The American ginseng (Panax quinquefolium L.) is widely used in the oriental traditional medicine. The present study investigates the protection effects of Panax quinquefolium extract granule (PQEG) against chemical-induced gastric mucosal injury. In vitro cell damage was induced by incubating rat gastric mucosal cells, RGM1, with indomethacin (INDO) and quantitated by methylthiazole-tetrazolium (MTT) assay. In vivo gastric damage was induced by 70 % ethanol 10 mL/kg and the ulcer index was calculated the gastric mucosal damage percentage. In vitro study, Panax quinquefolium extract granule revealed significant protection on rat gastric mucosal cells, RGM1, from indomethacin-caused cytotoxicity, with an EC50 of 694.4 mg/kg (95 % CL: 582.2-872.6). In vivo studies showed pretreatment with Panax quinquefolium extract granule caused a significant and dose-dependent inhibition of ethanol-induced gastric mucosal damage, with an ED50 of 588.7 mg/kg (95 % CL: 426.8-850.3). In conclusion, Panax quinquefolium treatment shows protective role in indomethacin- induced gastric mucosa cell injury in vitro and ethanol-induced gastric mucosa lesions in vivo.
|Number of pages||4|
|Journal||Asian Journal of Chemistry|
|Publication status||Published - 2012|
- American ginseng
- Gastric mucosal injury
- Panax quinquefolium
ASJC Scopus subject areas