Propylthiouracil-associated antineutrophil cytoplasmic antibodies resulted microscopic polyangiitis and pulmonary-renal syndrome: A case report and literature review

Chin Chung Shu, Shuen Fu Weng, Song Chou Hsieh, Tien Shang Huang

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Propylthiouracil (PTU) is a thionamide used for hyperthyroidism. Numbers of PTU induced adverse reactions such as leukopenia, rash, fever, arthritis, vasculitis, and lupus-like syndrome are reported. In addition, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis during PTU therapy was reported. Pulmonary-renal syndrome is one infrequent but life-threatening presentation of PTU-associated ANCA-positive vasculitis. We report a 45-year-old woman with pulmonary-renal syndrome presented as hemoptysis, normocytic anemia, and microscopic hematuria during the treatment of Graves' disease with PTU. Her serum perinuclear-ANCA was positive and dysmorphic red blood cells were found in urinalysis. After discontinuing PTU and starting immunosuppressive agent treatment, the fever, hematuria, and pulmonary hemorrhage subsided but the p-ANCA was still present several months later. ANCA-associated pulmonary-renal syndrome may be a complication of PTU therapy. The proportion of ANCA-positive case increases with the prolongation of PTU therapy. In contrast, there are rare reports of ANCA-associated vasculitis in the other thionamide i.e. carbimazole and methimazole. Therefore, carbimazole or methimazole may be the drug of choice when long-term treatment for hyperthyroidism is required.

Original languageEnglish
Pages (from-to)230-235
Number of pages6
JournalJournal of Internal Medicine of Taiwan
Volume16
Issue number5
Publication statusPublished - 2005
Externally publishedYes

Keywords

  • Antineutrophil cytoplasmic antibody
  • Microscopic polyangiitis
  • Propylthiouracil
  • Pulmonary-renal syndrome

ASJC Scopus subject areas

  • Internal Medicine

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