Protective effect of caffeic acid on paclitaxel induced anti-proliferation and apoptosis of lung cancer cells involves NF-κb pathway

Chien Liang Lin, Ruei Feng Chen, Jeff Yi Fu Chen, Ying Chieh Chu, Hui Min Wang, Han Lin Chou, Wei Chiao Chang, Yao Fong, Wen Tsan Chang, Chang Yi Wu, Chien Chih Chiu

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Caffeic acid (CA), a natural phenolic compound, is abundant in medicinal plants. CA possesses multiple biological effects such as anti-bacterial and anti-cancer growth. CA was also reported to induce fore stomach and kidney tumors in a mouse model. Here we used two human lung cancer cell lines, A549 and H1299, to clarify the role of CA in cancer cell proliferation. The growth assay showed that CA moderately promoted the proliferation of the lung cancer cells. Furthermore, pre-treatment of CA rescues the proliferation inhibition induced by a sub-IC50 dose of paclitaxel (PTX), an anticancer drug. Western blot showed that CA up-regulated the pro-survival proteins survivin and Bcl-2, the down-stream targets of NF-κB. This is consistent with the observation that CA induced nuclear translocation of NF-κB p65. Our study suggested that the pro-survival effect of CA on PTX-treated lung cancer cells is mediated through a NF-κB signaling pathway. This may provide mechanistic insights into the chemoresistance of cancer calls.

Original languageEnglish
Pages (from-to)6236-6245
Number of pages10
JournalInternational Journal of Molecular Sciences
Volume13
Issue number5
DOIs
Publication statusPublished - May 2012
Externally publishedYes

Keywords

  • Bcl-2
  • Caffeic acid
  • NF κB
  • Non-small cell lung cancer
  • Paclitaxel
  • Survivin

ASJC Scopus subject areas

  • Computer Science Applications
  • Molecular Biology
  • Catalysis
  • Inorganic Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Medicine(all)

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