Protective Effect of Camellia Oil (Camellia oleifera Abel.) against Ethanol-Induced Acute Oxidative Injury of the Gastric Mucosa in Mice

Pang Shuo Tu, Yu Tang Tung, Wei Ting Lee, Gow Chin Yen

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Camellia oil, a common edible oil in Taiwan and China, has health effects for the gastrointestinal tract in folk medicine, and it contains abundant unsaturated fatty acids and phytochemicals. However, the preventive effect of camellia oil on ethanol-induced gastric ulcers remains unclear. This study was aimed to evaluate the preventive effect of camellia oil on ethanol-induced gastric injury in vitro and in vivo as well as its mechanisms of action. In an in vitro study, our results showed that pretreatment of RGM-1 cells with camellia oil enhanced the migration ability as well as increased heat shock protein expression and reduced apoptotic protein expression. In animal experiments, mice pretreated with camellia oil effectively showed improved ethanol-induced acute injury of the gastric muscosa and oxidative damage through the enhancement of antioxidant enzyme activities and heat shock protein and PGE2 production, as well as the suppression of lipid peroxidation, apoptosis-related proteins, pro-inflammatory cytokines, and NO production. Histological injury score and hemorrhage score in ethanol-induced gastric mucosal damage dramatically elevated from the control group (0.00 ± 0.0) to 3.40 ± 0.7 and 2.60 ± 0.5, respectively. However, treatments with camellia oil or olive oil (2 mL/kg bw) and lansoprazole (30 mg/kg bw) showed significant decreases in elevation of injury score and hemorrhage score (p < 0.05). Therefore, camellia oil has the potential to ameliorate ethanol-induced acute gastric mucosal injury through the inhibition of inflammation and oxidative stress.

Original languageEnglish
Pages (from-to)4932-4941
Number of pages10
JournalJournal of Agricultural and Food Chemistry
Volume65
Issue number24
DOIs
Publication statusPublished - Jun 21 2017

Fingerprint

Camellia
Camellia oleifera
gastric mucosa
Gastric Mucosa
protective effect
Oils
Ethanol
ethanol
oils
mice
Wounds and Injuries
Stomach
stomach
Heat-Shock Proteins
heat shock proteins
hemorrhage
Lansoprazole
protein synthesis
Hemorrhage
Oxidative stress

Keywords

  • camellia oil
  • ethanol
  • gastric ulcer
  • gastrointestinal health
  • RGM-1

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

Cite this

Protective Effect of Camellia Oil (Camellia oleifera Abel.) against Ethanol-Induced Acute Oxidative Injury of the Gastric Mucosa in Mice. / Tu, Pang Shuo; Tung, Yu Tang; Lee, Wei Ting; Yen, Gow Chin.

In: Journal of Agricultural and Food Chemistry, Vol. 65, No. 24, 21.06.2017, p. 4932-4941.

Research output: Contribution to journalArticle

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