 8-OHdG was measured using high-sensitivity enzyme-linked immunosorbent assay kits. The urinary arsenic species were analyzed using high-performance liquid chromatography and hydride generator-atomic absorption spectrometry. Plasma micronutrient levels were analyzed using reversed-phase high-performance liquid chromatography. The present study showed a significant protective effect of plasma alpha-tocopherol on UC risk. Plasma alpha-tocopherol levels were significantly inversely related to urinary total arsenic concentrations and inorganic arsenic percentage (InAs%), and significantly positively related to dimethylarsinic acid percentage (DMA%). There were no correlations between plasma micronutrients and urinary 8-OHdG. Study participants with lower alpha-tocopherol and higher urinary total arsenic, higher InAs%, higher MMA%, and lower DMA% had a higher UC risk than those with higher alpha-tocopherol and lower urinary total arsenic, lower InAs%, lower MMA%, and higher DMA%. These results suggest that plasma alpha-tocopherol might modify the risk of inorganic arsenic-related UC.

AB - Arsenic plays an important role in producing oxidative stress in cultured cells. To investigate the interaction between high oxidative stress and low arsenic methylation capacity on arsenic carcinogenesis, a case-control study was conducted to evaluate the relationship among the indices of oxidative stress, such as urinary 8-hydroxydeoxyquanine (8-OHdG), as well as plasma micronutrients and urinary arsenic profiles on urothelial carcinoma (UC) risk. Urinary 8-OHdG was measured using high-sensitivity enzyme-linked immunosorbent assay kits. The urinary arsenic species were analyzed using high-performance liquid chromatography and hydride generator-atomic absorption spectrometry. Plasma micronutrient levels were analyzed using reversed-phase high-performance liquid chromatography. The present study showed a significant protective effect of plasma alpha-tocopherol on UC risk. Plasma alpha-tocopherol levels were significantly inversely related to urinary total arsenic concentrations and inorganic arsenic percentage (InAs%), and significantly positively related to dimethylarsinic acid percentage (DMA%). There were no correlations between plasma micronutrients and urinary 8-OHdG. Study participants with lower alpha-tocopherol and higher urinary total arsenic, higher InAs%, higher MMA%, and lower DMA% had a higher UC risk than those with higher alpha-tocopherol and lower urinary total arsenic, lower InAs%, lower MMA%, and higher DMA%. These results suggest that plasma alpha-tocopherol might modify the risk of inorganic arsenic-related UC.

KW - 8-OHdG

KW - Plasma micronutrients

KW - Urinary arsenic profiles

KW - Urothelial carcinoma

UR - http://www.scopus.com/inward/record.url?scp=78751704792&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78751704792&partnerID=8YFLogxK

U2 - 10.1016/j.scitotenv.2010.11.037

DO - 10.1016/j.scitotenv.2010.11.037

M3 - Article

VL - 409

SP - 1039

EP - 1045

JO - Science of the Total Environment

JF - Science of the Total Environment

SN - 0048-9697

IS - 6

ER -