Abstract

End-stage renal disease (ESRD) has a major impact on health and affects more than 600,000 people in the USA. The current mainstay treatments include dialysis and kidney transplantation (KT), and patients who have received KT have a higher quality of life and a lower mortality risk than those on chronic dialysis. Therefore, KT is considered the more preferred treatment modality for patients with ESRD. However, even though KT results in a higher long-term survival rate, the use of immunosuppressants is associated with various complications, including opportunistic infections and malignancies, which may lead to a higher risk of death in the first year after transplantation. Progressive multifocal leukoencephalopathy (PML) is a rare complication following KT, with an incidence of 0.027% in KT recipients. We present a case of PML following immunosuppressant therapy in a patient who received KT.

Original languageEnglish
JournalJournal of NeuroVirology
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Progressive Multifocal Leukoencephalopathy
Kidney Transplantation
Transplants
Kidney
Immunosuppressive Agents
Chronic Kidney Failure
Dialysis
Opportunistic Infections
Therapeutics
Survival Rate
Transplantation
Quality of Life
Mortality
Incidence
Health

Keywords

  • Immunosuppressant agents
  • JC virus
  • Kidney transplantation
  • Progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

Cite this

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title = "Progressive multifocal leukoencephalopathy in a renal transplant patient",
abstract = "End-stage renal disease (ESRD) has a major impact on health and affects more than 600,000 people in the USA. The current mainstay treatments include dialysis and kidney transplantation (KT), and patients who have received KT have a higher quality of life and a lower mortality risk than those on chronic dialysis. Therefore, KT is considered the more preferred treatment modality for patients with ESRD. However, even though KT results in a higher long-term survival rate, the use of immunosuppressants is associated with various complications, including opportunistic infections and malignancies, which may lead to a higher risk of death in the first year after transplantation. Progressive multifocal leukoencephalopathy (PML) is a rare complication following KT, with an incidence of 0.027{\%} in KT recipients. We present a case of PML following immunosuppressant therapy in a patient who received KT.",
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author = "Lin, {Tsu Chen} and Wu, {Mei Yi} and Luh, {Hui Tzung} and Lin, {Shiou Fu} and Lin, {Chien Min} and Tseng, {Ying Chi} and Liu, {Yung Ching} and Wu, {Mai Szu}",
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AU - Lin, Tsu Chen

AU - Wu, Mei Yi

AU - Luh, Hui Tzung

AU - Lin, Shiou Fu

AU - Lin, Chien Min

AU - Tseng, Ying Chi

AU - Liu, Yung Ching

AU - Wu, Mai Szu

PY - 2019/1/1

Y1 - 2019/1/1

N2 - End-stage renal disease (ESRD) has a major impact on health and affects more than 600,000 people in the USA. The current mainstay treatments include dialysis and kidney transplantation (KT), and patients who have received KT have a higher quality of life and a lower mortality risk than those on chronic dialysis. Therefore, KT is considered the more preferred treatment modality for patients with ESRD. However, even though KT results in a higher long-term survival rate, the use of immunosuppressants is associated with various complications, including opportunistic infections and malignancies, which may lead to a higher risk of death in the first year after transplantation. Progressive multifocal leukoencephalopathy (PML) is a rare complication following KT, with an incidence of 0.027% in KT recipients. We present a case of PML following immunosuppressant therapy in a patient who received KT.

AB - End-stage renal disease (ESRD) has a major impact on health and affects more than 600,000 people in the USA. The current mainstay treatments include dialysis and kidney transplantation (KT), and patients who have received KT have a higher quality of life and a lower mortality risk than those on chronic dialysis. Therefore, KT is considered the more preferred treatment modality for patients with ESRD. However, even though KT results in a higher long-term survival rate, the use of immunosuppressants is associated with various complications, including opportunistic infections and malignancies, which may lead to a higher risk of death in the first year after transplantation. Progressive multifocal leukoencephalopathy (PML) is a rare complication following KT, with an incidence of 0.027% in KT recipients. We present a case of PML following immunosuppressant therapy in a patient who received KT.

KW - Immunosuppressant agents

KW - JC virus

KW - Kidney transplantation

KW - Progressive multifocal leukoencephalopathy

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