Prolonged cytogenetic and hematologic remission of blastic transformation in chronic granulogytic leukemia

George P. Canellos, Jacqueline Whang‐Peng, Lowell Schnipper, Clarence H. Brown

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A patient with blastic transformation of Ph′ positive chronic granulocytic leukemia is presented in whom a long drug‐induced remission was achieved. Serial cytogenetic studies were performed through the course of the illness which demonstrated a major hypodiploid cell line associated with the blastic leukemia. Remission was accompanied by a return to the diploid chromosomal constitution which characterized the chronic phase of the disease. An unusual responsiveness to the effects of vincristine and prednisone was demonstrated by the case, which resulted in a survival of 28 months following the onset of blastic transformation. Eventual refractoriness to therapy was associated with a new cell line suggesting a pattern of clonal evolution. The Ph′ chromosome was present throughout the course of the disease.

Original languageEnglish
Pages (from-to)288-293
Number of pages6
JournalCancer
Volume30
Issue number1
DOIs
Publication statusPublished - Jan 1 1972
Externally publishedYes

Fingerprint

Cytogenetics
Leukemia
Clonal Evolution
Cell Line
Constitution and Bylaws
Vincristine
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Prednisone
Diploidy
Chronic Disease
Chromosomes
Survival
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

Cite this

Prolonged cytogenetic and hematologic remission of blastic transformation in chronic granulogytic leukemia. / Canellos, George P.; Whang‐Peng, Jacqueline; Schnipper, Lowell; Brown, Clarence H.

In: Cancer, Vol. 30, No. 1, 01.01.1972, p. 288-293.

Research output: Contribution to journalArticle

Canellos, George P. ; Whang‐Peng, Jacqueline ; Schnipper, Lowell ; Brown, Clarence H. / Prolonged cytogenetic and hematologic remission of blastic transformation in chronic granulogytic leukemia. In: Cancer. 1972 ; Vol. 30, No. 1. pp. 288-293.
@article{82aace787cf3417da2bfce294291ff86,
title = "Prolonged cytogenetic and hematologic remission of blastic transformation in chronic granulogytic leukemia",
abstract = "A patient with blastic transformation of Ph′ positive chronic granulocytic leukemia is presented in whom a long drug‐induced remission was achieved. Serial cytogenetic studies were performed through the course of the illness which demonstrated a major hypodiploid cell line associated with the blastic leukemia. Remission was accompanied by a return to the diploid chromosomal constitution which characterized the chronic phase of the disease. An unusual responsiveness to the effects of vincristine and prednisone was demonstrated by the case, which resulted in a survival of 28 months following the onset of blastic transformation. Eventual refractoriness to therapy was associated with a new cell line suggesting a pattern of clonal evolution. The Ph′ chromosome was present throughout the course of the disease.",
author = "Canellos, {George P.} and Jacqueline Whang‐Peng and Lowell Schnipper and Brown, {Clarence H.}",
year = "1972",
month = "1",
day = "1",
doi = "10.1002/1097-0142(197207)30:1<288::AID-CNCR2820300140>3.0.CO;2-A",
language = "English",
volume = "30",
pages = "288--293",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - Prolonged cytogenetic and hematologic remission of blastic transformation in chronic granulogytic leukemia

AU - Canellos, George P.

AU - Whang‐Peng, Jacqueline

AU - Schnipper, Lowell

AU - Brown, Clarence H.

PY - 1972/1/1

Y1 - 1972/1/1

N2 - A patient with blastic transformation of Ph′ positive chronic granulocytic leukemia is presented in whom a long drug‐induced remission was achieved. Serial cytogenetic studies were performed through the course of the illness which demonstrated a major hypodiploid cell line associated with the blastic leukemia. Remission was accompanied by a return to the diploid chromosomal constitution which characterized the chronic phase of the disease. An unusual responsiveness to the effects of vincristine and prednisone was demonstrated by the case, which resulted in a survival of 28 months following the onset of blastic transformation. Eventual refractoriness to therapy was associated with a new cell line suggesting a pattern of clonal evolution. The Ph′ chromosome was present throughout the course of the disease.

AB - A patient with blastic transformation of Ph′ positive chronic granulocytic leukemia is presented in whom a long drug‐induced remission was achieved. Serial cytogenetic studies were performed through the course of the illness which demonstrated a major hypodiploid cell line associated with the blastic leukemia. Remission was accompanied by a return to the diploid chromosomal constitution which characterized the chronic phase of the disease. An unusual responsiveness to the effects of vincristine and prednisone was demonstrated by the case, which resulted in a survival of 28 months following the onset of blastic transformation. Eventual refractoriness to therapy was associated with a new cell line suggesting a pattern of clonal evolution. The Ph′ chromosome was present throughout the course of the disease.

UR - http://www.scopus.com/inward/record.url?scp=0015368473&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015368473&partnerID=8YFLogxK

U2 - 10.1002/1097-0142(197207)30:1<288::AID-CNCR2820300140>3.0.CO;2-A

DO - 10.1002/1097-0142(197207)30:1<288::AID-CNCR2820300140>3.0.CO;2-A

M3 - Article

VL - 30

SP - 288

EP - 293

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 1

ER -