Abstract

Objective: This meta-analysis was performed to assess the efficacy of cryotherapy and nail solution (NS) use in preventing nail toxicity (NT) induced by taxane-based chemotherapy. Methods: PubMed, EMBASE, Cochrane Library and ClinicalTrials.gov registry databases were searched for relevant studies published up to December 2018. The primary outcome was taxane-induced NT. Secondary outcomes were skin toxicity (ST), time to toxicity and patient comfort. Results: We reviewed three randomised control trials and six prospective studies with 708 patients. For meta-analysis, taxane-induced NT grading was compared. NT and ST were significantly lower in the cryotherapy patients than in the controls (grade 1 NT: risk ratio [RR] = 0.51, 95% confidence interval [CI] = 0.30–0.89; grade 2–3 NT: RR = 0.36, 95% CI = 0.11–1.12; total NT: RR = 0.49; 95% CI = 0.30–0.79; ST: RR = 0.46, 95% CI = 0.33–0.64). The NS-treated patients exhibited significantly lower NT than the controls. Conclusions: Nail solution-treated or cryotherapy patients exhibited lower NT incidence and severity associated with taxane-based chemotherapy than the controls. For patients who can afford and comply with NS use or cryotherapy, these measures represent effective prophylactic management for taxane-induced NT and improve their quality of life and functional statuses. Further studies are needed to establish the routine usage protocols, long-term efficacy and safety for these interventions.

Original languageEnglish
Article numbere13118
JournalEuropean Journal of Cancer Care
DOIs
Publication statusPublished - 2019

Fingerprint

Nails
Meta-Analysis
Cryotherapy
Odds Ratio
Confidence Intervals
taxane
Skin
Drug Therapy
PubMed
Libraries
Registries
Quality of Life

Keywords

  • chemotherapy
  • cryotherapy
  • frozen gloves
  • nail solution
  • nail toxicity
  • onycholysis
  • taxane

ASJC Scopus subject areas

  • Oncology

Cite this

Prophylactic management for taxane-induced nail toxicity : A systematic review and meta-analysis. / Huang, Kai Ling; Lin, Kuan Yu; Huang, Tsai Wei; Loh, El Wui; Hua, Yi Ming; Su, Hui Chen; Tam, Ka Wai.

In: European Journal of Cancer Care, 2019.

Research output: Contribution to journalArticle

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title = "Prophylactic management for taxane-induced nail toxicity: A systematic review and meta-analysis",
abstract = "Objective: This meta-analysis was performed to assess the efficacy of cryotherapy and nail solution (NS) use in preventing nail toxicity (NT) induced by taxane-based chemotherapy. Methods: PubMed, EMBASE, Cochrane Library and ClinicalTrials.gov registry databases were searched for relevant studies published up to December 2018. The primary outcome was taxane-induced NT. Secondary outcomes were skin toxicity (ST), time to toxicity and patient comfort. Results: We reviewed three randomised control trials and six prospective studies with 708 patients. For meta-analysis, taxane-induced NT grading was compared. NT and ST were significantly lower in the cryotherapy patients than in the controls (grade 1 NT: risk ratio [RR] = 0.51, 95{\%} confidence interval [CI] = 0.30–0.89; grade 2–3 NT: RR = 0.36, 95{\%} CI = 0.11–1.12; total NT: RR = 0.49; 95{\%} CI = 0.30–0.79; ST: RR = 0.46, 95{\%} CI = 0.33–0.64). The NS-treated patients exhibited significantly lower NT than the controls. Conclusions: Nail solution-treated or cryotherapy patients exhibited lower NT incidence and severity associated with taxane-based chemotherapy than the controls. For patients who can afford and comply with NS use or cryotherapy, these measures represent effective prophylactic management for taxane-induced NT and improve their quality of life and functional statuses. Further studies are needed to establish the routine usage protocols, long-term efficacy and safety for these interventions.",
keywords = "chemotherapy, cryotherapy, frozen gloves, nail solution, nail toxicity, onycholysis, taxane",
author = "Huang, {Kai Ling} and Lin, {Kuan Yu} and Huang, {Tsai Wei} and Loh, {El Wui} and Hua, {Yi Ming} and Su, {Hui Chen} and Tam, {Ka Wai}",
year = "2019",
doi = "10.1111/ecc.13118",
language = "English",
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T1 - Prophylactic management for taxane-induced nail toxicity

T2 - A systematic review and meta-analysis

AU - Huang, Kai Ling

AU - Lin, Kuan Yu

AU - Huang, Tsai Wei

AU - Loh, El Wui

AU - Hua, Yi Ming

AU - Su, Hui Chen

AU - Tam, Ka Wai

PY - 2019

Y1 - 2019

N2 - Objective: This meta-analysis was performed to assess the efficacy of cryotherapy and nail solution (NS) use in preventing nail toxicity (NT) induced by taxane-based chemotherapy. Methods: PubMed, EMBASE, Cochrane Library and ClinicalTrials.gov registry databases were searched for relevant studies published up to December 2018. The primary outcome was taxane-induced NT. Secondary outcomes were skin toxicity (ST), time to toxicity and patient comfort. Results: We reviewed three randomised control trials and six prospective studies with 708 patients. For meta-analysis, taxane-induced NT grading was compared. NT and ST were significantly lower in the cryotherapy patients than in the controls (grade 1 NT: risk ratio [RR] = 0.51, 95% confidence interval [CI] = 0.30–0.89; grade 2–3 NT: RR = 0.36, 95% CI = 0.11–1.12; total NT: RR = 0.49; 95% CI = 0.30–0.79; ST: RR = 0.46, 95% CI = 0.33–0.64). The NS-treated patients exhibited significantly lower NT than the controls. Conclusions: Nail solution-treated or cryotherapy patients exhibited lower NT incidence and severity associated with taxane-based chemotherapy than the controls. For patients who can afford and comply with NS use or cryotherapy, these measures represent effective prophylactic management for taxane-induced NT and improve their quality of life and functional statuses. Further studies are needed to establish the routine usage protocols, long-term efficacy and safety for these interventions.

AB - Objective: This meta-analysis was performed to assess the efficacy of cryotherapy and nail solution (NS) use in preventing nail toxicity (NT) induced by taxane-based chemotherapy. Methods: PubMed, EMBASE, Cochrane Library and ClinicalTrials.gov registry databases were searched for relevant studies published up to December 2018. The primary outcome was taxane-induced NT. Secondary outcomes were skin toxicity (ST), time to toxicity and patient comfort. Results: We reviewed three randomised control trials and six prospective studies with 708 patients. For meta-analysis, taxane-induced NT grading was compared. NT and ST were significantly lower in the cryotherapy patients than in the controls (grade 1 NT: risk ratio [RR] = 0.51, 95% confidence interval [CI] = 0.30–0.89; grade 2–3 NT: RR = 0.36, 95% CI = 0.11–1.12; total NT: RR = 0.49; 95% CI = 0.30–0.79; ST: RR = 0.46, 95% CI = 0.33–0.64). The NS-treated patients exhibited significantly lower NT than the controls. Conclusions: Nail solution-treated or cryotherapy patients exhibited lower NT incidence and severity associated with taxane-based chemotherapy than the controls. For patients who can afford and comply with NS use or cryotherapy, these measures represent effective prophylactic management for taxane-induced NT and improve their quality of life and functional statuses. Further studies are needed to establish the routine usage protocols, long-term efficacy and safety for these interventions.

KW - chemotherapy

KW - cryotherapy

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KW - nail solution

KW - nail toxicity

KW - onycholysis

KW - taxane

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