Progress in delivery of siRNA-based therapeutics employing nano-vehicles for treatment of prostate cancer

Milad Ashrafizadeh, Kiavash Hushmandi, Ebrahim Rahmani Moghadam, Vahideh Zarrin, Sharareh Hosseinzadeh Kashani, Saied Bokaie, Masoud Najafi, Shima Tavakol, Reza Mohammadinejad, Noushin Nabavi, Chia Ling Hsieh, Atefeh Zarepour, Ehsan Nazarzadeh Zare, Ali Zarrabi, Pooyan Makvandi

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Prostate cancer (PCa) accounts for a high number of deaths in males with no available curative treatments. Patients with PCa are commonly diagnosed in advanced stages due to the lack of symptoms in the early stages. Recently, the research focus was directed toward gene editing in cancer therapy. Small interfering RNA (siRNA) intervention is considered as a powerful tool for gene silencing (knockdown), enabling the suppression of oncogene factors in cancer. This strategy is applied to the treatment of various cancers including PCa. The siRNA can inhibit proliferation and invasion of PCa cells and is able to promote the anti-tumor activity of chemotherapeutic agents. However, the o_-target e_ects of siRNA therapy remarkably reduce its e_cacy in PCa therapy. To date, various carriers were designed to improve the delivery of siRNA and, among them, nanoparticles are of importance. Nanoparticles enable the targeted delivery of siRNAs and enhance their potential in the downregulation of target genes of interest. Additionally, nanoparticles can provide a platform for the co-delivery of siRNAs and anti-tumor drugs, resulting in decreased growth and migration of PCa cells. The e_cacy, specificity, and delivery of siRNAs are comprehensively discussed in this review to direct further studies toward using siRNAs and their nanoscale-delivery systems in PCa therapy and perhaps other cancer types.

Original languageEnglish
Article number91
Pages (from-to)1-40
Number of pages40
JournalBioengineering
Volume7
Issue number3
DOIs
Publication statusPublished - Sep 2020

Keywords

  • Cancer therapy
  • Delivery systems
  • Gene therapy
  • Nanoparticle
  • Prostate cancer
  • Small interfering RNA (siRNA)

ASJC Scopus subject areas

  • Bioengineering

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