Prophylactic and therapeutic effects of honey on radiochemotherapy-induced mucositis

a meta-analysis of randomized controlled trials

Tzu Ming Liu, Yu Wei Luo, Ka Wai Tam, Chia Chin Lin, Tsai Wei Huang

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

© 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Oral mucositis is a common side effect of radiochemotherapy and may adversely affect the patients’ quality of life (QoL). Honey application may reduce the mucositis grade in patients. Here, we conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the prophylactic and therapeutic effects of honey on radiochemotherapy-induced oral mucositis. Methods: Publications on RCTs were extracted from the PubMed, Embase, CINAHL, and Cochrane Library databases. The primary outcomes were mucositis grades and pain scores. Secondary outcomes were the recovery time and QoL. The study was registered with PROSPERO (number CRD42018108486). Results: Nineteen RCTs, involving 1276 patients, were reviewed. Honey considerably mitigated oral mucositis in both prophylactic and therapeutic phases. In the prophylactic phase, intolerable mucositis development was significantly prevented in the honey-treated group (RR = 0.18, 95% confidence interval [CI] = 0.09 to 0.41). Patients treated with honey showed significant decrease in pain scores in the first month of treatment (weighted mean difference [WMD] = − 3.25, 95% CI = − 4.41 to − 2.09) and at the end of the treatment (WMD = − 2.32, 95% CI = − 4.47 to − 0.18). Conclusion: Honey, which is relatively cheap and easily available, prevented mucositis and effectively mitigate mucositis in patients after radiochemotherapy. Moreover, it significantly reduced the mucositis grade and engendered a fast and painless healing process. Therefore, honey use during and after radiochemotherapy is recommended for mucositis prevention and treatment.
Original languageEnglish
Pages (from-to)2361-2370
Number of pages10
JournalSupportive Care in Cancer
Volume27
Issue number7
Early online dateMar 2019
DOIs
Publication statusPublished - Jul 2019

Fingerprint

Mucositis
Honey
Chemoradiotherapy
Therapeutic Uses
Meta-Analysis
Randomized Controlled Trials
Stomatitis
Confidence Intervals
Quality of Life
Pain
Therapeutics
PubMed
Libraries
Germany
Publications
Databases

Keywords

  • Chemotherapy
  • Honey
  • Meta-analysis
  • Mucositis
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology

Cite this

@article{548409d3b733488c8faf859103d2aa2c,
title = "Prophylactic and therapeutic effects of honey on radiochemotherapy-induced mucositis: a meta-analysis of randomized controlled trials",
abstract = "{\circledC} 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Oral mucositis is a common side effect of radiochemotherapy and may adversely affect the patients’ quality of life (QoL). Honey application may reduce the mucositis grade in patients. Here, we conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the prophylactic and therapeutic effects of honey on radiochemotherapy-induced oral mucositis. Methods: Publications on RCTs were extracted from the PubMed, Embase, CINAHL, and Cochrane Library databases. The primary outcomes were mucositis grades and pain scores. Secondary outcomes were the recovery time and QoL. The study was registered with PROSPERO (number CRD42018108486). Results: Nineteen RCTs, involving 1276 patients, were reviewed. Honey considerably mitigated oral mucositis in both prophylactic and therapeutic phases. In the prophylactic phase, intolerable mucositis development was significantly prevented in the honey-treated group (RR = 0.18, 95{\%} confidence interval [CI] = 0.09 to 0.41). Patients treated with honey showed significant decrease in pain scores in the first month of treatment (weighted mean difference [WMD] = − 3.25, 95{\%} CI = − 4.41 to − 2.09) and at the end of the treatment (WMD = − 2.32, 95{\%} CI = − 4.47 to − 0.18). Conclusion: Honey, which is relatively cheap and easily available, prevented mucositis and effectively mitigate mucositis in patients after radiochemotherapy. Moreover, it significantly reduced the mucositis grade and engendered a fast and painless healing process. Therefore, honey use during and after radiochemotherapy is recommended for mucositis prevention and treatment.",
keywords = "Chemotherapy, Honey, Meta-analysis, Mucositis, Radiotherapy",
author = "Liu, {Tzu Ming} and Luo, {Yu Wei} and Tam, {Ka Wai} and Lin, {Chia Chin} and Huang, {Tsai Wei}",
year = "2019",
month = "7",
doi = "10.1007/s00520-019-04722-3",
language = "English",
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pages = "2361--2370",
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TY - JOUR

