Prophylactic anticonvulsants for prevention of immediate and early postcraniotomy seizures

Shih Tseng Lee, Tai Ngar Lui, Chen Nen Chang, Wan Chun Cheng, Dah Jium Wang, Robert F. Heimburger, Chii Guang Lin

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Phenytoin (15 mg/kg) was administered intravenously to 189 patients shortly before their intracranial, supratentorial surgery was completed. Intravenous phenytoin of 5-6 mg/kg/day in three divided doses was administered daily for the first 3 postoperative days. Therapeutic serum levels (10-20 μg/mL) were achieved in 113 (59.8%) patients. An equally constituted, randomized control group of 185 patients received a placebo under identical conditions. The group receiving phenytoin had only one immediate and two early postoperative seizures. The 185 controls had four immediate and nine early postoperative seizures. None of the follow-up computed tomography scans of the patients with seizures showed postoperative hematoma. One patient had a significant tension pneumocranium, a possible cause of postoperative seizures. To avoid a decrease in the serum anticonvulsant level due to intraoperative blood loss, it is suggested that for patients who need an urgent or emergent craniotomy, prophylatic anticonvulsant medication should be given at least 20 minutes before completion of wound closure.

Original languageEnglish
Pages (from-to)361-364
Number of pages4
JournalSurgical Neurology
Volume31
Issue number5
DOIs
Publication statusPublished - 1989
Externally publishedYes

Fingerprint

Anticonvulsants
Seizures
Phenytoin
Craniotomy
Serum
Hematoma
Tomography
Placebos
Control Groups
Wounds and Injuries

Keywords

  • Anticonvulsant medication
  • Craniotomy
  • Intracranial surgery
  • Phenytoin
  • Postoperative seizures

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Lee, S. T., Lui, T. N., Chang, C. N., Cheng, W. C., Wang, D. J., Heimburger, R. F., & Lin, C. G. (1989). Prophylactic anticonvulsants for prevention of immediate and early postcraniotomy seizures. Surgical Neurology, 31(5), 361-364. https://doi.org/10.1016/0090-3019(89)90067-0

Prophylactic anticonvulsants for prevention of immediate and early postcraniotomy seizures. / Lee, Shih Tseng; Lui, Tai Ngar; Chang, Chen Nen; Cheng, Wan Chun; Wang, Dah Jium; Heimburger, Robert F.; Lin, Chii Guang.

In: Surgical Neurology, Vol. 31, No. 5, 1989, p. 361-364.

Research output: Contribution to journalArticle

Lee, ST, Lui, TN, Chang, CN, Cheng, WC, Wang, DJ, Heimburger, RF & Lin, CG 1989, 'Prophylactic anticonvulsants for prevention of immediate and early postcraniotomy seizures', Surgical Neurology, vol. 31, no. 5, pp. 361-364. https://doi.org/10.1016/0090-3019(89)90067-0
Lee, Shih Tseng ; Lui, Tai Ngar ; Chang, Chen Nen ; Cheng, Wan Chun ; Wang, Dah Jium ; Heimburger, Robert F. ; Lin, Chii Guang. / Prophylactic anticonvulsants for prevention of immediate and early postcraniotomy seizures. In: Surgical Neurology. 1989 ; Vol. 31, No. 5. pp. 361-364.
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