Prospective staging evaluation of patients with cutaneous T-cell lymphomas. Demonstration of a high frequency of extracutaneous dissemination

P. A. Bunn, M. S. Huberman, J. Whang-Peng, G. P. Schechter, J. G. Guccion, M. J. Matthews, A. F. Gazdar, N. R. Dunnick, A. B. Fischmann, D. C. Ihde, M. H. Cohen, B. Fossieck, J. D. Minna

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Abstract

A prospective pretreatment staging evaluation was done on 49 consecutive patients with mycosis fungoides or the Sezary syndrome to study patterns of disease spread and prognostic factors. Routine staging procedures included complete blood count, blood chemistries, chest roentgenogram, lymphangiogram, radionuclide scans, bone marrow aspiration and biopsy, liver biopsy, and lymph node biopsy. Special evaluations included cytogenetic analysis, electron microscopy, and T-cell cytology. Extracutaneous lymphoma was documented by light microscopy in 51% of patients and by the three special procedures in 88%. Extracutaneous lymphoma was most frequent in blood and lymph nodes; 18% of patients had visceral involvement. Patients with generalized erythroderma had a higher frequency of extracutaneous disease than did patients with cutaneous plaques and tumors by both light microscopy and special studies. Survival was directly related to the type of skin involvement and the presence or absence of extracutaneous disease. Systemic dissemination of cutaneous T-cell lymphoma is frequent, generally asymptomatic, and develops early via the circulation. These findings may explain why cutaneous therapies are associated with a high frequency of relapse.

Original languageEnglish
Pages (from-to)223-230
Number of pages8
JournalAnnals of Internal Medicine
Volume93
Issue number2
Publication statusPublished - Oct 28 1980
Externally publishedYes

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Cutaneous T-Cell Lymphoma
Skin
Microscopy
Lymphoma
Lymph Nodes
Sezary Syndrome
Exfoliative Dermatitis
Biopsy
Light
Mycosis Fungoides
Blood Cell Count
Cytogenetic Analysis
Needle Biopsy
Radioisotopes
Cell Biology
Electron Microscopy
Thorax
Bone Marrow
T-Lymphocytes
Recurrence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bunn, P. A., Huberman, M. S., Whang-Peng, J., Schechter, G. P., Guccion, J. G., Matthews, M. J., ... Minna, J. D. (1980). Prospective staging evaluation of patients with cutaneous T-cell lymphomas. Demonstration of a high frequency of extracutaneous dissemination. Annals of Internal Medicine, 93(2), 223-230.

Prospective staging evaluation of patients with cutaneous T-cell lymphomas. Demonstration of a high frequency of extracutaneous dissemination. / Bunn, P. A.; Huberman, M. S.; Whang-Peng, J.; Schechter, G. P.; Guccion, J. G.; Matthews, M. J.; Gazdar, A. F.; Dunnick, N. R.; Fischmann, A. B.; Ihde, D. C.; Cohen, M. H.; Fossieck, B.; Minna, J. D.

In: Annals of Internal Medicine, Vol. 93, No. 2, 28.10.1980, p. 223-230.

Research output: Contribution to journalArticle

Bunn, PA, Huberman, MS, Whang-Peng, J, Schechter, GP, Guccion, JG, Matthews, MJ, Gazdar, AF, Dunnick, NR, Fischmann, AB, Ihde, DC, Cohen, MH, Fossieck, B & Minna, JD 1980, 'Prospective staging evaluation of patients with cutaneous T-cell lymphomas. Demonstration of a high frequency of extracutaneous dissemination', Annals of Internal Medicine, vol. 93, no. 2, pp. 223-230.
Bunn, P. A. ; Huberman, M. S. ; Whang-Peng, J. ; Schechter, G. P. ; Guccion, J. G. ; Matthews, M. J. ; Gazdar, A. F. ; Dunnick, N. R. ; Fischmann, A. B. ; Ihde, D. C. ; Cohen, M. H. ; Fossieck, B. ; Minna, J. D. / Prospective staging evaluation of patients with cutaneous T-cell lymphomas. Demonstration of a high frequency of extracutaneous dissemination. In: Annals of Internal Medicine. 1980 ; Vol. 93, No. 2. pp. 223-230.
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