Prostate cancer and antidepressants

A nationwide population-based nested case-control study

Wei Yu Lin, Vincent Chin Hung Chen, Wei Che Chiu, Samantha J. Yim, Peter T. Ho, Roger S. McIntyre, Mong Liang Lu, Shui I. Wu

Research output: Contribution to journalArticle

Abstract

Background We aimed to evaluate the association between antidepressant and prostate cancer by comparing exposures to antidepressants between those with and without prostate cancer. Methods A nationwide insurance claims database was used to identify our case subjects. Age- and gender-matched controls were selected at a 1:5 ratio. Conditional logistic regression model was used. Results 11,515 patients with prostate cancer were identified and matched with 55,373 controls. No increased associations between prostate cancer and most classes of antidepressants were found. However, a positive association with adjusted odds ratios ranged from 1.20 to 1.35 was noted in different doses of imipramine. Nevertheless, this association became statistically insignificant at higher cumulative doses. Conclusions Our results indicate that there is no association between mechanistically dissimilar antidepressants and increased hazard for prostate cancer.

Original languageEnglish
Pages (from-to)834-839
Number of pages6
JournalJournal of Affective Disorders
Volume227
DOIs
Publication statusPublished - Feb 1 2018

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Antidepressive Agents
Case-Control Studies
Prostatic Neoplasms
Population
Logistic Models
Imipramine
Insurance
Odds Ratio
Databases

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Lin, W. Y., Chen, V. C. H., Chiu, W. C., Yim, S. J., Ho, P. T., McIntyre, R. S., ... Wu, S. I. (2018). Prostate cancer and antidepressants: A nationwide population-based nested case-control study. Journal of Affective Disorders, 227, 834-839. https://doi.org/10.1016/j.jad.2017.11.039

Prostate cancer and antidepressants : A nationwide population-based nested case-control study. / Lin, Wei Yu; Chen, Vincent Chin Hung; Chiu, Wei Che; Yim, Samantha J.; Ho, Peter T.; McIntyre, Roger S.; Lu, Mong Liang; Wu, Shui I.

In: Journal of Affective Disorders, Vol. 227, 01.02.2018, p. 834-839.

Research output: Contribution to journalArticle

Lin, Wei Yu ; Chen, Vincent Chin Hung ; Chiu, Wei Che ; Yim, Samantha J. ; Ho, Peter T. ; McIntyre, Roger S. ; Lu, Mong Liang ; Wu, Shui I. / Prostate cancer and antidepressants : A nationwide population-based nested case-control study. In: Journal of Affective Disorders. 2018 ; Vol. 227. pp. 834-839.
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