Protective effect of non-ionizing radiation from ceramic far infrared (cFIR)-emitting material against oxidative stress on human breast epithelial cells

Ting-Kai Leung, Chi-Ming Lee, Shoei Loong Lin, Chih Hsiung Wu, Jeng Fong Chiou, Pai Jung Huang, Li Kuo Shen, Chin Sheng Hung, Yuan Soon Ho, Hung Jung Wang, Ching Huei Kung, Yi Hsiang Lin, Huey Min Yeh

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Previous research has identified that ceramic far infrared (cFIR)-emitting material can modulate various biological processes, particularly those involving hydrogen peroxide scavenging and antioxidant activities. The present study treated MCF-10A cells with 50 and 100 μM hydrogen peroxide before incubating them for 24 h on the top of The present study treated MCF-10A cells with 50 and 100 μM hydrogen peroxide before incubating them for 24 h on the top of cFIR or control powder. cFIR or control powder. Cells were also treated with ionizing radiation from a fluoroscopic X-ray source to induce cell damage and cultured for 48 h beneath cFIR or control powder. The effects of cFIR on cell survival were evaluated using XTT and MTT assays. A total accumulated radiation dose of 1 Gy to 2 Gy was sufficient to cause cell damage and reduce cell viability. In both the hydrogen peroxide toxicity and radiation exposure experimental models, the cFIR groups demonstrated significantly higher cell survival rates than those of the control groups (p <0.05). Considering the relationship between indirect-ionizing-radiation- and oxidative-stress- induced cell damage and the accumulation of free radicals, these results indicate that the protection of cFIR against ionizing radiation is predominantly through an antioxidant mechanism. cFIR-emitting material has potential use in reducing radiation damage caused by medical instruments and radiation pollution.

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalJournal of Medical and Biological Engineering
Volume34
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

Nonionizing Radiation
Oxidative stress
Ceramics
Oxidative Stress
Breast
Epithelial Cells
Infrared radiation
Cells
Hydrogen peroxide
Hydrogen Peroxide
Ionizing radiation
Ionizing Radiation
Powders
Cell Survival
Radiation
Antioxidants
Biological Phenomena
Scavenging
Radiation damage
Free radicals

Keywords

  • Antioxidants
  • Bioceramic
  • Breast epithelial cells
  • Far-infrared rays
  • Low-dose radiation
  • Oxidative stress

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine(all)

Cite this

Protective effect of non-ionizing radiation from ceramic far infrared (cFIR)-emitting material against oxidative stress on human breast epithelial cells. / Leung, Ting-Kai; Lee, Chi-Ming; Lin, Shoei Loong; Wu, Chih Hsiung; Chiou, Jeng Fong; Huang, Pai Jung; Shen, Li Kuo; Hung, Chin Sheng; Ho, Yuan Soon; Wang, Hung Jung; Kung, Ching Huei; Lin, Yi Hsiang; Yeh, Huey Min.

In: Journal of Medical and Biological Engineering, Vol. 34, No. 1, 2014, p. 69-75.

Research output: Contribution to journalArticle

Leung, Ting-Kai ; Lee, Chi-Ming ; Lin, Shoei Loong ; Wu, Chih Hsiung ; Chiou, Jeng Fong ; Huang, Pai Jung ; Shen, Li Kuo ; Hung, Chin Sheng ; Ho, Yuan Soon ; Wang, Hung Jung ; Kung, Ching Huei ; Lin, Yi Hsiang ; Yeh, Huey Min. / Protective effect of non-ionizing radiation from ceramic far infrared (cFIR)-emitting material against oxidative stress on human breast epithelial cells. In: Journal of Medical and Biological Engineering. 2014 ; Vol. 34, No. 1. pp. 69-75.
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