Progression of chronic kidney disease and the risk of tuberculosis

an observational cohort study

P J-Y Cho, C-Y Wu, J Johnston, M-Y Wu, C-C Shu, H-H Lin

Research output: Contribution to journalArticle

Abstract

<sec id="st1"> <title>BACKGROUND</title> Little is known about tuberculosis (TB) risk in the earlier stages of chronic kidney disease (CKD). </sec> <sec id="st2"> <title>OBJECTIVE</title> To investigate the relationship between CKD at all stages and the risk of incident TB. </sec> <sec id="st3"> <title>METHODS</title> We conducted a cohort study using 100 058 participants of a community-based health screening programme in northern Taiwan, 2005-2008. Renal function was ascertained at baseline using serum creatinine level and the urine dipstick test. The occurrence of active TB was ascertained using the National Tuberculosis Registry. Cox proportional hazards regression was used to estimate the association between CKD and TB. </sec> <sec id="st4"> <title>RESULTS</title> During a median follow-up of 7.5 years, TB incidence was 472. In the Cox regression analyses, individuals with Stage 1-4 CKD had a 25% increase in TB hazard than those without disease (adjusted hazard ratio [aHR] 1.25, 95%CI 1.02-1.54). A positive correlation between CKD stage and TB was observed (P = 0.02 for trend). TB risk increased by 5.1% with every 10 ml/min/1.73 m² decrease in the estimated glomerular filtration rate (aHR 1.05, 95%CI 0.99-1.12). </sec> <sec id="st5"> <title>CONCLUSIONS</title> Our results suggested an increased risk of TB in early-stage CKD. TB prevention efforts should consider individuals with earlier stages of CKD. </sec>.

Original languageEnglish
Pages (from-to)555-562
Number of pages8
JournalInternational Journal of Tuberculosis and Lung Disease
Volume23
Issue number5
DOIs
Publication statusPublished - May 1 2019

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Chronic Renal Insufficiency
Observational Studies
Tuberculosis
Cohort Studies
Glomerular Filtration Rate
Taiwan
Registries
Creatinine
Regression Analysis
Urine
Kidney
Incidence
Health

Cite this

Progression of chronic kidney disease and the risk of tuberculosis : an observational cohort study. / Cho, P J-Y; Wu, C-Y; Johnston, J; Wu, M-Y; Shu, C-C; Lin, H-H.

In: International Journal of Tuberculosis and Lung Disease, Vol. 23, No. 5, 01.05.2019, p. 555-562.

Research output: Contribution to journalArticle

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title = "Progression of chronic kidney disease and the risk of tuberculosis: an observational cohort study",
abstract = "BACKGROUND Little is known about tuberculosis (TB) risk in the earlier stages of chronic kidney disease (CKD). OBJECTIVE To investigate the relationship between CKD at all stages and the risk of incident TB. METHODS We conducted a cohort study using 100 058 participants of a community-based health screening programme in northern Taiwan, 2005-2008. Renal function was ascertained at baseline using serum creatinine level and the urine dipstick test. The occurrence of active TB was ascertained using the National Tuberculosis Registry. Cox proportional hazards regression was used to estimate the association between CKD and TB. RESULTS During a median follow-up of 7.5 years, TB incidence was 472. In the Cox regression analyses, individuals with Stage 1-4 CKD had a 25{\%} increase in TB hazard than those without disease (adjusted hazard ratio [aHR] 1.25, 95{\%}CI 1.02-1.54). A positive correlation between CKD stage and TB was observed (P = 0.02 for trend). TB risk increased by 5.1{\%} with every 10 ml/min/1.73 m² decrease in the estimated glomerular filtration rate (aHR 1.05, 95{\%}CI 0.99-1.12). CONCLUSIONS Our results suggested an increased risk of TB in early-stage CKD. TB prevention efforts should consider individuals with earlier stages of CKD. .",
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T1 - Progression of chronic kidney disease and the risk of tuberculosis

T2 - an observational cohort study

AU - Cho, P J-Y

AU - Wu, C-Y

AU - Johnston, J

AU - Wu, M-Y

AU - Shu, C-C

AU - Lin, H-H

PY - 2019/5/1

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N2 - BACKGROUND Little is known about tuberculosis (TB) risk in the earlier stages of chronic kidney disease (CKD). OBJECTIVE To investigate the relationship between CKD at all stages and the risk of incident TB. METHODS We conducted a cohort study using 100 058 participants of a community-based health screening programme in northern Taiwan, 2005-2008. Renal function was ascertained at baseline using serum creatinine level and the urine dipstick test. The occurrence of active TB was ascertained using the National Tuberculosis Registry. Cox proportional hazards regression was used to estimate the association between CKD and TB. RESULTS During a median follow-up of 7.5 years, TB incidence was 472. In the Cox regression analyses, individuals with Stage 1-4 CKD had a 25% increase in TB hazard than those without disease (adjusted hazard ratio [aHR] 1.25, 95%CI 1.02-1.54). A positive correlation between CKD stage and TB was observed (P = 0.02 for trend). TB risk increased by 5.1% with every 10 ml/min/1.73 m² decrease in the estimated glomerular filtration rate (aHR 1.05, 95%CI 0.99-1.12). CONCLUSIONS Our results suggested an increased risk of TB in early-stage CKD. TB prevention efforts should consider individuals with earlier stages of CKD. .

AB - BACKGROUND Little is known about tuberculosis (TB) risk in the earlier stages of chronic kidney disease (CKD). OBJECTIVE To investigate the relationship between CKD at all stages and the risk of incident TB. METHODS We conducted a cohort study using 100 058 participants of a community-based health screening programme in northern Taiwan, 2005-2008. Renal function was ascertained at baseline using serum creatinine level and the urine dipstick test. The occurrence of active TB was ascertained using the National Tuberculosis Registry. Cox proportional hazards regression was used to estimate the association between CKD and TB. RESULTS During a median follow-up of 7.5 years, TB incidence was 472. In the Cox regression analyses, individuals with Stage 1-4 CKD had a 25% increase in TB hazard than those without disease (adjusted hazard ratio [aHR] 1.25, 95%CI 1.02-1.54). A positive correlation between CKD stage and TB was observed (P = 0.02 for trend). TB risk increased by 5.1% with every 10 ml/min/1.73 m² decrease in the estimated glomerular filtration rate (aHR 1.05, 95%CI 0.99-1.12). CONCLUSIONS Our results suggested an increased risk of TB in early-stage CKD. TB prevention efforts should consider individuals with earlier stages of CKD. .

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