Protective effect of magnolol-loaded polyketal microparticles on lipopolysaccharide-induced acute lung injury in rats

Tsuimin Tsai, Chen Yu Kao, Chun Liang Chou, Lu Chun Liu, Tz Chong Chou

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Magnolol has shown inhibitory effects on NO production and TNF-alpha production in lipopolysaccharide (LPS)-activated macrophages and LPS-induced acute lung injury; however, the poor solubility of magnolol has hindered its clinical success. In this study, magnolol-loaded microparticles were prepared via single emulsion method from a polyketal polymer, termed PK3. The particle sizes of magnolol-loaded PK3 microparticle is 3.73 ± 0.41 μm, and was suitable for phagocytosis by macrophages and pulmonary drug delivery. PK3 microparticles exhibited excellent biocompatibility both in vitro and in vivo. More importantly, intratracheal delivery of these magnolol-loaded microparticles significantly reduced the lung inflammatory responses at low dosage of magnolol (0.5 mg/kg), and have great clinical potential in treating acute lung injury.

Original languageEnglish
Pages (from-to)401-411
Number of pages11
JournalJournal of Microencapsulation
Volume33
Issue number5
DOIs
Publication statusPublished - Jul 3 2016

Keywords

  • acute lung injury
  • anti-inflammatory. pulmonary drug delivery
  • Magnolol
  • polyketal microparticles

ASJC Scopus subject areas

  • Bioengineering
  • Medicine(all)
  • Pharmaceutical Science
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Colloid and Surface Chemistry

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