Protective effect of Grewia asiatica leaves extract in animal models of epilepsy and anxiety

Shabnampreet Kaur, Atamjit Singh, Hasandeep Singh, Preet Mohinder Singh Bedi, Kunal Nepali, Balbir Singh, Sarabjit Kaur

Research output: Contribution to journalArticlepeer-review

Abstract

Grewia asiatica Linn. is a well-known plant for its nutritional and therapeutic attributes. It has been mentioned in ancient Indian literature as Rasayana due to its stimulant and tonic effects. Thus, present investigation was carried out to evaluate the antiepileptic and anxiolytic action of G. asiatica Linn. leaves using animal models. Methanol extract at dose levels of 100 and 200 mg/kg was capable of providing protection against both pentylenetetrazole and maximal electroshock induced seizures in mice. Extract also showed significant anxiolytic activity in elevated plus maze, light/dark box and mirror chamber mice models at same dose levels. Results of this study indicated that the methanol extract of leaves of G. asiatica plant possess significant antiepileptic and anxiolytic effect.

Original languageEnglish
Article number100616
JournalJournal of Ayurveda and Integrative Medicine
Volume13
Issue number3
DOIs
Publication statusPublished - Jul 2022

Keywords

  • Antiepileptic
  • Anxiolytic
  • Flavonoids
  • Grewia asiatica

ASJC Scopus subject areas

  • Drug Discovery
  • Complementary and alternative medicine

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