Progression rates of colorectal cancer by Dukes' stage in a high-risk group: Analysis of selective colorectal cancer screening

Jau Min Wong, Ming Fang Yen, Mei Shu Lai, Stephen W. Duffy, Robert A. Smith, Tony Hsiu Hsi Chen

Research output: Contribution to journalArticle

14 Citations (Scopus)


PURPOSE: The progression rates of colorectal cancer by Dukes' stage in a high-risk group were estimated and applied to evaluate the efficacy of different screening regimens. PATIENTS AND METHODS: Of 6303 high-risk subjects invited to a colorectal cancer screening project with colonoscopy, 39 screen-detected cases and 16 postscreening cases were diagnosed with information available on Dukes' stage. A five-state Markov process was applied to estimate parameters pertaining to the disease natural history of colorectal cancer by Dukes' stage. RESULTS: The estimates of the mean sojourn time in years were 3.10 for preclinical Dukes' A and B and 1.92 for preclinical Dukes' stages C and D. The predicted reductions of Dukes' stages C and D achieved by annual, biennial, 3-yearly, and 6-yearly screening regimens against the control group were 60%, 49%, 40%, and 25%, respectively. These, in turn, yield the corresponding predicted mortality reductions of 39%, 33%, 28%, and 18%. CONCLUSIONS: These findings suggest that to achieve a 30% mortality reduction, as observed in annual fecal occult blood testing, a prudent interscreening interval with colonoscopy for this high-risk group should not be longer than 3 years.

Original languageEnglish
Pages (from-to)160-169
Number of pages10
JournalCancer Journal
Issue number3
Publication statusPublished - May 2004
Externally publishedYes



  • Colonoscopy
  • Colorectal cancer screening
  • Dukes' stage
  • High-risk group
  • Markov process

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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