Protective and therapeutic effects of ban-zhi-lian on hepatotoxin-induced liver injuries.

Song-Chow Lin, C. C. Lin, Y. H. Lin, C. H. Chen

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The hepatoprotective effect of Ban-zhi-lian was investigated in three kinds of experimental models. The animals were treated with Ban-zhi-lian (300 mg/kg, p.o.) at 2,4, and 10 hours after carbon tetrachloride (32 l/kg, i.p.), acetaminophen (600 mg/kg, i.p.), and beta-D-galactosamine (188 mg/kg, i.p.) administration. Significant protective effects from these hepatotoxins were expressed. This protection was evidenced by comparing the serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), and histopathologic examination in animals treated and untreated with Ban-zhi-lian. Serum enzyme activities were significantly lower in Ban-zhi-lian-treated groups. In the histopathologic observation, liver damage induced by three hepatotoxins was markedly improved in Ban-zhi-lian treated animals. These results demonstrated that Ban-zhi-lian has a protective effect against experimental liver damage induced by various hepatotoxins.

Original languageEnglish
Pages (from-to)29-42
Number of pages14
JournalAmerican Journal of Chinese Medicine
Volume22
Issue number1
Publication statusPublished - 1994

Fingerprint

Therapeutic Uses
Liver
Wounds and Injuries
Transaminases
Glutamic Acid
Serum
Oxaloacetic Acid
Galactosamine
Carbon Tetrachloride
Acetaminophen
Pyruvic Acid
ban-zhi-lian
Theoretical Models
Observation
Enzymes

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Protective and therapeutic effects of ban-zhi-lian on hepatotoxin-induced liver injuries. / Lin, Song-Chow; Lin, C. C.; Lin, Y. H.; Chen, C. H.

In: American Journal of Chinese Medicine, Vol. 22, No. 1, 1994, p. 29-42.

Research output: Contribution to journalArticle

@article{7d9e15c8eb564ba49913e93f05f0e956,
title = "Protective and therapeutic effects of ban-zhi-lian on hepatotoxin-induced liver injuries.",
abstract = "The hepatoprotective effect of Ban-zhi-lian was investigated in three kinds of experimental models. The animals were treated with Ban-zhi-lian (300 mg/kg, p.o.) at 2,4, and 10 hours after carbon tetrachloride (32 l/kg, i.p.), acetaminophen (600 mg/kg, i.p.), and beta-D-galactosamine (188 mg/kg, i.p.) administration. Significant protective effects from these hepatotoxins were expressed. This protection was evidenced by comparing the serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), and histopathologic examination in animals treated and untreated with Ban-zhi-lian. Serum enzyme activities were significantly lower in Ban-zhi-lian-treated groups. In the histopathologic observation, liver damage induced by three hepatotoxins was markedly improved in Ban-zhi-lian treated animals. These results demonstrated that Ban-zhi-lian has a protective effect against experimental liver damage induced by various hepatotoxins.",
author = "Song-Chow Lin and Lin, {C. C.} and Lin, {Y. H.} and Chen, {C. H.}",
year = "1994",
language = "English",
volume = "22",
pages = "29--42",
journal = "American Journal of Chinese Medicine",
issn = "0192-415X",
publisher = "World Scientific Publishing Co. Pte Ltd",
number = "1",

}

TY - JOUR

T1 - Protective and therapeutic effects of ban-zhi-lian on hepatotoxin-induced liver injuries.

AU - Lin, Song-Chow

AU - Lin, C. C.

AU - Lin, Y. H.

AU - Chen, C. H.

PY - 1994

Y1 - 1994

N2 - The hepatoprotective effect of Ban-zhi-lian was investigated in three kinds of experimental models. The animals were treated with Ban-zhi-lian (300 mg/kg, p.o.) at 2,4, and 10 hours after carbon tetrachloride (32 l/kg, i.p.), acetaminophen (600 mg/kg, i.p.), and beta-D-galactosamine (188 mg/kg, i.p.) administration. Significant protective effects from these hepatotoxins were expressed. This protection was evidenced by comparing the serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), and histopathologic examination in animals treated and untreated with Ban-zhi-lian. Serum enzyme activities were significantly lower in Ban-zhi-lian-treated groups. In the histopathologic observation, liver damage induced by three hepatotoxins was markedly improved in Ban-zhi-lian treated animals. These results demonstrated that Ban-zhi-lian has a protective effect against experimental liver damage induced by various hepatotoxins.

AB - The hepatoprotective effect of Ban-zhi-lian was investigated in three kinds of experimental models. The animals were treated with Ban-zhi-lian (300 mg/kg, p.o.) at 2,4, and 10 hours after carbon tetrachloride (32 l/kg, i.p.), acetaminophen (600 mg/kg, i.p.), and beta-D-galactosamine (188 mg/kg, i.p.) administration. Significant protective effects from these hepatotoxins were expressed. This protection was evidenced by comparing the serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), and histopathologic examination in animals treated and untreated with Ban-zhi-lian. Serum enzyme activities were significantly lower in Ban-zhi-lian-treated groups. In the histopathologic observation, liver damage induced by three hepatotoxins was markedly improved in Ban-zhi-lian treated animals. These results demonstrated that Ban-zhi-lian has a protective effect against experimental liver damage induced by various hepatotoxins.

UR - http://www.scopus.com/inward/record.url?scp=0028187126&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028187126&partnerID=8YFLogxK

M3 - Article

C2 - 8030617

AN - SCOPUS:0028187126

VL - 22

SP - 29

EP - 42

JO - American Journal of Chinese Medicine

JF - American Journal of Chinese Medicine

SN - 0192-415X

IS - 1

ER -