Progressive exercise preconditioning protects against circulatory shock during experimental heatstroke

Ching Hsia Hung, Nen Chung Chang, Bor Chih Cheng, Mao Tsun Lin

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Heat shock protein (HSP) 72 expression protects against arterial hypotension in rat heatstroke. HSP72 can also be induced in multiple organs, including hearts from rats with endurance exercise. We validated the hypothesis that progressive exercise preconditioning may confer cardiovascular protection during heatstroke by inducing the overexpression of HSP72 in multiple organs. To deal with the matter, we assessed the effects of heatstroke on mean arterial pressure, heart rate, cardiac output, stroke volume, total peripheral vascular resistance, colonic temperature, blood gases, and serum or tissue levels of tumor necrosis factor-α (TNF-α) in urethane-anesthetized rats pretreated without or with progressive exercise training for 1, 2, or 3 weeks. In addition, HSP72 expression in multiple organs was determined in different groups of animals. Heatstroke was induced by exposing the rats to a high blanket temperature (43°C); the moment at which mean arterial pressure decreased from the peak value was taken as the time of heatstroke onset. Previous exercise training for 3 weeks, but not 1 or 2 weeks, conferred significant protection against hyperthermia, arterial hypotension, decreased cardiac output, decreased stroke volume, decreased peripheral vascular resistance, and increased levels of serum or tissue TNF-α during heatstroke and correlated with overexpression of HSP72 in multiple organs, including heart, liver, and adrenal gland. However, 10 days after 3 weeks of progressive exercise training, when HSP72 expression in multiple organs returned to basal values, the beneficial effects exerted by 3 weeks of exercise training were no longer observed. These results strongly suggest that HSP72 preconditioning with progressive exercise training protects against hyperthermia, circulatory shock, and TNF-α overproduction during heatstroke.

Original languageEnglish
Pages (from-to)426-433
Number of pages8
JournalShock
Volume23
Issue number5
DOIs
Publication statusPublished - May 2005

Fingerprint

Heat Stroke
Shock
Vascular Resistance
Exercise
Tumor Necrosis Factor-alpha
Cardiac Output
Stroke Volume
Hypotension
Arterial Pressure
Fever
HSP72 Heat-Shock Proteins
Temperature
Urethane
Adrenal Glands
Serum
Heart Rate
Gases
Liver

Keywords

  • Arterial hypotension
  • Exercise
  • Heat shock protein
  • Heat stress
  • Hyperthermia
  • Stroke volume

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Physiology

Cite this

Progressive exercise preconditioning protects against circulatory shock during experimental heatstroke. / Hung, Ching Hsia; Chang, Nen Chung; Cheng, Bor Chih; Lin, Mao Tsun.

In: Shock, Vol. 23, No. 5, 05.2005, p. 426-433.

Research output: Contribution to journalArticle

Hung, Ching Hsia ; Chang, Nen Chung ; Cheng, Bor Chih ; Lin, Mao Tsun. / Progressive exercise preconditioning protects against circulatory shock during experimental heatstroke. In: Shock. 2005 ; Vol. 23, No. 5. pp. 426-433.
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