Protective effects of L-arginine on pulmonary oxidative stress and antioxidant defenses during exhaustive exercise in rats

Wan Teng Lin, Suh-Ching Yang, Kung Tung Chen, Chi Chang Huang, Ning Yuean Lee

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Aim: To assess the effects of L-arginine (L-Arg) supplementation on pulmonary oxidative stress and antioxidant defenses in rats after exhaustive exercise. Methods: Rats were randomly divided into four groups: sedentary control (SC), sedentary control with L-Arg treatment (SC+Arg), exhaustive exercise with control diet (E) and exhaustive exercise with L-Arg treatment (E+Arg). Rats in groups SC+Arg and E+Arg received a 2% L-Arg diet. Rats in groups E and E+Arg underwent an exhaustive running test on a motorized treadmill. Pulmonary oxidative stress indices [xanthine oxidase (XO), myeloperoxidase (MPO), and malondialdehyde (MDA)] and antioxidant defense systems [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione reductase (GR), and glutathione (GSH)] were investigated in this study. Results: L-Arg supplementation significantly reduced exercise-induced elevations of XO and MPO activities in lung. L-Arg reversed the exercise-induced increase in SOD and GR activities, but increased CAT and GPX activities. L-Arg administration also significantly increased the GSH levels in plasma. Conclusion: L-Arg supplementation can prevent elevations of XO and MPO activities in the lung and favorably influence pulmonary antioxidant defense systems after exhaustive exercise.

Original languageEnglish
Pages (from-to)992-999
Number of pages8
JournalActa Pharmacologica Sinica
Volume26
Issue number8
DOIs
Publication statusPublished - Aug 2005

Fingerprint

Oxidative stress
Arginine
Rats
Oxidative Stress
Antioxidants
Xanthine Oxidase
Lung
Peroxidase
Glutathione Reductase
Nutrition
Glutathione Peroxidase
Catalase
Superoxide Dismutase
Diet
Exercise equipment
Control Groups
Malondialdehyde
Glutathione
Plasmas

Keywords

  • Exhaustive exercise
  • L-arginine
  • Lung
  • Myeloperoxidase
  • Oxidative stress
  • Xanthine oxidase

ASJC Scopus subject areas

  • Chemistry(all)
  • Pharmacology

Cite this

Protective effects of L-arginine on pulmonary oxidative stress and antioxidant defenses during exhaustive exercise in rats. / Lin, Wan Teng; Yang, Suh-Ching; Chen, Kung Tung; Huang, Chi Chang; Lee, Ning Yuean.

In: Acta Pharmacologica Sinica, Vol. 26, No. 8, 08.2005, p. 992-999.

Research output: Contribution to journalArticle

Lin, Wan Teng ; Yang, Suh-Ching ; Chen, Kung Tung ; Huang, Chi Chang ; Lee, Ning Yuean. / Protective effects of L-arginine on pulmonary oxidative stress and antioxidant defenses during exhaustive exercise in rats. In: Acta Pharmacologica Sinica. 2005 ; Vol. 26, No. 8. pp. 992-999.
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