Properties of astaxanthin/Ca2+ complex formation in the deceleration of Cis/trans isomerization

Chien Sheng Chen, Shih Hsiung Wu, Ying Ying Wu, Jim Min Fang, Tzu Hua Wu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Deceleration of the regioselective cis/trans isomerization of all-trans-astaxanthin (ASTX) in the presence of Ca2+ was shown by HPLC analysis. The NMR and ITC analyses provided evidence for complexation of ASTX with Ca2+ in 1:2 stoichiometry via chelation at both carbonyl and hydroxyl groups. The rotation across torsion ω6 (C5-C6-C7-C8) upon complexation is consistent with the NOE between 7-H and 5-CH3. This study supports the inhibitory effect of ASTX on calcium-induced turbidity of lens crystallins.

Original languageEnglish
Pages (from-to)2985-2988
Number of pages4
JournalOrganic Letters
Volume9
Issue number16
DOIs
Publication statusPublished - Aug 2 2007

Fingerprint

chelation
Deceleration
turbidity
deceleration
Isomerization
isomerization
torsion
calcium
stoichiometry
lenses
Complexation
nuclear magnetic resonance
Crystallins
Turbidity
Chelation
Stoichiometry
Hydroxyl Radical
Torsional stress
Lenses
High Pressure Liquid Chromatography

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Properties of astaxanthin/Ca2+ complex formation in the deceleration of Cis/trans isomerization. / Chen, Chien Sheng; Wu, Shih Hsiung; Wu, Ying Ying; Fang, Jim Min; Wu, Tzu Hua.

In: Organic Letters, Vol. 9, No. 16, 02.08.2007, p. 2985-2988.

Research output: Contribution to journalArticle

Chen, Chien Sheng ; Wu, Shih Hsiung ; Wu, Ying Ying ; Fang, Jim Min ; Wu, Tzu Hua. / Properties of astaxanthin/Ca2+ complex formation in the deceleration of Cis/trans isomerization. In: Organic Letters. 2007 ; Vol. 9, No. 16. pp. 2985-2988.
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