Protective and therapeutic effects of huanglian-jie-du-tang on hepatotoxin-induced liver injuries

Song-Chow Lin, Chun Ching Lin, Fung Jou Lu, Yun Ho Lin, Ching Hscin Chen

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19 Citations (Scopus)

Abstract

The hepatoprotective effect of Huanglian-Jie-Du-Tang (HLJDT), a Chinese medicinal prescription, was investigated in three kinds of experimental models. The animals were treated with HLJDT (300 mg/kg, p.o.) thrice at 2, 4 and 10 hours after administration with carbon tetrachloride (32 μl/kg, i.p.), acetaminophen (600 mg/kg, i.p.) and β-D-galactosamine (188 mg/kg, i.p.). Significant hepatoprotective effects on carbon tetrachloride and actaminophen induced liver injuries were noted, but no significant effect on β-D-galactosamine induced liver injury was observed. These hepatoprotective effects were evidenced by comparing the serum glutamate oxaloacetate transaminase (SCOT) and serum glutamate pyruvate transaminase (SGPT) levels in HLJDT treated and untreated groups. Serum enzyme activities in the carbon tetrachloride and acetaminophen experiments were significantly lower in the treated groups while the herbal prescription has no effect on the β-D-galactosamine experiment. These results demonstrated that Huanglian-Jie-Du-Tang has a hepatoprotective effect against experimental liver injuries induced by specific hepatotoxins, and therefore may be useful in treating some, but not all, liver injuries.

Original languageEnglish
Pages (from-to)219-229
Number of pages11
JournalAmerican Journal of Chinese Medicine
Volume24
Issue number3-4
Publication statusPublished - 1996

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Therapeutic Uses
Galactosamine
Carbon Tetrachloride
Liver
Wounds and Injuries
Acetaminophen
Transaminases
Prescriptions
Glutamic Acid
Serum
Oxaloacetic Acid
Pyruvic Acid
Theoretical Models
oren gedoku to
Enzymes

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Protective and therapeutic effects of huanglian-jie-du-tang on hepatotoxin-induced liver injuries. / Lin, Song-Chow; Lin, Chun Ching; Lu, Fung Jou; Lin, Yun Ho; Chen, Ching Hscin.

In: American Journal of Chinese Medicine, Vol. 24, No. 3-4, 1996, p. 219-229.

Research output: Contribution to journalArticle

Lin, Song-Chow ; Lin, Chun Ching ; Lu, Fung Jou ; Lin, Yun Ho ; Chen, Ching Hscin. / Protective and therapeutic effects of huanglian-jie-du-tang on hepatotoxin-induced liver injuries. In: American Journal of Chinese Medicine. 1996 ; Vol. 24, No. 3-4. pp. 219-229.
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