Protective effects of garcinol on dimethylnitrosamine-induced liver fibrosis in rats

Wei Lun Hung, Mei Ling Tsai, Pei Pei Sun, Chen Yu Tsai, Chin Chou Yang, Chi Tang Ho, An Chin Cheng, Min Hsiung Pan

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Garcinol, a polyisoprenylated benzophenone derivative, mainly isolated from Garcinia indica fruit rind, has been suggested to exhibit many biological benefits including antioxidative, anti-inflammatory, and anti-tumor activities. The aim of this study is to evaluate the protective effects of garcinol on dimethylnitrosamine (DMN)-induced liver fibrosis in rats. The administration of DMN for six consecutive weeks resulted in the decrease of body weights, the elevation of serum aminotransferases, as well as histological lesions in livers. However, oral administration of garcinol remarkably inhibited the elevation of aspartate transaminase (AST) and relieved liver damage induced by DMN. Furthermore, our results revealed that garcinol not only effectively reduced the accumulation of extracellular matrix (ECM) components but also inhibited the expression of α-smooth muscle actin (α-SMA) in livers. The expression of transforming growth factor-β1 (TGF-β1) and the phosphorylation of Smad 2 and Smad 3 were also suppressed by garcinol supplementation. In conclusion, our current study suggested that garcinol exerted hepatoprotective and anti-fibrotic effects against DMN-induced liver injury in rats.

Original languageEnglish
Pages (from-to)2883-2891
Number of pages9
JournalFood and Function
Volume5
Issue number11
DOIs
Publication statusPublished - Jan 1 2014
Externally publishedYes

Fingerprint

Dimethylnitrosamine
liver cirrhosis
Liver Cirrhosis
protective effect
liver
rats
Liver
benzophenone
transforming growth factors
fruit peels
transaminases
Garcinia
extracellular matrix
aspartate transaminase
lesions (animal)
smooth muscle
oral administration
actin
phosphorylation
chemical derivatives

ASJC Scopus subject areas

  • Food Science

Cite this

Hung, W. L., Tsai, M. L., Sun, P. P., Tsai, C. Y., Yang, C. C., Ho, C. T., ... Pan, M. H. (2014). Protective effects of garcinol on dimethylnitrosamine-induced liver fibrosis in rats. Food and Function, 5(11), 2883-2891. https://doi.org/10.1039/c4fo00342j

Protective effects of garcinol on dimethylnitrosamine-induced liver fibrosis in rats. / Hung, Wei Lun; Tsai, Mei Ling; Sun, Pei Pei; Tsai, Chen Yu; Yang, Chin Chou; Ho, Chi Tang; Cheng, An Chin; Pan, Min Hsiung.

In: Food and Function, Vol. 5, No. 11, 01.01.2014, p. 2883-2891.

Research output: Contribution to journalArticle

Hung, WL, Tsai, ML, Sun, PP, Tsai, CY, Yang, CC, Ho, CT, Cheng, AC & Pan, MH 2014, 'Protective effects of garcinol on dimethylnitrosamine-induced liver fibrosis in rats', Food and Function, vol. 5, no. 11, pp. 2883-2891. https://doi.org/10.1039/c4fo00342j
Hung, Wei Lun ; Tsai, Mei Ling ; Sun, Pei Pei ; Tsai, Chen Yu ; Yang, Chin Chou ; Ho, Chi Tang ; Cheng, An Chin ; Pan, Min Hsiung. / Protective effects of garcinol on dimethylnitrosamine-induced liver fibrosis in rats. In: Food and Function. 2014 ; Vol. 5, No. 11. pp. 2883-2891.
@article{b8a3429dc1444d9080d43f4543f88935,
title = "Protective effects of garcinol on dimethylnitrosamine-induced liver fibrosis in rats",
abstract = "Garcinol, a polyisoprenylated benzophenone derivative, mainly isolated from Garcinia indica fruit rind, has been suggested to exhibit many biological benefits including antioxidative, anti-inflammatory, and anti-tumor activities. The aim of this study is to evaluate the protective effects of garcinol on dimethylnitrosamine (DMN)-induced liver fibrosis in rats. The administration of DMN for six consecutive weeks resulted in the decrease of body weights, the elevation of serum aminotransferases, as well as histological lesions in livers. However, oral administration of garcinol remarkably inhibited the elevation of aspartate transaminase (AST) and relieved liver damage induced by DMN. Furthermore, our results revealed that garcinol not only effectively reduced the accumulation of extracellular matrix (ECM) components but also inhibited the expression of α-smooth muscle actin (α-SMA) in livers. The expression of transforming growth factor-β1 (TGF-β1) and the phosphorylation of Smad 2 and Smad 3 were also suppressed by garcinol supplementation. In conclusion, our current study suggested that garcinol exerted hepatoprotective and anti-fibrotic effects against DMN-induced liver injury in rats.",
author = "Hung, {Wei Lun} and Tsai, {Mei Ling} and Sun, {Pei Pei} and Tsai, {Chen Yu} and Yang, {Chin Chou} and Ho, {Chi Tang} and Cheng, {An Chin} and Pan, {Min Hsiung}",
year = "2014",
month = "1",
day = "1",
doi = "10.1039/c4fo00342j",
language = "English",
volume = "5",
pages = "2883--2891",
journal = "Food and Function",
issn = "2042-6496",
publisher = "Royal Society of Chemistry",
number = "11",

