Protective effects of adenosine A2A receptor agonist in ventilator-induced lung injury in rats

Chin Ming Chen, Oscar Penuelas, Kieran Quinn, Kuo Chen Cheng, Chien Feng Li, Haibo Zhang, Arthur S. Slutsky

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objectives: Mechanical ventilation is associated with over-whelming inflammatory responses that are associated with ventilator-induced lung injury (VILI) in patients with acute respiratory distress syndrome. The activation of adenosine A2A receptors has been reported to attenuate inflammatory cascades. Hypothesis: The administration of A2A receptors agonist ameliorates VILI. Methods: Rats were subjected to hemorrhagic shock and resuscitation as a first hit to induce systemic inflammation. The animals randomly received the selective A2A receptor agonist CGS-21680 or a vehicle control in a blinded fashion at the onset of resuscitation phase. They were then randomized to receive mechanical ventilation as a second hit with a high tidal volume of 20 mL/kg and zero positive end-expiratory pressure, or a low tidal volume of 6 mL/kg with positive end-expiratory pressure of 5 cm H 2O. Results: The administration of CGS-21680 attenuated lung injury as evidenced by a decrease in respiratory elastance, lung edema, lung injury scores, neutrophil recruitment in the lung, and production of inflammatory cytokines, compared with the vehicle-treated animals. Conclusions: The selective A2A receptor agonist may have a place as a novel therapeutic approach in reducing VILI.

Original languageEnglish
Pages (from-to)2235-2241
Number of pages7
JournalCritical Care Medicine
Volume37
Issue number7
DOIs
Publication statusPublished - Jul 2009

Fingerprint

Adenosine A2 Receptor Agonists
Ventilator-Induced Lung Injury
Positive-Pressure Respiration
Tidal Volume
Lung Injury
Artificial Respiration
Resuscitation
Adenosine A2A Receptors
Lung
Hemorrhagic Shock
Neutrophil Infiltration
Adult Respiratory Distress Syndrome
Edema
Cytokines
Inflammation
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine
Therapeutics

Keywords

  • Acute Respiratory distress syndrome
  • Inflammation
  • Neutrophils

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Chen, C. M., Penuelas, O., Quinn, K., Cheng, K. C., Li, C. F., Zhang, H., & Slutsky, A. S. (2009). Protective effects of adenosine A2A receptor agonist in ventilator-induced lung injury in rats. Critical Care Medicine, 37(7), 2235-2241. https://doi.org/10.1097/CCM.0b013e3181a55273

Protective effects of adenosine A2A receptor agonist in ventilator-induced lung injury in rats. / Chen, Chin Ming; Penuelas, Oscar; Quinn, Kieran; Cheng, Kuo Chen; Li, Chien Feng; Zhang, Haibo; Slutsky, Arthur S.

In: Critical Care Medicine, Vol. 37, No. 7, 07.2009, p. 2235-2241.

Research output: Contribution to journalArticle

Chen, CM, Penuelas, O, Quinn, K, Cheng, KC, Li, CF, Zhang, H & Slutsky, AS 2009, 'Protective effects of adenosine A2A receptor agonist in ventilator-induced lung injury in rats', Critical Care Medicine, vol. 37, no. 7, pp. 2235-2241. https://doi.org/10.1097/CCM.0b013e3181a55273
Chen, Chin Ming ; Penuelas, Oscar ; Quinn, Kieran ; Cheng, Kuo Chen ; Li, Chien Feng ; Zhang, Haibo ; Slutsky, Arthur S. / Protective effects of adenosine A2A receptor agonist in ventilator-induced lung injury in rats. In: Critical Care Medicine. 2009 ; Vol. 37, No. 7. pp. 2235-2241.
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