T1 - Prophylactic and therapeutic effects of honey on radiochemotherapy-induced mucositis

T2 - a meta-analysis of randomized controlled trials

AU - Liu, Tzu Ming

AU - Luo, Yu Wei

AU - Tam, Ka Wai

AU - Lin, Chia Chin

AU - Huang, Tsai Wei

PY - 2019/7

Y1 - 2019/7

N2 - © 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Oral mucositis is a common side effect of radiochemotherapy and may adversely affect the patients’ quality of life (QoL). Honey application may reduce the mucositis grade in patients. Here, we conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the prophylactic and therapeutic effects of honey on radiochemotherapy-induced oral mucositis. Methods: Publications on RCTs were extracted from the PubMed, Embase, CINAHL, and Cochrane Library databases. The primary outcomes were mucositis grades and pain scores. Secondary outcomes were the recovery time and QoL. The study was registered with PROSPERO (number CRD42018108486). Results: Nineteen RCTs, involving 1276 patients, were reviewed. Honey considerably mitigated oral mucositis in both prophylactic and therapeutic phases. In the prophylactic phase, intolerable mucositis development was significantly prevented in the honey-treated group (RR = 0.18, 95% confidence interval [CI] = 0.09 to 0.41). Patients treated with honey showed significant decrease in pain scores in the first month of treatment (weighted mean difference [WMD] = − 3.25, 95% CI = − 4.41 to − 2.09) and at the end of the treatment (WMD = − 2.32, 95% CI = − 4.47 to − 0.18). Conclusion: Honey, which is relatively cheap and easily available, prevented mucositis and effectively mitigate mucositis in patients after radiochemotherapy. Moreover, it significantly reduced the mucositis grade and engendered a fast and painless healing process. Therefore, honey use during and after radiochemotherapy is recommended for mucositis prevention and treatment.

AB - © 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Oral mucositis is a common side effect of radiochemotherapy and may adversely affect the patients’ quality of life (QoL). Honey application may reduce the mucositis grade in patients. Here, we conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the prophylactic and therapeutic effects of honey on radiochemotherapy-induced oral mucositis. Methods: Publications on RCTs were extracted from the PubMed, Embase, CINAHL, and Cochrane Library databases. The primary outcomes were mucositis grades and pain scores. Secondary outcomes were the recovery time and QoL. The study was registered with PROSPERO (number CRD42018108486). Results: Nineteen RCTs, involving 1276 patients, were reviewed. Honey considerably mitigated oral mucositis in both prophylactic and therapeutic phases. In the prophylactic phase, intolerable mucositis development was significantly prevented in the honey-treated group (RR = 0.18, 95% confidence interval [CI] = 0.09 to 0.41). Patients treated with honey showed significant decrease in pain scores in the first month of treatment (weighted mean difference [WMD] = − 3.25, 95% CI = − 4.41 to − 2.09) and at the end of the treatment (WMD = − 2.32, 95% CI = − 4.47 to − 0.18). Conclusion: Honey, which is relatively cheap and easily available, prevented mucositis and effectively mitigate mucositis in patients after radiochemotherapy. Moreover, it significantly reduced the mucositis grade and engendered a fast and painless healing process. Therefore, honey use during and after radiochemotherapy is recommended for mucositis prevention and treatment.

KW - Chemotherapy

KW - Honey

KW - Meta-analysis

KW - Mucositis

KW - Radiotherapy

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