}

TY - JOUR

T1 - Protective effects of garcinol on dimethylnitrosamine-induced liver fibrosis in rats

AU - Hung, Wei Lun

AU - Tsai, Mei Ling

AU - Sun, Pei Pei

AU - Tsai, Chen Yu

AU - Yang, Chin Chou

AU - Ho, Chi Tang

AU - Cheng, An Chin

AU - Pan, Min Hsiung

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Garcinol, a polyisoprenylated benzophenone derivative, mainly isolated from Garcinia indica fruit rind, has been suggested to exhibit many biological benefits including antioxidative, anti-inflammatory, and anti-tumor activities. The aim of this study is to evaluate the protective effects of garcinol on dimethylnitrosamine (DMN)-induced liver fibrosis in rats. The administration of DMN for six consecutive weeks resulted in the decrease of body weights, the elevation of serum aminotransferases, as well as histological lesions in livers. However, oral administration of garcinol remarkably inhibited the elevation of aspartate transaminase (AST) and relieved liver damage induced by DMN. Furthermore, our results revealed that garcinol not only effectively reduced the accumulation of extracellular matrix (ECM) components but also inhibited the expression of α-smooth muscle actin (α-SMA) in livers. The expression of transforming growth factor-β1 (TGF-β1) and the phosphorylation of Smad 2 and Smad 3 were also suppressed by garcinol supplementation. In conclusion, our current study suggested that garcinol exerted hepatoprotective and anti-fibrotic effects against DMN-induced liver injury in rats.

AB - Garcinol, a polyisoprenylated benzophenone derivative, mainly isolated from Garcinia indica fruit rind, has been suggested to exhibit many biological benefits including antioxidative, anti-inflammatory, and anti-tumor activities. The aim of this study is to evaluate the protective effects of garcinol on dimethylnitrosamine (DMN)-induced liver fibrosis in rats. The administration of DMN for six consecutive weeks resulted in the decrease of body weights, the elevation of serum aminotransferases, as well as histological lesions in livers. However, oral administration of garcinol remarkably inhibited the elevation of aspartate transaminase (AST) and relieved liver damage induced by DMN. Furthermore, our results revealed that garcinol not only effectively reduced the accumulation of extracellular matrix (ECM) components but also inhibited the expression of α-smooth muscle actin (α-SMA) in livers. The expression of transforming growth factor-β1 (TGF-β1) and the phosphorylation of Smad 2 and Smad 3 were also suppressed by garcinol supplementation. In conclusion, our current study suggested that garcinol exerted hepatoprotective and anti-fibrotic effects against DMN-induced liver injury in rats.

UR - http://www.scopus.com/inward/record.url?scp=84908130162&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908130162&partnerID=8YFLogxK

U2 - 10.1039/c4fo00342j

DO - 10.1039/c4fo00342j

M3 - Article

VL - 5

SP - 2883

EP - 2891

JO - Food and Function

JF - Food and Function

SN - 2042-6496

IS - 11

ER -