Prolonged injection time and light smoking decrease the incidence of fentanyl-induced cough

Jui A. Lin, Chun Chang Yeh, Meei Shyuan Lee, Ching Tang Wu, Shinn Long Lin, Chih Shung Wong

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

We designed this study to evaluate the effect of injection time and smoking on fentanyl-induced cough. Four-hundred-fifty ASA class I-II patients, aged 18-80 yr and weighing 40-90 kg, scheduled for elective surgery were included. All patients received fentanyl (100 μg for patients weighing 40-69 kg and 150 μg for patients weighing 70-90 kg for clinical convenience) via the proximal port of a peripheral IV line on the forearm. Patients were randomly assigned to 3 groups of 150 patients each. Patients in Group I received fentanyl injection over 2 s, whereas for patients in Groups II and III the fentanyl was injected at a constant rate over 15 s and 30 s, respectively. We recorded the number of coughs of each patient during and 30 s after fentanyl injection. The incidence of cough was 18% in group I, 8% in Group II, and 1.3% in Group III, significantly less (P <0.05) with a longer injection time. Current smokers had a less frequent incidence of cough than nonsmokers; however, this effect was only significant in light smokers (

Original languageEnglish
Pages (from-to)670-674
Number of pages5
JournalAnesthesia and Analgesia
Volume101
Issue number3
DOIs
Publication statusPublished - Sep 2005
Externally publishedYes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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