Projecting partial least square and principle component regression across microarray studies

Chi Cheng Hunag, Shin Hsin Tu, Heng Hui Lien, Ching Shui Huang, Eric Y. Chuang, Liang Chuan Lai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The study was to compare principle component (PC) versus partial least square (PLS) regression, the former unsupervised and the latter supervised gene component analysis, for highly complicated and correlated microarray gene expression profile. Projection of derived classifiers into independent samples for clinical phenotype prediction was evaluated as well. Previous studies had suggested that PLS might be superior to PC regression in the task of tumor classification since the covariance between predictive and respondent variables was maximized for latent factor extraction. We applied both algorithms for classifier construction and validated their prediction performance on independent microarray experiments. The statistical strategy could reduce high-dimensionality of microarray features and avoid the collinearity problem inherited in gene expression profiles. Proposed predictive model could discriminate breast cancers with positive and negative estrogen receptor status successfully and was feasible for both Taiwanese and Chinese females, both with the same Han Chinese ethnic origin.

Original languageEnglish
Title of host publication2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2010
Pages506-511
Number of pages6
DOIs
Publication statusPublished - 2010
Event2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2010 - HongKong, China
Duration: Dec 18 2010Dec 21 2010

Other

Other2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2010
CountryChina
CityHongKong
Period12/18/1012/21/10

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ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics

Cite this

Hunag, C. C., Tu, S. H., Lien, H. H., Huang, C. S., Chuang, E. Y., & Lai, L. C. (2010). Projecting partial least square and principle component regression across microarray studies. In 2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2010 (pp. 506-511). [5703853] https://doi.org/10.1109/BIBMW.2010.5703853