Properties of astaxanthin/Ca2+ complex formation in the deceleration of Cis/trans isomerization

Chien Sheng Chen, Shih Hsiung Wu, Ying Ying Wu, Jim Min Fang, Tzu Hua Wu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Deceleration of the regioselective cis/trans isomerization of all-trans-astaxanthin (ASTX) in the presence of Ca2+ was shown by HPLC analysis. The NMR and ITC analyses provided evidence for complexation of ASTX with Ca2+ in 1:2 stoichiometry via chelation at both carbonyl and hydroxyl groups. The rotation across torsion ω6 (C5-C6-C7-C8) upon complexation is consistent with the NOE between 7-H and 5-CH3. This study supports the inhibitory effect of ASTX on calcium-induced turbidity of lens crystallins.

Original languageEnglish
Pages (from-to)2985-2988
Number of pages4
JournalOrganic Letters
Volume9
Issue number16
DOIs
Publication statusPublished - Aug 2 2007

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ASJC Scopus subject areas

  • Molecular Medicine

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