Proliferating cell nuclear antigen (PCNA) immunolabeling as a prognostic factor in invasive ductal carcinoma of the breast in Taiwan

Jan Show Chu, Chiun Sheng Huang, King Jen Chang

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

To evaluate the prognostic significance of proliferating cell nuclear antigen (PCNA) in breast cancer, an immunohistochemical assay was performed in 150 patients with invasive ductal carcinomas. The PCNA labeling index (PCNA-LI) was classified into two subgroups at a cut-off point of 45% that gave the best prognostic estimates for PCNA in survival analyses. Seventy-eight tumors had a low PCNA-LI of ≤45% and 72 tumors had a high PCNA-LI of >45%. A high PCNA-LI correlated significantly with p53 overexpression (P

Original languageEnglish
Pages (from-to)145-152
Number of pages8
JournalCancer Letters
Volume131
Issue number2
DOIs
Publication statusPublished - Sep 25 1998
Externally publishedYes

Keywords

  • Breast cancer
  • Immunohistochemistry
  • p53
  • PCNA

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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